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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:sorafenib drug pathway
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Accession:PW:0001107 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics pathway of sorafenib, a multikinase inhibitor used in the treatment of cancer, in particular for advanced renal cell carcinoma. The drug binds to the intracytoplasmic domain of tyrosine kinase receptors blocking the downstream signaling cascade. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.


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sorafenib pharmacokinetics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 ISO SMPDB SMP:00648 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 ISO SMPDB SMP:00648
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 ISO SMPDB SMP:00648 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Dnajb11 DnaJ heat shock protein family (Hsp40) member B11 ISO SMPDB SMP:00648 NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 ISO SMPDB SMP:00648 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 ISO SMPDB SMP:00648 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO SMPDB SMP:00648 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hyou1 hypoxia up-regulated 1 ISO SMPDB SMP:00648 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186 		JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 ISO SMPDB SMP:00648 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931 		JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 ISO SMPDB SMP:00648 NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107 		JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 ISO SMPDB SMP:00648 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613 		JBrowse link
G Ppib peptidylprolyl isomerase B ISO SMPDB SMP:00648 NCBI chr 8:66,603,877...66,609,734
Ensembl chr 8:66,603,861...66,630,428 		JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 ISO SMPDB SMP:00648 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 ISO SMPDB SMP:00648 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 ISO SMPDB SMP:00648 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        antineoplastic drug pathway 154
          sorafenib drug pathway 15
            sorafenib pharmacodynamics pathway 0
            sorafenib pharmacokinetics pathway 15
paths to the root