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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:colorectal cancer pathway
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Accession:PW:0000612 term browser browse the term
Definition:Colorectal cancer are malignant tumors of the colon and rectum. Both risk factors usually relating to life style such as physical exercise or use of tobacco and genetics contribute to the development of the condition. Mutations in the components of canonical Wnt and Smad-dependent TGF-beta signaling and of DNA mismatch repair pathways have been associated with the pathogenesis of colorectal cancer pathway.
Synonyms:related_synonym: KEGG:05210;   colorectal neoplasm pathway
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colorectal cancer pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 IEA KEGG rno:05210 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:05210 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05210 NCBI chr13:91,475,839...91,758,060
Ensembl chr13:91,475,839...91,748,020 		JBrowse link
G Apc APC regulator of WNT signaling pathway ISO
IEA 		KEGG
RGD		 PMID:18432252 rno:05210, RGD:2293188 NCBI chr18:26,138,382...26,196,021
Ensembl chr18:26,102,679...26,197,022 		JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 IEA KEGG rno:05210 NCBI chr 7:10,043,010...10,065,037
Ensembl chr 7:10,043,010...10,065,210 		JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 IEA KEGG rno:05210 NCBI chr16:2,125,234...2,173,457
Ensembl chr16:2,125,234...2,173,421 		JBrowse link
G Axin1 axin 1 ISO
IEA 		KEGG
RGD		 PMID:18432252 rno:05210, RGD:2293188 NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,667,958...15,720,092 		JBrowse link
G Axin2 axin 2 ISO
IEA 		KEGG
RGD		 PMID:18432252 rno:05210, RGD:2293188 NCBI chr10:94,393,379...94,426,579
Ensembl chr10:94,395,909...94,426,575 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:05210 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator IEA KEGG rno:05210 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEA KEGG rno:05210 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 IEA KEGG rno:05210 NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO
IEA 		KEGG
RGD		 PMID:18098337 rno:05210, RGD:2298531 NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:69,342,813...69,476,931 		JBrowse link
G Casp3 caspase 3 IEA KEGG rno:05210 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05210 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05210 NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810 		JBrowse link
G Ctnnb1 catenin beta 1 ISO
IEA 		KEGG
RGD		 PMID:18432252 rno:05210, RGD:2293188 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662 		JBrowse link
G Cycs cytochrome c, somatic IEA KEGG rno:05210 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Cyct cytochrome c, testis IEA KEGG rno:05210 NCBI chr 3:61,290,090...61,297,158
Ensembl chr 3:81,697,333...81,700,514 		JBrowse link
G Dcc DCC netrin 1 receptor IEA KEGG rno:05210 NCBI chr18:67,144,272...68,248,159
Ensembl chr18:67,149,179...68,247,541 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:05210 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:05210 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IEA KEGG rno:05210 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Kras KRAS proto-oncogene, GTPase TAS
IEA 		KEGG
RGD		 PMID:16112461 rno:05210, RGD:2306732 NCBI chr 4:179,916,255...179,949,613
Ensembl chr 4:179,919,802...179,949,320 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 IEA KEGG rno:05210 NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:222,340,704...222,453,929 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA KEGG rno:05210 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:05210 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:05210 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:05210 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:05210 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:05210 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mlh1 mutL homolog 1 ISO
IEA 		KEGG
RGD		 PMID:11900875 rno:05210, RGD:2306714 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011 		JBrowse link
G Msh2 mutS homolog 2 ISO
IEA 		KEGG
RGD		 PMID:11900875 rno:05210, RGD:2306714 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503 		JBrowse link
G Msh3 mutS homolog 3 IEA KEGG rno:05210 NCBI chr 2:25,179,400...25,320,857
Ensembl chr 2:25,179,400...25,321,102 		JBrowse link
G Msh6 mutS homolog 6 ISO RGD PMID:11900875 RGD:2306714 NCBI chr 6:12,316,190...12,333,505
Ensembl chr 6:12,316,198...12,333,844 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor IEA KEGG rno:05210 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:05210 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05210 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05210 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05210 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05210 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05210 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05210 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Pms1 PMS1 homolog 1, mismatch repair system component ISO RGD PMID:11900875 RGD:2306714 NCBI chr 9:55,721,393...55,832,225
Ensembl chr 9:55,745,374...55,832,221 		JBrowse link
G Pms2 PMS1 homolog 2, mismatch repair system component ISO RGD PMID:11900875 RGD:2306714 NCBI chr12:15,790,478...15,814,790
Ensembl chr12:15,790,478...15,815,248 		JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG rno:05210 NCBI chr12:16,150,411...16,170,864
Ensembl chr12:16,128,649...16,172,109 		JBrowse link
G Rac2 Rac family small GTPase 2 IEA KEGG rno:05210 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA KEGG rno:05210 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813 		JBrowse link
G Ralgds ral guanine nucleotide dissociation stimulator IEA KEGG rno:05210 NCBI chr 3:32,237,644...32,278,045
Ensembl chr 3:32,237,786...32,278,045 		JBrowse link
G Rhoa ras homolog family member A IEA KEGG rno:05210 NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:117,870,270...117,904,302 		JBrowse link
G Rhoal1 ras homolog family member A like 1 IEA KEGG rno:05210 NCBI chr 4:96,581,411...96,582,783
Ensembl chr 4:96,581,383...96,582,775 		JBrowse link
G Smad2 SMAD family member 2 ISO
IEA 		KEGG
RGD		 PMID:17613544 PMID:18662538 rno:05210, RGD:2306282, RGD:2308865 NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388 		JBrowse link
G Smad3 SMAD family member 3 ISO
IEA 		KEGG
RGD		 PMID:17613544 rno:05210, RGD:2306282 NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:73,024,760...73,132,324 		JBrowse link
G Smad4 SMAD family member 4 ISO
IEA 		KEGG
RGD		 PMID:17613544 PMID:18662538 rno:05210, RGD:2306282, RGD:2308865 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:69,518,988...69,549,684 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:71,263,508...71,291,849
Ensembl chr18:71,263,508...71,291,849 		JBrowse link
G Tcf3 transcription factor 3 IEA KEGG rno:05210 NCBI chr 7:9,931,251...9,952,994
Ensembl chr 7:9,928,685...9,953,044 		JBrowse link
G Tcf7 transcription factor 7 IEA KEGG rno:05210 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 IEA KEGG rno:05210 NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:264,791,335...264,984,225 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO
IEA 		KEGG
RGD		 PMID:17613544 rno:05210, RGD:2306282 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEA KEGG rno:05210 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:100,692,953...100,792,856 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEA KEGG rno:05210 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:111,435,170...111,456,946 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO
IEA 		KEGG
RGD		 PMID:17613544 rno:05210, RGD:2306282 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO
IEA 		KEGG
RGD		 PMID:17613544 PMID:18662538 rno:05210, RGD:2306282, RGD:2308865 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:124,674,986...124,761,469 		JBrowse link
G Tp53 tumor protein p53 IEA KEGG rno:05210 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      cancer pathway 369
        digestive system cancer pathway 113
          gastrointestinal cancer pathway 64
            colorectal cancer pathway 64
paths to the root