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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:signaling pathway involving second messengers
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Accession:PW:0000541 term browser browse the term


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adenosine monophosphate-activated protein kinase (AMPK) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cab39 calcium binding protein 39 TAS
IDA
RGD PMID:15509864, PMID:14511394 RGD:1600678, RGD:1600691 NCBI chr 9:92,834,327...92,895,778
Ensembl chr 9:92,834,357...92,895,778
JBrowse link
G Calm1 calmodulin 1 ISO RGD PMID:16054095 RGD:2311420 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 ISO RGD PMID:16054095 RGD:2311420 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 ISO RGD PMID:16054095 RGD:2311420 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Camkk1 calcium/calmodulin-dependent protein kinase kinase 1 IDA RGD PMID:16054095 RGD:2311420 NCBI chr10:59,585,023...59,608,180
Ensembl chr10:59,585,072...59,608,165
JBrowse link
G Camkk2 calcium/calmodulin-dependent protein kinase kinase 2 IDA RGD PMID:16054095 RGD:2311420 NCBI chr12:39,253,409...39,302,601
Ensembl chr12:39,253,409...39,302,601
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A IEP RGD PMID:30868489 RGD:25823184 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Ppm1e protein phosphatase, Mg2+/Mn2+ dependent, 1E ISO RGD PMID:20801214 RGD:7794756 NCBI chr10:74,548,270...74,679,858
Ensembl chr10:74,548,270...74,679,858
JBrowse link
G Ppm1f protein phosphatase, Mg2+/Mn2+ dependent, 1F ISO RGD PMID:20801214 RGD:7794756 NCBI chr11:88,313,709...88,343,726
Ensembl chr11:88,313,709...88,343,627
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha ISO RGD PMID:21782450 RGD:7794757 NCBI chr 1:219,439,953...219,443,570
Ensembl chr 1:219,439,953...219,443,570
JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta ISO RGD PMID:21782450 RGD:7794757 NCBI chr 6:23,548,507...23,581,136
Ensembl chr 6:23,549,317...23,581,052
JBrowse link
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D ISO RGD PMID:21782450 RGD:7794757 NCBI chr 3:173,950,613...173,953,684
Ensembl chr 3:173,950,613...173,953,684
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:21782450 RGD:7794757 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 ISO
IDA
RGD PMID:15509864, PMID:14511394, PMID:12829246 RGD:1600678, RGD:1600691, RGD:1600679 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 ISO
IDA
RGD PMID:15509864, PMID:14511394, PMID:12829246 RGD:1600678, RGD:1600691, RGD:1600679 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 ISO RGD PMID:15509864, PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr12:46,316,298...46,326,789
Ensembl chr12:46,316,236...46,326,790
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 ISO RGD PMID:15509864, PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629
JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 ISO
IDA
RGD PMID:15509864, PMID:14511394, PMID:12829246 RGD:1600678, RGD:1600691, RGD:1600679 NCBI chr 7:140,489,499...140,506,925
Ensembl chr 7:140,489,492...140,546,908
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 ISO RGD PMID:15509864, PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 ISO RGD PMID:15509864, PMID:12829246 RGD:1600678, RGD:1600679 NCBI chr 9:81,999,368...82,008,620
Ensembl chr 9:81,999,376...82,008,620
JBrowse link
G Stk11 serine/threonine kinase 11 TAS
IDA
RGD PMID:15509864, PMID:14511394 RGD:1600678, RGD:1600691 NCBI chr 7:12,440,751...12,457,513
Ensembl chr 7:12,440,751...12,457,513
JBrowse link
G Strada STE20 related adaptor alpha TAS
IDA
RGD PMID:15509864, PMID:14511394 RGD:1600678, RGD:1600691 NCBI chr10:94,355,369...94,384,404
Ensembl chr10:94,355,384...94,384,339
JBrowse link
G Tsc1 TSC complex subunit 1 IEP RGD PMID:31787541 RGD:25823196 NCBI chr 3:7,219,955...7,269,063
Ensembl chr 3:7,237,192...7,265,145
JBrowse link
altered phosphatidylinositol 3-kinase signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:23759327 RGD:8693397 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:23759327 RGD:8693397 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:18955974, PMID:21277552 RGD:2313763, RGD:5133243 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:18955974, PMID:15166380, PMID:19506583 RGD:2313763, RGD:2313408, RGD:5490965 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO RGD PMID:18955974 RGD:2313763 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:18955974, PMID:21277552, PMID:20951313, PMID:19078924 RGD:2313763, RGD:5133243, RGD:5133242, RGD:4143515 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:18955974, PMID:19506583, PMID:20951313, PMID:19078924, PMID:18008377 RGD:2313763, RGD:5490965, RGD:5133242, RGD:4143515, RGD:2326139 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
ceramide signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 ISO PID PID:200119 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IEA KEGG rno:05212 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:05212 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Arhgef6 Rac/Cdc42 guanine nucleotide exchange factor 6 IEA KEGG rno:05212 NCBI chr  X:159,722,031...159,841,344
