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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:altered glycoconjugated protein signaling pathway
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Accession:PW:0000670 term browser browse the term
Definition:A glycoconjugated protein signaling pathway that deviates from what its normal course should be.



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altered Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 ISO RGD PMID:12548545 RGD:1334460 NCBI chr 4:56,859,640...56,863,807
Ensembl chr 4:56,859,663...56,863,789
JBrowse link
G NUMB NUMB endocytic adaptor protein ISO RGD PMID:15492044 RGD:1334451 NCBI chr 7:96,624,270...96,798,690
Ensembl chr 7:96,624,260...96,799,975
JBrowse link
altered Notch signaling pathway involving promoters term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 ISO RGD PMID:12548545 RGD:1334460 NCBI chr 4:56,859,640...56,863,807
Ensembl chr 4:56,859,663...56,863,789
JBrowse link
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUMB NUMB endocytic adaptor protein ISO RGD PMID:15492044 RGD:1334451 NCBI chr 7:96,624,270...96,798,690
Ensembl chr 7:96,624,260...96,799,975
JBrowse link
G PSEN2 presenilin 2 ISO C. elegans transgenics expressing wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chr10:14,532,556...14,561,862
Ensembl chr10:14,532,550...14,561,858
JBrowse link
altered Notch signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLL3 delta like canonical Notch ligand 3 ISO Mutations in the gene have been associated with Spondylocostal dysostosis RGD PMID:12141422 RGD:1304493 NCBI chr 6:48,135,738...48,155,373
Ensembl chr 6:48,147,730...48,155,373
JBrowse link
G JAG1 jagged canonical Notch ligand 1 ISO RGD PMID:15057910 RGD:1334443 NCBI chr17:19,591,248...19,629,659
Ensembl chr17:19,591,252...19,630,085
JBrowse link
G NOTCH1 notch receptor 1 ISO Mutations in the dimerization and/or PEST domain have been associated with human acute T-lymphoblastic leukemias RGD PMID:15472075 RGD:1334450
G NOTCH3 notch receptor 3 ISO Mutations are predominantly found in the EGF repeats and clustered within the first five RGD PMID:9388399 RGD:1334441 NCBI chr 2:62,364,507...62,402,348
Ensembl chr 2:62,364,501...62,402,344
JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAB1 DAB adaptor protein 1 ISO RGD PMID:12670697 PMID:12764038 PMID:16266828 RGD:1358468 RGD:2324967 RGD:727518 NCBI chr 6:154,156,595...155,374,403
Ensembl chr 6:154,936,439...155,374,403
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chr 1:77,584,675...77,810,605
Ensembl chr 1:77,585,439...77,810,581
JBrowse link
G ITGA3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr12:26,234,769...26,269,327
Ensembl chr12:26,234,753...26,271,561
JBrowse link
G ITGB1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795
JBrowse link
G LRP8 LDL receptor related protein 8 ISO RGD PMID:19846452 RGD:2324974 NCBI chr 6:158,905,464...158,984,743
Ensembl chr 6:158,905,460...158,982,873
JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chr12:48,567,329...48,735,836
Ensembl chr12:48,567,337...48,735,838
JBrowse link
G PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 9:44,513,114...44,534,312
Ensembl chr 9:44,513,456...44,536,432
JBrowse link
G PAFAH1B3 platelet activating factor acetylhydrolase 1b catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 6:49,635,625...49,638,172
Ensembl chr 6:49,619,240...49,638,172
JBrowse link
G RELN reelin ISO RGD PMID:12670697 PMID:12764038 RGD:1358468 RGD:727518 NCBI chr 9:103,460,855...103,963,728
Ensembl chr 9:103,460,857...103,963,965
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860
JBrowse link
G VLDLR very low density lipoprotein receptor ISO RGD PMID:12764038 RGD:1358468 NCBI chr 1:219,178,501...219,210,332
Ensembl chr 1:219,173,504...219,210,343
JBrowse link
altered Wnt signaling, canonical pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO RGD PMID:18432252 RGD:2293188 NCBI chr 2:116,913,354...116,985,303
Ensembl chr 2:116,812,582...117,034,912
JBrowse link
G AXIN1 axin 1 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 3:41,344,908...41,393,999
Ensembl chr 3:41,337,071...41,393,997
JBrowse link
G AXIN2 axin 2 ISO RGD PMID:18432252 RGD:2293188 NCBI chr12:12,311,293...12,343,207
Ensembl chr12:12,311,293...12,343,200
JBrowse link
G CTNNB1 catenin beta 1 ISO RGD PMID:18432252 PMID:19078924 RGD:2293188 RGD:4143515 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,137,173...25,208,311
JBrowse link
G LRP5 LDL receptor related protein 5 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 2:4,533,721...4,653,997
Ensembl chr 2:4,533,593...4,653,945
JBrowse link
G TCF7L2 transcription factor 7 like 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chr14:123,343,695...123,547,332
Ensembl chr14:123,343,694...123,546,417
JBrowse link
G WNT9A Wnt family member 9A ISO RGD PMID:18772397 RGD:5490966 NCBI chr 2:51,102,757...51,128,346
Ensembl chr 2:51,102,757...51,128,347
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4015
    signaling pathway 1912
      glycoconjugated protein signaling pathway 330
        altered glycoconjugated protein signaling pathway 25
          altered glycoprotein signaling pathway + 25
paths to the root