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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron homeostasis pathway
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Accession:PW:0000590 term browser browse the term
Definition:Those pathways involved in the proper balance of iron levels, uptake and transport, utilization and storage as needed by cells, tissues and organs. Iron is essential for many life processes but its reactivity makes it potentially dangerous.
Synonyms:related_synonym: iron ion homeostasis
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show annotations for term's descendants           Sort by:
iron homeostasis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aco1 aconitase 1 ISO RGD PMID:25661197 RGD:11554199 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Fbxl5 F-box and leucine-rich repeat protein 5 ISO RGD PMID:25661197 RGD:11554199 NCBI chr14:67,305,109...67,347,383
Ensembl chr14:67,267,801...67,347,383 		JBrowse link
G Ireb2 iron responsive element binding protein 2 ISO RGD PMID:25661197 RGD:11554199 NCBI chr 8:55,228,080...55,311,613
Ensembl chr 8:55,228,085...55,311,611 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641 		JBrowse link
G Pcbp1 poly(rC) binding protein 1 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863 		JBrowse link
G Pcbp3 poly(rC) binding protein 3 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr20:11,678,218...11,878,210
Ensembl chr20:11,678,269...11,878,210 		JBrowse link
G Pcbp4 poly(rC) binding protein 4 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr 8:107,092,688...107,103,276
Ensembl chr 8:107,093,013...107,103,276 		JBrowse link
cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ciao1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 3:114,458,671...114,465,928
Ensembl chr 3:114,458,655...114,467,009 		JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 8:66,670,533...66,682,455
Ensembl chr 8:66,670,483...66,682,455 		JBrowse link
G Ciao2b cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr19:344,194...346,068
Ensembl chr19:344,203...346,068 		JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr10:14,795,888...14,804,953
Ensembl chr10:14,795,961...14,804,950 		JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr19:10,179,963...10,195,511
Ensembl chr19:10,180,100...10,195,503 		JBrowse link
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 1:240,757,279...240,794,291
Ensembl chr 1:240,757,282...240,794,288 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr 3:8,062,629...8,070,873
Ensembl chr 3:8,062,630...8,070,860 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr10:5,259,328...5,270,848 JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190, RGD:11554192 NCBI chr10:13,903,224...13,906,928
Ensembl chr10:13,903,224...13,906,969 		JBrowse link
heme biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase IEA
ISO		 RGD PMID: PMID:26785297 PMID:16839620 RGD:1578396, RGD:11554188, RGD:4144542 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 IEA
ISO
IDA		 RGD PMID: PMID:26785297 PMID:16839620 PMID:16125296 RGD:1578396, RGD:11554188, RGD:4144542, RGD:1601233 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 IEA
ISO		 RGD PMID: PMID:26785297 PMID:16839620 RGD:1578396, RGD:11554188, RGD:4144542 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519 		JBrowse link
G Cpox coproporphyrinogen oxidase IEA
ISO		 RGD PMID: PMID:26785297 PMID:16839620 RGD:1578396, RGD:11554188, RGD:4144542 NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746 		JBrowse link
G Fech ferrochelatase IEA
ISO		 RGD PMID: PMID:26785297 PMID:16839620 RGD:1578396, RGD:11554188, RGD:4144542 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G Hmbs hydroxymethylbilane synthase IEA
IDA
IMP
ISO		 RGD PMID: PMID:593266 PMID:6694518 PMID:1781034 PMID:6893114 More... RGD:1578396, RGD:26884337, RGD:25330343, RGD:25440495, RGD:26923963, RGD:11554188, RGD:4144542, RGD:2301704 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957 		JBrowse link
G Ppox protoporphyrinogen oxidase IEA
ISO
IDA		 RGD PMID: PMID:26785297 PMID:16839620 PMID:3663105 RGD:1578396, RGD:11554188, RGD:4144542, RGD:1599180 NCBI chr13:83,697,661...83,701,998
Ensembl chr13:83,664,891...83,701,805 		JBrowse link
G Slc25a38 solute carrier family 25, member 38 ISO RGD PMID:26785297 PMID:27476175 RGD:11554188, RGD:11556278 NCBI chr 8:119,835,546...119,848,334
Ensembl chr 8:119,835,634...119,848,332 		JBrowse link
G Tspo translocator protein ISO RGD PMID:26785297 RGD:11554188 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450 		JBrowse link
G Urod uroporphyrinogen decarboxylase IEA
ISO
IDA		 RGD PMID: PMID:26785297 PMID:16839620 PMID:10416273 RGD:1578396, RGD:11554188, RGD:4144542, RGD:2303399 NCBI chr 5:130,464,695...130,468,783
Ensembl chr 5:130,455,217...130,468,808 		JBrowse link
G Uros uroporphyrinogen III synthase IEA
ISO
