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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:de novo purine biosynthetic pathway
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Accession:PW:0000867 term browser browse the term
Definition:De novo purine biosynthesis requires ten enzymatic reactions to produce inosine monophosphate (IMP). Both adenine and guanine are then derived from IMP via several reactions. Purines are synthesized as nucleosides, i.e., as bases attached to ribose. Purines can also be created synthetically.
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de novo purine biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adsl adenylosuccinate lyase ISO RGD PMID:20005278 RGD:5135488 NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760 		JBrowse link
G Adss1 adenylosuccinate synthase 1 ISO RGD PMID:10218106 RGD:5143930 NCBI chr 6:131,679,795...131,702,012
Ensembl chr 6:131,679,701...131,701,998 		JBrowse link
G Adss2 adenylosuccinate synthase 2 ISO RGD PMID:10218106 RGD:5143930 NCBI chr13:89,769,240...89,799,577
Ensembl chr13:89,769,244...89,799,604 		JBrowse link
G Ak1 adenylate kinase 1 TAS RGD PMID:16167529 RGD:5490520 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041 		JBrowse link
G Ak2 adenylate kinase 2 TAS RGD PMID:16167529 RGD:5490520 NCBI chr 5:141,308,650...141,364,633
Ensembl chr 5:141,346,063...141,364,632 		JBrowse link
G Ak3 adenylate kinase 3 TAS RGD PMID:16167529 RGD:5490520 NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625 		JBrowse link
G Ak4 adenylate kinase 4 TAS RGD PMID:16167529 RGD:5490520 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618 		JBrowse link
G Ak5 adenylate kinase 5 ISO RGD PMID:16167529 RGD:5490520 NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA
ISO 		RGD PMID:9332377 PMID:20005278 RGD:70804, RGD:5135488 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase ISO RGD PMID:12450384 RGD:1547842 NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125 		JBrowse link
G Gmps guanine monophosphate synthase ISO RGD PMID:20005278 RGD:5135488 NCBI chr 2:148,441,369...148,491,908
Ensembl chr 2:148,435,643...148,485,875 		JBrowse link
G Impdh1 inosine monophosphate dehydrogenase 1 TAS RGD PMID:18295529 RGD:5144133 NCBI chr 4:57,801,842...57,817,434
Ensembl chr 4:57,801,831...57,819,076 		JBrowse link
G Impdh2 inosine monophosphate dehydrogenase 2 TAS RGD PMID:18295529 RGD:5144133 NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359 		JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase TAS RGD PMID:7742366 RGD:633692 NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635 		JBrowse link
G Ppat phosphoribosyl pyrophosphate amidotransferase ISO RGD PMID:20005278 RGD:5135488 NCBI chr14:31,215,741...31,250,144
Ensembl chr14:31,216,165...31,250,144 		JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 ISO RGD PMID:20005278 RGD:5135488 NCBI chr  X:104,132,139...104,154,191
Ensembl chr  X:104,132,141...104,154,187 		JBrowse link
G Prps1l1 phosphoribosyl pyrophosphate synthetase 1-like 1 ISO RGD PMID:20005278 RGD:5135488 NCBI chr 6:51,684,960...51,686,650
Ensembl chr 6:51,684,948...51,687,291 		JBrowse link
G Prps2 phosphoribosyl pyrophosphate synthetase 2 ISO RGD PMID:20005278 RGD:5135488 NCBI chr  X:26,975,915...27,013,184
Ensembl chr  X:26,976,061...27,013,181 		JBrowse link
G Taf9 TATA-box binding protein associated factor 9 ISO RGD PMID:16167529 RGD:5490520 NCBI chr 2:33,528,388...33,532,395
Ensembl chr 2:31,794,142...31,798,769 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1852
      nucleotide metabolic pathway 185
        purine metabolic pathway 157
          purine biosynthetic pathway 20
            de novo purine biosynthetic pathway 19
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