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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered transcription factor mediated signaling pathway
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Accession:PW:0000719 term browser browse the term
Definition:A transcription factor mediated signaling pathway that deviates from what its normal course should be. Deregulation of such pathways has been linked to cancer and various other diseases.

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altered androgen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor ISO RGD PMID:18008377, PMID:23759327 RGD:2326139, RGD:8693397 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701 		JBrowse link
altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845 		JBrowse link
altered p53 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ets1 ETS proto-oncogene 1, transcription factor ISO RGD PMID:22713868 RGD:8663430 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625 		JBrowse link
G Mdm2 MDM2 proto-oncogene ISO RGD PMID:19165225, PMID:23262034 RGD:2316186, RGD:8663434 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mdm4 MDM4 regulator of p53 ISO RGD PMID:23262034 RGD:8663434 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720 		JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO RGD PMID:23263379 RGD:8663431 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489 		JBrowse link
G Nfya nuclear transcription factor Y subunit alpha ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 9:14,551,752...14,577,002
Ensembl chr 9:14,551,758...14,576,967 		JBrowse link
G Nfyb nuclear transcription factor Y subunit beta ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 7:27,081,667...27,097,481
Ensembl chr 7:27,081,667...27,097,479 		JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 5:139,687,442...139,760,154
Ensembl chr 5:139,687,448...139,749,050 		JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:22713868 RGD:8663430 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603 		JBrowse link
G Tp53 tumor protein p53 ISO DNA:mutations:exon RGD PMID:19165225, PMID:23759327, PMID:22713868, PMID:23263379, PMID:18772397, PMID:20951313, PMID:19078924 RGD:2316186, RGD:8693397, RGD:8663430, RGD:8663431, RGD:5490966, RGD:5133242, RGD:4143515 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp63 tumor protein p63 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501 		JBrowse link
G Tp73 tumor protein p73 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:22713868 RGD:8663430 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6106
    signaling pathway 2647
      transcription factor mediated signaling pathway 460
        altered transcription factor mediated signaling pathway 17
          altered androgen signaling pathway 3
          altered basic helix-loop-helix signaling pathway + 0
          altered cortisol signaling pathway 0
          altered estrogen signaling pathway 0
          altered hypoxia inducible factor pathway 1
          altered nuclear factor kappa B signaling pathway 0
          altered p53 signaling pathway 13
          altered peroxisome proliferator-activated receptor signaling pathway 0
paths to the root