Ensembl chr  X:159,723,866...159,841,072
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 ISO PID PID:200119 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Bad BCL2-associated agonist of cell death ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bag4 BAG cochaperone 4 ISO PID PID:200119 NCBI chr16:71,057,709...71,075,874
Ensembl chr16:71,058,022...71,075,320
JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO PID PID:200119 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO PID PID:200119 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 IEA KEGG rno:05212 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bid BH3 interacting domain death agonist ISO PID PID:200119 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 ISO PID PID:200119 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IEA KEGG rno:05212 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Brca2 BRCA2, DNA repair associated IEA KEGG rno:05212 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
G Casp8 caspase 8 ISO PID PID:200119 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 IEA KEGG rno:05212 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccnd1 cyclin D1 IEA KEGG rno:05212 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc42 cell division cycle 42 IEA KEGG rno:05212 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdk4 cyclin-dependent kinase 4 IEA KEGG rno:05212 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk6 cyclin-dependent kinase 6 IEA KEGG rno:05212 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A IEA KEGG rno:05212 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex IEA KEGG rno:05212 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain ISO PID PID:200119 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Ctsd cathepsin D ISO PID PID:200119 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cycs cytochrome c, somatic ISO PID PID:200119 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G E2f1 E2F transcription factor 1 IEA KEGG rno:05212 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f3 E2F transcription factor 3 IEA KEGG rno:05212 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Egf epidermal growth factor ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor IEA KEGG rno:05212 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO PID PID:200119 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 ISO PID PID:200119 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IEA KEGG rno:05212 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Fadd Fas associated via death domain ISO PID PID:200119 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Igf1 insulin-like growth factor 1 ISO PID PID:200119 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:05212 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma IEA KEGG rno:05212 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Jak1 Janus kinase 1 IEA KEGG rno:05212 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:05212 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Ksr1 kinase suppressor of ras 1 ISO PID PID:200119 NCBI chr10:66,323,704...66,342,469
NCBI chr10:66,346,100...66,482,396
Ensembl chr10:66,347,358...66,482,150
JBrowse link
G Madd MAP-kinase activating death domain ISO PID PID:200119 NCBI chr 3:79,960,301...80,003,023
Ensembl chr 3:79,960,301...80,003,032
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 ISO PID PID:200119 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 ISO PID PID:200119 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200119 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ISO PID PID:200119 NCBI chr 9:46,657,444...46,782,545
Ensembl chr 9:46,657,575...46,782,545
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:05212 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:05212 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor ISO PID PID:200119 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkbia NFKB inhibitor alpha ISO PID PID:200119 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor ISO PID PID:200119 NCBI chr 5:19,499,111...19,560,308
Ensembl chr 5:19,499,480...19,559,393
JBrowse link
G Pawr pro-apoptotic WT1 regulator ISO PID PID:200119 NCBI chr 7:51,273,764...51,353,700
Ensembl chr 7:51,273,771...51,353,068
JBrowse link
G Pdgfa platelet derived growth factor subunit A ISO PID PID:200119 NCBI chr12:17,734,141...17,756,186
Ensembl chr12:17,734,133...17,755,285
JBrowse link
G Pgf placental growth factor IEA KEGG rno:05212 NCBI chr 6:108,994,016...109,004,598
Ensembl chr 6:108,994,018...109,004,598
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:05212 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:05212 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:05212 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:05212 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:05212 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:05212 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:05212 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pld1 phospholipase D1 IEA KEGG rno:05212 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Prkcd protein kinase C, delta ISO PID PID:200119 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkcz protein kinase C, zeta ISO PID PID:200119 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Prkra protein activator of interferon induced protein kinase EIF2AK2 ISO PID PID:200119 NCBI chr 3:63,489,081...63,507,918
