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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:altered glycoconjugated protein signaling pathway
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Accession:PW:0000670 term browser browse the term
Definition:A glycoconjugated protein signaling pathway that deviates from what its normal course should be.



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altered Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 ISO RGD PMID:12548545 RGD:1334460 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121
JBrowse link
G NUMB NUMB endocytic adaptor protein ISO RGD PMID:15492044 RGD:1334451 NCBI chr 8:46,620,444...46,781,564
Ensembl chr 8:46,607,556...46,782,175
JBrowse link
altered Notch signaling pathway involving promoters term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEY1 hes related family bHLH transcription factor with YRPW motif 1 ISO RGD PMID:12548545 RGD:1334460 NCBI chr29:27,185,191...27,188,121
Ensembl chr29:27,185,191...27,188,121
JBrowse link
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NUMB NUMB endocytic adaptor protein ISO RGD PMID:15492044 RGD:1334451 NCBI chr 8:46,620,444...46,781,564
Ensembl chr 8:46,607,556...46,782,175
JBrowse link
G PSEN2 presenilin 2 ISO C. elegans transgenics expressing wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chr 7:38,147,157...38,163,023
Ensembl chr 7:38,147,173...38,166,722
JBrowse link
altered Notch signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLL3 delta like canonical Notch ligand 3 ISO Mutations in the gene have been associated with Spondylocostal dysostosis RGD PMID:12141422 RGD:1304493 NCBI chr 1:113,737,662...113,745,936 JBrowse link
G JAG1 jagged canonical Notch ligand 1 ISO RGD PMID:15057910 RGD:1334443 NCBI chr24:11,656,926...11,693,146
Ensembl chr24:11,657,416...11,692,199
JBrowse link
G NOTCH1 notch receptor 1 ISO Mutations in the dimerization and/or PEST domain have been associated with human acute T-lymphoblastic leukemias RGD PMID:15472075 RGD:1334450 NCBI chr 9:48,975,972...49,018,985
Ensembl chr 9:48,974,757...49,017,277
JBrowse link
G NOTCH3 notch receptor 3 ISO Mutations are predominantly found in the EGF repeats and clustered within the first five RGD PMID:9388399 RGD:1334441 NCBI chr20:46,946,654...46,978,821
Ensembl chr20:46,937,485...46,978,219
JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAB1 DAB adaptor protein 1 ISO RGD PMID:12670697 PMID:12764038 PMID:16266828 RGD:1358468 RGD:2324967 RGD:727518 NCBI chr 5:51,397,837...52,505,513
Ensembl chr 5:52,231,141...52,502,336
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chr12:68,105,060...68,316,630
Ensembl chr12:68,075,184...68,316,541
JBrowse link
G ITGA3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr 9:26,065,792...26,095,649
Ensembl chr 9:26,062,393...26,094,422
JBrowse link
G ITGB1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chr 2:3,728,472...3,757,696
Ensembl chr 2:3,670,596...3,756,961
JBrowse link
G LRP8 LDL receptor related protein 8 ISO RGD PMID:19846452 RGD:2324974 NCBI chr 5:55,604,878...55,684,666
Ensembl chr 5:55,604,878...55,699,736
JBrowse link
G PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 9:46,648,057...46,731,259
Ensembl chr 9:46,648,052...46,771,400
JBrowse link
G PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040
G PAFAH1B3 platelet activating factor acetylhydrolase 1b catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:112,078,131...112,080,874
Ensembl chr 1:112,063,074...112,080,873
JBrowse link
G RELN reelin ISO RGD PMID:12670697 PMID:12764038 RGD:1358468 RGD:727518 NCBI chr18:16,275,822...16,773,875
Ensembl chr18:16,275,837...16,773,875
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077
JBrowse link
G VLDLR very low density lipoprotein receptor ISO RGD PMID:12764038 RGD:1358468 NCBI chr 1:91,242,010...91,277,030
Ensembl chr 1:91,241,509...91,272,495
JBrowse link
altered Wnt signaling, canonical pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO RGD PMID:18432252 RGD:2293188 NCBI chr 3:252,052...380,506
Ensembl chr 3:253,081...322,993
JBrowse link
G AXIN1 axin 1 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 6:40,155,797...40,218,330
Ensembl chr 6:40,158,244...40,218,343
JBrowse link
G AXIN2 axin 2 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 9:14,559,476...14,588,950
Ensembl chr 9:14,559,388...14,588,530
JBrowse link
G CTNNB1 catenin beta 1 ISO RGD PMID:18432252 PMID:19078924 RGD:2293188 RGD:4143515 NCBI chr23:10,559,722...10,572,933
Ensembl chr23:10,559,718...10,572,927
JBrowse link
G LRP5 LDL receptor related protein 5 ISO RGD PMID:18432252 RGD:2293188 NCBI chr18:49,439,494...49,555,375
Ensembl chr18:49,439,483...49,516,396
JBrowse link
G TCF7L2 transcription factor 7 like 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chr28:23,966,079...24,162,775
Ensembl chr28:23,966,073...24,163,737
JBrowse link
G WNT9A Wnt family member 9A ISO RGD PMID:18772397 RGD:5490966 NCBI chr14:946,843...959,289
Ensembl chr14:953,244...959,295
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4033
    signaling pathway 1926
      glycoconjugated protein signaling pathway 329
        altered glycoconjugated protein signaling pathway 25
          altered glycoprotein signaling pathway + 25
paths to the root