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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:small cell lung carcinoma pathway
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Accession:PW:0000704 term browser browse the term
Definition:Small cell lung cancer is an aggressive type of lung cancer. Several pathways appear to be deregulated and they include the intrinsic apoptotic pathway, PI3K-Akt signaling and changes in oncogene transcription factors such as Myc and p53.
Synonyms:exact_synonym: oat cell carcinoma of lung pathway;   small cell carcinoma of lung pathway;   small cell lung cancer pathway;   small cell neuroendocrine carcinoma of lung pathway
 related_synonym: KEGG:05222;   SCLC pathway;   small cell lung neoplasm pathway


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small cell lung carcinoma pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:05222 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:05222 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05222 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IEA KEGG rno:05222 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEA KEGG rno:05222 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 IEA KEGG rno:05222 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 IEA KEGG rno:05222 NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:13,253,706...13,271,911 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 IEA KEGG rno:05222 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05222 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05222 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ccne1 cyclin E1 IEA KEGG rno:05222 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:99,918,674...99,927,822 		JBrowse link
G Ccne2 cyclin E2 IEA KEGG rno:05222 NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:29,082,703...29,094,882 		JBrowse link
G Cdk2 cyclin dependent kinase 2 IEA KEGG rno:05222 NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 IEA KEGG rno:05222 NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 IEA KEGG rno:05222 NCBI chr 4:31,592,384...31,784,732
Ensembl chr 4:31,601,192...31,781,701 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B IEA KEGG rno:05222 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B IEA KEGG rno:05222 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:109,114,322...109,134,855 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:05222 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:252,908,749...252,944,273 		JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B IEA KEGG rno:05222 NCBI chr 2:177,130,751...177,135,333
Ensembl chr 2:177,130,777...177,135,365 		JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 IEA KEGG rno:05222 NCBI chr17:13,570,611...13,575,770
Ensembl chr17:13,722,361...13,727,519 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain IEA KEGG rno:05222 NCBI chr16:84,885,597...84,996,482
Ensembl chr16:84,885,597...84,996,482 		JBrowse link
G Col4a2 collagen type IV alpha 2 chain IEA KEGG rno:05222 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:84,749,672...84,885,520 		JBrowse link
G Col4a5 collagen type IV alpha 5 chain IEA KEGG rno:05222 NCBI chr  X:105,118,762...105,322,699
Ensembl chr  X:109,907,346...110,111,214 		JBrowse link
G Cycs cytochrome c, somatic IEA KEGG rno:05222 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyct cytochrome c, testis IEA KEGG rno:05222 NCBI chr 3:81,697,333...81,704,401
Ensembl chr 3:81,697,333...81,700,514 		JBrowse link
G E2f1 E2F transcription factor 1 IEA KEGG rno:05222 NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:163,524,739...163,535,563 		JBrowse link
G E2f3 E2F transcription factor 3 IEA KEGG rno:05222 NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,809,998...34,887,725 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase IEA KEGG rno:05222 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:16,747,338...17,872,621 		JBrowse link
G Fn1 fibronectin 1 IEA KEGG rno:05222 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:05222 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:05222 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:157,367,639...157,392,757 		JBrowse link
G Itga2 integrin subunit alpha 2 IEA KEGG rno:05222 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:48,253,412...48,354,509 		JBrowse link
G Itga2b integrin subunit alpha 2b IEA KEGG rno:05222 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,908,697...87,925,833 		JBrowse link
G Itga6 integrin subunit alpha 6 IEA KEGG rno:05222 NCBI chr 3:77,012,168...77,097,076
Ensembl chr 3:77,017,766...77,097,076 		JBrowse link
G Itgb1 integrin subunit beta 1 IEA KEGG rno:05222 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:73,602,126...73,650,269 		JBrowse link
G Lama1 laminin subunit alpha 1 IEA KEGG rno:05222 NCBI chr 9:115,139,548...115,263,620
Ensembl chr 9:115,139,548...115,264,251 		JBrowse link
