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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:altered kinase mediated signaling pathway
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Accession:PW:0001198 term browser browse the term


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altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055
Ensembl chr10:47,766,680...47,775,055
JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425, PMID:21277552, PMID:20951313, PMID:18098337 RGD:2293882, RGD:5133243, RGD:5133242, RGD:2298531 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Kras KRAS proto-oncogene, GTPase TAS
ISO
RGD PMID:16112461, PMID:18772397, PMID:19506583, PMID:20951313, PMID:19078924 RGD:2306732, RGD:5490966, RGD:5490965, RGD:5133242, RGD:4143515 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO RGD PMID:20951313, PMID:21277552 RGD:5133242, RGD:5133243 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
altered Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 ISS RGD PMID:12032773 RGD:1357939 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jak3 Janus kinase 3 ISS RGD PMID:12032773 RGD:1357939 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:18955974, PMID:21277552 RGD:2313763, RGD:5133243 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:18955974, PMID:15166380, PMID:19506583 RGD:2313763, RGD:2313408, RGD:5490965 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO RGD PMID:18955974 RGD:2313763 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:18955974, PMID:19078924, PMID:20951313, PMID:21277552 RGD:2313763, RGD:4143515, RGD:5133242, RGD:5133243 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:18955974, PMID:19506583, PMID:20951313, PMID:19078924, PMID:18008377 RGD:2313763, RGD:5490965, RGD:5133242, RGD:4143515, RGD:2326139 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6102
    signaling pathway 2645
      kinase mediated signaling pathway 598
        altered kinase mediated signaling pathway 13
          altered serine/threonine-specific kinase mediated signaling pathway + 11
          altered tyrosine-specific protein kinase mediated signaling pathway + 2
paths to the root