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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:systemic lupus erythematosus pathway
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Accession:PW:0001023 term browser browse the term
Definition:Systemic lupus erythematosus (SLE) is an autoimmune condition that can affect many parts of the body and which, although treatable, does not have a cure. Activation of complement and deregulations of immune regulatory and signaling pathways contribute in ways that are incompletely understood.
Synonyms:exact_synonym: SLE pathway
 related_synonym: KEGG:05322


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systemic lupus erythematosus pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn1 actinin, alpha 1 IEA KEGG rno:05322 NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:98,998,556...99,093,251 		JBrowse link
G Actn2 actinin alpha 2 IEA KEGG rno:05322 NCBI chr17:62,835,055...62,902,331
Ensembl chr17:58,142,625...58,210,622 		JBrowse link
G Actn3 actinin alpha 3 IEA KEGG rno:05322 NCBI chr 1:211,588,473...211,604,401
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Actn4 actinin alpha 4 IEA KEGG rno:05322 NCBI chr 1:93,310,294...93,379,369
Ensembl chr 1:84,182,788...84,251,847 		JBrowse link
G C1qa complement C1q A chain IEA KEGG rno:05322 NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534 		JBrowse link
G C1qb complement C1q B chain IEA KEGG rno:05322 NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:149,118,846...149,124,407 		JBrowse link
G C1qc complement C1q C chain IEA KEGG rno:05322 NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017 		JBrowse link
G C1r complement C1r IEA KEGG rno:05322 NCBI chr 4:159,099,013...159,109,770
Ensembl chr 4:157,412,692...157,423,484 		JBrowse link
G C1s complement C1s IEA KEGG rno:05322 NCBI chr 4:159,116,549...159,128,736
Ensembl chr 4:157,430,117...157,442,303 		JBrowse link
G C2 complement C2 IEA KEGG rno:05322 NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505 		JBrowse link
G C3 complement C3 IEA KEGG rno:05322 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G C4b complement C4B IEA KEGG rno:05322 NCBI chr20:4,201,979...4,216,292
Ensembl chr20:4,197,366...4,211,681 		JBrowse link
G C5 complement C5 IEA KEGG rno:05322 NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G C6 complement C6 IEA KEGG rno:05322 NCBI chr 2:55,573,596...55,648,857
Ensembl chr 2:53,851,985...53,921,275 		JBrowse link
G C7 complement C7 IEA KEGG rno:05322 NCBI chr 2:55,815,687...55,892,605
Ensembl chr 2:54,088,116...54,158,535 		JBrowse link
G C8a complement C8 alpha chain IEA KEGG rno:05322 NCBI chr 5:124,812,131...124,866,631
Ensembl chr 5:119,583,174...119,637,754 		JBrowse link
G C8b complement C8 beta chain IEA KEGG rno:05322 NCBI chr 5:124,763,974...124,801,522
Ensembl chr 5:119,535,146...119,572,565 		JBrowse link
G C8g complement C8 gamma chain IEA KEGG rno:05322 NCBI chr 3:28,718,648...28,720,232
Ensembl chr 3:8,305,920...8,323,495 		JBrowse link
G C9 complement C9 IEA KEGG rno:05322 NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338 		JBrowse link
G Cd28 Cd28 molecule IEA KEGG rno:05322 NCBI chr 9:69,660,316...69,689,192
Ensembl chr 9:62,166,192...62,194,685 		JBrowse link
G Cd40 CD40 molecule IEA KEGG rno:05322 NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand IEA KEGG rno:05322 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd80 Cd80 molecule IEA KEGG rno:05322 NCBI chr11:75,760,073...75,798,978
Ensembl chr11:62,254,624...62,292,030 		JBrowse link
G Cd86 CD86 molecule IEA KEGG rno:05322 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Ctsg cathepsin G IEA KEGG rno:05322 NCBI chr15:33,901,230...33,907,596
Ensembl chr15:29,931,003...29,937,353 		JBrowse link
G Elane elastase, neutrophil expressed IEA KEGG rno:05322 NCBI chr 7:10,467,877...10,469,725
Ensembl chr 7:9,817,252...9,819,100 		JBrowse link
G Fcgr1a Fc gamma receptor 1A IEA KEGG rno:05322 NCBI chr 2:186,539,941...186,548,941
Ensembl chr 2:183,851,077...183,859,994 		JBrowse link
