PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: altered transcription factor mediated signaling pathway
Accession: PW:0000719
browse the term
Definition: A transcription factor mediated signaling pathway that deviates from what its normal course should be. Deregulation of such pathways has been linked to cancer and various other diseases.
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Ar
androgen receptor
ISO
RGD
PMID:18008377 , PMID:23759327
RGD:2326139 , RGD:8693397
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
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Ncoa2
nuclear receptor coactivator 2
ISO
RGD
PMID:23759327
RGD:8693397
NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
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Ncor2
nuclear receptor co-repressor 2
ISO
RGD
PMID:23759327
RGD:8693397
NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
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Vhl
von Hippel-Lindau tumor suppressor
ISO
RGD
PMID:22035299
RGD:6907133
NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
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Ets1
ETS proto-oncogene 1, transcription factor
ISO
RGD
PMID:22713868
RGD:8663430
NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
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Mdm2
MDM2 proto-oncogene
ISO
RGD
PMID:19165225 , PMID:23262034
RGD:2316186 , RGD:8663434
NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
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Mdm4
MDM4 regulator of p53
ISO
RGD
PMID:23262034
RGD:8663434
NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
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Mre11
MRE11 homolog, double strand break repair nuclease
ISO
RGD
PMID:23263379
RGD:8663431
NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
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Nfya
nuclear transcription factor Y subunit alpha
ISO
RGD
PMID:23263379 , PMID:22713868
RGD:8663431 , RGD:8663430
NCBI chr 9:14,551,752...14,577,002
Ensembl chr 9:14,551,758...14,576,967
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Nfyb
nuclear transcription factor Y subunit beta
ISO
RGD
PMID:23263379 , PMID:22713868
RGD:8663431 , RGD:8663430
NCBI chr 7:27,081,667...27,097,481
Ensembl chr 7:27,081,667...27,097,479
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Nfyc
nuclear transcription factor Y subunit gamma
ISO
RGD
PMID:23263379 , PMID:22713868
RGD:8663431 , RGD:8663430
NCBI chr 5:139,687,442...139,760,154
Ensembl chr 5:139,687,448...139,749,050
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Pin1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
ISO
RGD
PMID:22713868
RGD:8663430
NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
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Srebf2
sterol regulatory element binding transcription factor 2
ISO
RGD
PMID:23263379 , PMID:22713868
RGD:8663431 , RGD:8663430
NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
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Tp53
tumor protein p53
ISO
DNA:mutations:exon
RGD
PMID:19165225 , PMID:23759327 , PMID:22713868 , PMID:23263379 , PMID:18772397 , PMID:20951313 , PMID:19078924
RGD:2316186 , RGD:8693397 , RGD:8663430 , RGD:8663431 , RGD:5490966 , RGD:5133242 , RGD:4143515
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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Tp63
tumor protein p63
ISO
RGD
PMID:23263379 , PMID:22713868
RGD:8663431 , RGD:8663430
NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
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Tp73
tumor protein p73
ISO
RGD
PMID:23263379 , PMID:22713868
RGD:8663431 , RGD:8663430
NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
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Vdr
vitamin D receptor
ISO
RGD
PMID:22713868
RGD:8663430
NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all