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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:irinotecan pharmacokinetics pathway
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Accession:PW:0001225 term browser browse the term
Definition:The pathway of processing - absorption, distribution, metabolism or elimination - of irinotecan, a drug used in the treatment of several types of cancer. Genetic variations can result in changes in the availability of the drug.
Synonyms:related_synonym: SMP:00600


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irinotecan pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO SMPDB SMP:00600 NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) ISO SMPDB SMP:00600 NCBI chr 5:14,972,589...15,164,594
Ensembl chr 5:14,972,646...15,164,567
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 ISO SMPDB SMP:00600 NCBI chr 9:92,826,423...92,902,389
Ensembl chr 9:92,841,818...92,902,265
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (JR blood group) ISO SMPDB SMP:00600 NCBI chr 7:36,458,110...36,599,753 JBrowse link
G BCHE butyrylcholinesterase ISO SMPDB SMP:00600 NCBI chr15:23,708,121...23,778,027
Ensembl chr15:23,708,155...23,778,286
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 ISO SMPDB SMP:00600 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507
JBrowse link
G DNAJB11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00600 NCBI chr15:2,841,377...2,858,192
Ensembl chr15:2,841,255...2,858,202
JBrowse link
G ERP29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00600 NCBI chr11:107,244,359...107,255,293
Ensembl chr11:107,244,335...107,256,499
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00600 NCBI chr11:99,119,268...99,139,988
Ensembl chr11:99,119,224...99,139,722
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00600 NCBI chr12:12,920,705...12,925,888
Ensembl chr12:12,920,710...12,927,431
JBrowse link
G HYOU1 hypoxia up-regulated 1 ISO SMPDB SMP:00600 NCBI chr 1:110,418,497...110,431,636
Ensembl chr 1:110,417,942...110,431,590
JBrowse link
G LOC103233018 liver carboxylesterase 1 ISO SMPDB SMP:00600 NCBI chr 5:41,710,500...41,745,483 JBrowse link
G LOC103246766 cytochrome P450 3A8 ISO SMPDB SMP:00600 NCBI chr28:13,297,566...13,330,023 JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 ISO SMPDB SMP:00600 NCBI chr 5:229,523...233,298
Ensembl chr 5:229,607...233,200
JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 ISO SMPDB SMP:00600 NCBI chr21:117,574,932...117,601,896
Ensembl chr21:117,574,427...117,601,960
JBrowse link
G PDIA6 protein disulfide isomerase family A member 6 ISO SMPDB SMP:00600 NCBI chr14:96,801,327...96,828,325
Ensembl chr14:96,801,349...96,828,716
JBrowse link
G PPIB peptidylprolyl isomerase B ISO SMPDB SMP:00600 NCBI chr26:19,380,496...19,399,596 JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 ISO SMPDB SMP:00600 NCBI chr19:4,465,795...4,467,882
Ensembl chr19:4,465,797...4,467,761
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 ISO SMPDB SMP:00600 NCBI chr11:20,992,353...21,091,761
Ensembl chr11:21,001,655...21,093,278
JBrowse link
G TOP1 DNA topoisomerase I ISO SMPDB SMP:00600 NCBI chr 2:22,655,085...22,751,082
Ensembl chr 2:22,651,995...22,751,102
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4028
    drug pathway 383
      antineoplastic and immunomodulatory drug pathway 145
        antineoplastic drug pathway 144
          irinotecan drug pathway 20
            irinotecan pharmacokinetics pathway 20
paths to the root