TAS		 RGD PMID: PMID:26785297 PMID:3327431 PMID:16839620 RGD:1578396, RGD:11554188, RGD:4144823, RGD:4144542 NCBI chr 1:188,490,832...188,513,659
Ensembl chr 1:188,490,323...188,512,249 		JBrowse link
iron efflux pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cp ceruloplasmin ISO RGD PMID:26437604 RGD:11534369 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Hamp hepcidin antimicrobial peptide ISO RGD PMID:26437604 RGD:11534369 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Heph hephaestin ISO RGD PMID:26437604 RGD:11534369 NCBI chr  X:61,151,131...61,402,980
Ensembl chr  X:61,296,345...61,402,980 		JBrowse link
G Slc40a1 solute carrier family 40 member 1 ISO RGD PMID:26437604 RGD:11534369 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481 		JBrowse link
iron storage pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fth1 ferritin heavy chain 1 ISO RGD PMID:25661197 PMID:25119494 RGD:11554199, RGD:11556277 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 ISO RGD PMID:25661197 PMID:25119494 RGD:11554199, RGD:11556277 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725
Ensembl chr 2:95,936,387...95,939,725 		JBrowse link
G Ftmt ferritin mitochondrial ISO RGD PMID:25661197 RGD:11554199 NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123 		JBrowse link
G Pcbp1 poly(rC) binding protein 1 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500 		JBrowse link
G Pcbp2 poly(rC) binding protein 2 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863 		JBrowse link
iron uptake pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cybrd1 cytochrome b reductase 1 ISO RGD PMID:25661197 RGD:11554199 NCBI chr 3:55,934,874...55,962,132
Ensembl chr 3:55,934,874...55,962,108 		JBrowse link
G Prnp prion protein ISO RGD PMID:26725301 RGD:11556274 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
G Slc11a2 solute carrier family 11 member 2 ISO RGD PMID:25661197 RGD:11554199 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145 		JBrowse link
G Slc25a28 solute carrier family 25 member 28 ISO RGD PMID:25661197 RGD:11554199 NCBI chr 1:242,530,877...242,542,140
Ensembl chr 1:242,530,899...242,542,115 		JBrowse link
G Slc25a37 solute carrier family 25 member 37 ISO RGD PMID:25661197 RGD:11554199 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199 		JBrowse link
G Slc39a14 solute carrier family 39 member 14 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524 		JBrowse link
G Slc39a8 solute carrier family 39 member 8 ISO RGD PMID:25661197 PMID:26725301 RGD:11554199, RGD:11556274 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129 		JBrowse link
G Steap3 STEAP3 metalloreductase ISO RGD PMID:25661197 RGD:11554199 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tf transferrin ISO RGD PMID:25661197 RGD:11554199 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tfrc transferrin receptor ISO RGD PMID:25661197 RGD:11554199 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chr  X:69,295,598...69,436,775
Ensembl chr  X:69,295,552...69,436,858 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bola3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797 		JBrowse link
G Fdx1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414 		JBrowse link
G Fdx2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849 		JBrowse link
G Fdxr ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658 		JBrowse link
G Glrx5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:123,988,461...123,998,545
Ensembl chr 6:123,988,134...123,998,545 		JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster co-chaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:45,821,527...45,831,902
Ensembl chr12:45,821,555...45,831,909 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292 		JBrowse link
G Iba57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chr10:43,942,017...43,950,807
Ensembl chr10:43,942,017...43,950,807 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955 		JBrowse link
G Isca2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:104,418,509...104,420,019
Ensembl chr 6:104,418,454...104,420,045
Ensembl chr14:104,418,454...104,420,045 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150 		JBrowse link
G Lyrm4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:28,746,457...28,861,849
Ensembl chr17:28,746,469...28,861,750 		JBrowse link
G Nfs1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373 		JBrowse link
G Nubpl NUBP iron-sulfur cluster assembly factor like ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:69,559,278...69,781,254
Ensembl chr 6:69,559,291...69,781,253 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3867
      homeostasis pathway 1773
        inorganic chemical homeostasis pathway 430
          metal homeostasis pathway 339
            iron homeostasis pathway 62
              altered iron homeostasis pathway 0
              iron storage pathway 5
              iron transport pathway + 14
              iron utilization pathway + 37
paths to the root