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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:methotrexate drug pathway
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Accession:PW:0000930 term browser browse the term
Definition:The pharmacokinetics and pharmacodynamics of methotrexate (MTX), a polyglutamatable antifolate used in the treatment of cancers and autoimmune diseases. The impact of MTX on cancer and rheumatoid arthritis is thought to arise through distinct mechanisms and pharmacodynamics pathways. Genetic variations can result in changes in drug availability and can cause differences in the response of the organism to the drug.
Synonyms:exact_synonym: MTX drug pathway


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methotrexate pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 ISO SMPDB SMP:00432 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465 		JBrowse link
G Dhfr dihydrofolate reductase ISO SMPDB SMP:00432 NCBI chr 2:25,320,895...25,346,004
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G Fpgs folylpolyglutamate synthase ISO SMPDB SMP:00432 NCBI chr 3:15,972,800...15,993,592
Ensembl chr 3:15,972,800...15,993,563 		JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase ISO SMPDB SMP:00432 NCBI chr20:12,055,203...12,068,717
Ensembl chr20:12,055,208...12,068,735 		JBrowse link
G Ggh gamma-glutamyl hydrolase ISO SMPDB SMP:00432 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787 		JBrowse link
G Mtfmt mitochondrial methionyl-tRNA formyltransferase ISO SMPDB SMP:00432 NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO SMPDB SMP:00432 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO SMPDB SMP:00432 NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase ISO SMPDB SMP:00432 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO SMPDB SMP:00432 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mthfs methenyltetrahydrofolate synthetase ISO SMPDB SMP:00432 NCBI chr 8:89,729,498...89,801,998
Ensembl chr 8:89,729,508...89,799,089 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 ISO SMPDB SMP:00432 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    drug pathway 397
      antineoplastic and immunomodulatory drug pathway 156
        immunosuppressant drug pathway 72
          methotrexate drug pathway 12
            methotrexate pharmacodynamics pathway 12
            methotrexate pharmacokinetics pathway 0
paths to the root