G Fcgr2a Fc gamma receptor 2A IEA KEGG rno:05322 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fcgr2b Fc gamma receptor 2B IEA KEGG rno:05322 NCBI chr13:85,725,897...85,740,517
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fcgr3a Fc gamma receptor 3A IEA KEGG rno:05322 NCBI chr13:85,782,636...85,792,656
Ensembl chr13:83,249,872...83,259,921 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A IEA KEGG rno:05322 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B IEA KEGG rno:05322 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G H2ab3 H2A.B variant histone 3 IEA KEGG rno:05322 NCBI chr  X:86,566,994...86,567,568
Ensembl chr  X:82,362,633...82,362,983 		JBrowse link
G H2ac1 H2A clustered histone 1 IEA KEGG rno:05322 NCBI chr17:41,599,195...41,599,672
Ensembl chr17:41,135,489...41,172,022 		JBrowse link
G H2ac18 H2A clustered histone 18 IEA KEGG rno:05322 NCBI chr 2:186,497,271...186,497,865 JBrowse link
G H2ac20 H2A clustered histone 20 IEA KEGG rno:05322 NCBI chr 2:186,468,748...186,469,226 JBrowse link
G H2ac21 H2A clustered histone 21 IEA KEGG rno:05322 NCBI chr 2:186,468,224...186,468,657 JBrowse link
G H2ac25 H2A clustered histone 25 IEA KEGG rno:05322 NCBI chr10:44,233,283...44,234,835
Ensembl chr10:43,733,668...43,744,874 		JBrowse link
G H2ac4 H2A clustered histone 4 IEA KEGG rno:05322 NCBI chr17:47,495,624...47,496,127
Ensembl chr17:42,799,652...42,800,381 		JBrowse link
G H2aj H2A.J histone IEA KEGG rno:05322 NCBI chr 4:171,406,922...171,407,406
Ensembl chr 4:169,675,752...169,677,006 		JBrowse link
G H2ax H2A.X variant histone IEA KEGG rno:05322 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239 		JBrowse link
G H2az1 H2A.Z variant histone 1 IEA KEGG rno:05322 NCBI chr 2:229,026,464...229,031,411
Ensembl chr 2:226,355,708...226,358,485 		JBrowse link
G H2az2l3 H2A.Z histone variant 2 like 3 IEA KEGG rno:05322 NCBI chr18:82,884,679...82,885,311
Ensembl chr18:80,609,861...80,610,556 		JBrowse link
G H2bc1 H2B clustered histone 1 IEA KEGG rno:05322 NCBI chr17:41,599,912...41,600,381
Ensembl chr17:41,171,903...41,176,782
Ensembl chr17:41,171,903...41,176,782 		JBrowse link
G H2bc12 H2B clustered histone 12 IEA KEGG rno:05322 NCBI chr17:47,181,477...47,181,940 JBrowse link
G H2bc8 H2B clustered histone 8 IEA KEGG rno:05322 NCBI chr17:47,404,405...47,405,155 JBrowse link
G H2bc9 H2B clustered histone 9 IEA KEGG rno:05322 NCBI chr17:47,166,372...47,174,369 JBrowse link
G H2bu1 H2B.U histone 1 IEA KEGG rno:05322 NCBI chr10:44,232,318...44,233,065
Ensembl chr10:43,732,864...43,736,277 		JBrowse link
G H3-7l H3.7 histone like IEA KEGG rno:05322 NCBI chr 7:102,145,916...102,146,683 JBrowse link
G H3f3al3 H3.3 histone A like 3 IEA KEGG rno:05322 NCBI chr 9:49,989,995...49,990,754
Ensembl chr 9:42,494,353...42,494,763 		JBrowse link
G H3f3b H3.3 histone B IEA KEGG rno:05322 NCBI chr10:101,755,404...101,764,616
Ensembl chr10:101,256,480...101,258,709
Ensembl chr13:101,256,480...101,258,709 		JBrowse link
G H4c14 H4 clustered histone 14 IEA KEGG rno:05322 NCBI chr 2:186,520,468...186,520,863
Ensembl chr 2:183,825,994...183,832,048 		JBrowse link
G Hist1h2ac histone cluster 1 H2A family member C IEA KEGG rno:05322 NCBI chr17:47,174,615...47,175,085
Ensembl chr17:42,478,860...42,479,252
Ensembl chr17:42,478,860...42,479,252 		JBrowse link
G Hist1h2af histone cluster 1 H2A family member F IEA KEGG rno:05322 NCBI chr17:41,807,261...41,807,653
Ensembl chr17:41,379,404...41,379,796 		JBrowse link
G Hist1h2ah histone cluster 1 H2A family member H IEA KEGG rno:05322 NCBI chr17:41,812,378...41,812,875 JBrowse link
G Hist1h2ai histone cluster 1, H2ai IEA KEGG rno:05322 NCBI chr17:47,414,053...47,414,540
Ensembl chr17:41,534,691...41,539,869
Ensembl chr17:41,534,691...41,539,869 		JBrowse link
G Hist1h2an histone cluster 1, H2an IEA KEGG rno:05322 NCBI chr17:41,961,533...41,963,297
Ensembl chr17:41,534,691...41,539,869 		JBrowse link
G Hist1h2ao histone cluster 1, H2ao IEA KEGG rno:05322 NCBI chr17:47,400,488...47,400,878
Ensembl chr17:42,698,025...42,698,958
Ensembl chr17:42,698,025...42,698,958
Ensembl chr17:42,698,025...42,698,958
Ensembl chr17:42,698,025...42,698,958