G Lama2 laminin subunit alpha 2 IEA KEGG rno:05222 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:19,244,599...20,140,056 		JBrowse link
G Lama5 laminin subunit alpha 5 IEA KEGG rno:05222 NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:187,647,904...187,696,173 		JBrowse link
G Lamb2 laminin subunit beta 2 IEA KEGG rno:05222 NCBI chr 8:118,056,899...118,069,090
Ensembl chr 8:118,056,935...118,069,090 		JBrowse link
G Lamb3 laminin subunit beta 3 IEA KEGG rno:05222 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:107,322,526...107,404,081 		JBrowse link
G Lamc1 laminin subunit gamma 1 IEA KEGG rno:05222 NCBI chr13:67,924,872...68,051,986
Ensembl chr13:67,924,872...68,051,986 		JBrowse link
G Lamc2 laminin subunit gamma 2 IEA KEGG rno:05222 NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102 		JBrowse link
G Lamc3 laminin subunit gamma 3 IEA KEGG rno:05222 NCBI chr 3:15,165,220...15,226,697
Ensembl chr 3:35,562,713...35,624,460 		JBrowse link
G Max MYC associated factor X IEA KEGG rno:05222 NCBI chr 6:95,636,859...95,662,204
Ensembl chr 6:101,369,988...101,395,549 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:05222 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 IEA KEGG rno:05222 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nfkbia NFKB inhibitor alpha IEA KEGG rno:05222 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072 		JBrowse link
G Nos2 nitric oxide synthase 2 IEA KEGG rno:05222 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 IEA KEGG rno:05222 NCBI chr 8:63,338,150...63,451,670
Ensembl chr 8:72,233,566...72,334,315 		JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 IEA KEGG rno:05222 NCBI chr18:70,608,034...70,714,295
Ensembl chr18:72,882,890...73,006,662 		JBrowse link
G Pias3 protein inhibitor of activated STAT, 3 IEA KEGG rno:05222 NCBI chr 2:184,232,546...184,241,455
Ensembl chr 2:186,921,428...186,936,714 		JBrowse link
G Pias4 protein inhibitor of activated STAT, 4 IEA KEGG rno:05222 NCBI chr 7:8,546,312...8,559,838
Ensembl chr 7:9,196,896...9,210,527 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:05222 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05222 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05222 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05222 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05222 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05222 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05222 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Pten phosphatase and tensin homolog IEA KEGG rno:05222 NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:240,043,707...240,110,330 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 IEA KEGG rno:05222 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Ptk2 protein tyrosine kinase 2 IEA KEGG rno:05222 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091 		JBrowse link
G Rarb retinoic acid receptor, beta IEA KEGG rno:05222 NCBI chr15:10,837,252...11,482,037
Ensembl chr15:11,131,358...11,482,040 		JBrowse link
G Rb1 RB transcriptional corepressor 1 IEA KEGG rno:05222 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:54,780,858...54,911,857 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit IEA KEGG rno:05222 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rxra retinoid X receptor alpha IEA KEGG rno:05222 NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:31,388,223...31,474,417 		JBrowse link
G Rxrb retinoid X receptor beta IEA KEGG rno:05222 NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,818,709...4,825,359 		JBrowse link
G Rxrg retinoid X receptor gamma IEA KEGG rno:05222 NCBI chr13:82,276,330...82,318,097
Ensembl chr13:82,276,291...82,318,095 		JBrowse link
G Skp2 S-phase kinase associated protein 2 IEA KEGG rno:05222 NCBI chr 2:59,888,406...59,916,471
Ensembl chr 2:59,888,413...59,916,438 		JBrowse link
G Tp53 tumor protein p53 IEA KEGG rno:05222 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Traf2 Tnf receptor-associated factor 2 IEA KEGG rno:05222 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:28,740,098...28,764,691 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 IEA KEGG rno:05222 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:136,027,157...136,128,363 		JBrowse link
G Traf4 Tnf receptor associated factor 4 IEA KEGG rno:05222 NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,552,253...63,558,356 		JBrowse link
G Traf6 TNF receptor associated factor 6 IEA KEGG rno:05222 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:108,418,513...108,443,328 		JBrowse link
G Xiap X-linked inhibitor of apoptosis IEA KEGG rno:05222 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      cancer pathway 369
        thoracic cancer pathway 104
          respiratory tract cancer pathway 104
            lung cancer pathway 104
              small cell lung carcinoma pathway 75
paths to the root