Ensembl chr17:42,698,025...42,698,958
Ensembl chr17:42,698,025...42,698,958
Ensembl chr17:42,698,025...42,698,958
Ensembl chr 2:42,698,025...42,698,958
Ensembl chr 4:42,698,025...42,698,958 		JBrowse link
G Hist1h2bc histone cluster 1, H2bc IEA KEGG rno:05322 NCBI chr17:47,388,085...47,392,349
Ensembl chr17:42,694,723...42,696,642 		JBrowse link
G Hist1h2bg histone cluster 1, H2bg IEA KEGG rno:05322 NCBI chr17:41,999,269...42,000,237
Ensembl chr17:41,571,210...41,571,896 		JBrowse link
G Hist1h4b histone cluster 1 H4 family member B IEA KEGG rno:05322 NCBI chr17:47,176,246...47,180,690
Ensembl chr17:42,480,313...42,485,370 		JBrowse link
G Hist1h4m histone cluster 1, H4m IEA KEGG rno:05322 NCBI chr17:47,393,764...47,394,168
Ensembl chr17:42,698,025...42,698,958 		JBrowse link
G Hist2h2be histone cluster 2 H2B family member E IEA KEGG rno:05322 NCBI chr 2:186,469,452...186,471,899 JBrowse link
G Hist2h3c2 histone cluster 2 H3 family member C2 IEA KEGG rno:05322 NCBI chr 2:186,526,162...186,526,587
Ensembl chr 2:183,837,303...183,837,752 		JBrowse link
G Hist3h2ba histone cluster 3, H2ba IEA KEGG rno:05322 NCBI chr10:44,225,421...44,226,050
Ensembl chr10:43,724,930...43,727,107 		JBrowse link
G Ifng interferon gamma IEA KEGG rno:05322 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 IEA KEGG rno:05322 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Macroh2a1 macroH2A.1 histone IEA KEGG rno:05322 NCBI chr17:8,484,340...8,547,268
Ensembl chr17:8,479,372...8,542,072 		JBrowse link
G Macroh2a2 macroH2A.2 histone IEA KEGG rno:05322 NCBI chr20:30,220,975...30,270,652
Ensembl chr20:29,678,222...29,727,891 		JBrowse link
G Mcpt8l2 mast cell protease 8-like 2 IEA KEGG rno:05322 NCBI chr15:33,718,389...33,731,960 JBrowse link
G Mcpt8l3 mast cell protease 8-like 3 IEA KEGG rno:05322 NCBI chr15:33,673,264...33,676,288 JBrowse link
G Ro60 Ro60, Y RNA binding protein IEA KEGG rno:05322 NCBI chr13:58,049,838...58,070,828
Ensembl chr13:55,499,534...55,520,504 		JBrowse link
G RT1-Ba RT1 class II, locus Ba IEA KEGG rno:05322 NCBI chr20:4,577,057...4,581,650
Ensembl chr20:4,575,134...4,579,744 		JBrowse link
G RT1-Bb RT1 class II, locus Bb IEA KEGG rno:05322 NCBI chr20:4,598,475...4,604,118
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
G RT1-Da RT1 class II, locus Da IEA KEGG rno:05322 NCBI chr20:4,515,393...4,520,387
Ensembl chr20:4,512,911...4,518,455 		JBrowse link
G RT1-Db1 RT1 class II, locus Db1 IEA KEGG rno:05322 NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258 		JBrowse link
G RT1-DMa RT1 class II, locus DMa IEA KEGG rno:05322 NCBI chr20:4,708,932...4,712,335
Ensembl chr20:4,707,028...4,710,432 		JBrowse link
G RT1-DMb RT1 class II, locus DMb IEA KEGG rno:05322 NCBI chr20:4,695,009...4,702,560
Ensembl chr20:4,693,103...4,700,340 		JBrowse link
G RT1-DOa RT1 class II, locus DOa IEA KEGG rno:05322 NCBI chr20:4,755,287...4,758,491
Ensembl chr20:4,753,598...4,756,577 		JBrowse link
G RT1-DOb RT1 class II, locus DOb IEA KEGG rno:05322 NCBI chr20:4,621,336...4,627,537
Ensembl chr20:4,619,816...4,625,667 		JBrowse link
G RT1-Ha RT1 class II, locus Ha IEA KEGG rno:05322 NCBI chr20:4,762,425...4,772,439
Ensembl chr20:4,760,118...4,770,244 		JBrowse link
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 IEA KEGG rno:05322 NCBI chr 3:137,824,870...137,832,479
Ensembl chr 3:117,370,100...117,379,339 		JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide IEA KEGG rno:05322 NCBI chr18:1,969,351...1,980,207
Ensembl chr18:1,696,852...1,708,256 		JBrowse link
G Ssb small RNA binding exonuclease protection factor La IEA KEGG rno:05322 NCBI chr 3:75,024,385...75,034,016
Ensembl chr 3:54,616,619...54,626,203 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:05322 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Trim21 tripartite motif-containing 21 IEA KEGG rno:05322 NCBI chr 1:166,376,829...166,399,441
Ensembl chr 1:156,964,913...156,987,440 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      immune system disease pathway 293
        systemic lupus erythematosus pathway 86
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