Ensembl chr 3:63,489,074...63,507,926
JBrowse link
G Rac1 Rac family small GTPase 1 IEA KEGG rno:05212 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rac2 Rac family small GTPase 2 IEA KEGG rno:05212 NCBI chr 7:119,769,708...119,797,111
Ensembl chr 7:119,783,849...119,797,098
JBrowse link
G Rad51 RAD51 recombinase IEA KEGG rno:05212 NCBI chr 3:110,918,240...110,942,920
Ensembl chr 3:110,918,243...110,942,917
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rala RAS like proto-oncogene A IEA KEGG rno:05212 NCBI chr17:49,676,073...49,729,133
Ensembl chr17:49,714,294...49,727,664
JBrowse link
G Ralb RAS like proto-oncogene B IEA KEGG rno:05212 NCBI chr13:35,494,716...35,531,503
Ensembl chr13:35,494,721...35,511,020
JBrowse link
G Ralbp1 ralA binding protein 1 IEA KEGG rno:05212 NCBI chr 9:113,579,107...113,598,477
Ensembl chr 9:113,579,107...113,598,480
JBrowse link
G Ralgds ral guanine nucleotide dissociation stimulator IEA KEGG rno:05212 NCBI chr 3:7,090,134...7,130,548
Ensembl chr 3:7,109,920...7,130,548
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO
IEA
PID
KEGG
PID:200119, rno:05212 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID PID:200119 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Smad2 SMAD family member 2 IEA KEGG rno:05212 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 IEA KEGG rno:05212 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 IEA KEGG rno:05212 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200119 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 ISO PID PID:200119 NCBI chr19:38,237,963...38,321,572
Ensembl chr19:38,237,965...38,321,528
JBrowse link
G Sphk2 sphingosine kinase 2 ISO PID PID:200119 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Stat1 signal transducer and activator of transcription 1 IEA KEGG rno:05212 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 IEA KEGG rno:05212 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tgfa transforming growth factor alpha IEA KEGG rno:05212 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEA KEGG rno:05212 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEA KEGG rno:05212 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 IEA KEGG rno:05212 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 IEA KEGG rno:05212 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 IEA KEGG rno:05212 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tnf tumor necrosis factor ISO PID PID:200119 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO PID PID:200119 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tp53 tumor protein p53 IEA KEGG rno:05212 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tradd TNFRSF1A-associated via death domain ISO PID PID:200119 NCBI chr19:37,214,461...37,221,099
Ensembl chr19:37,214,471...37,216,572
JBrowse link
G Traf2 Tnf receptor-associated factor 2 ISO PID PID:200119 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link
G Vegfa vascular endothelial growth factor A IEA KEGG rno:05212 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B IEA KEGG rno:05212 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Vegfc vascular endothelial growth factor C IEA KEGG rno:05212 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576
JBrowse link
G Vegfd vascular endothelial growth factor D IEA KEGG rno:05212 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
phosphatidylinositol 3-kinase class I signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adap1 ArfGAP with dual PH domains 1 ISO PID PID:200116 NCBI chr12:17,416,327...17,468,212
Ensembl chr12:17,416,327...17,468,212
JBrowse link
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 ISO PID PID:200116 NCBI chr18:31,112,083...31,138,142
Ensembl chr18:31,112,623...31,136,200
JBrowse link
G Arf1 ADP-ribosylation factor 1 ISO PID PID:200116 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arf5 ADP-ribosylation factor 5 ISO PID PID:200116 NCBI chr 4:55,715,744...55,718,670
Ensembl chr 4:55,715,744...55,718,670
JBrowse link
G Arf6 ADP-ribosylation factor 6 ISO PID PID:200116 NCBI chr 6:91,697,109...91,698,257
Ensembl chr 6:91,697,109...91,698,255
JBrowse link
G Blk BLK proto-oncogene, Src family tyrosine kinase ISO PID PID:200116 NCBI chr15:46,555,552...46,593,778
Ensembl chr15:46,555,188...46,593,653
JBrowse link
G Blnk B-cell linker ISO PID PID:200116 NCBI chr 1:260,187,023...260,254,490
Ensembl chr 1:260,186,967...260,254,600
JBrowse link
G Btk Bruton tyrosine kinase ISO PID PID:200116 NCBI chr  X:105,360,922...105,390,580
Ensembl chr  X:105,360,922...105,390,580
JBrowse link
G Cyth1 cytohesin 1 ISO PID PID:200116 NCBI chr10:107,197,983...107,281,285
Ensembl chr10:107,197,989...107,281,235
JBrowse link
G Cyth2 cytohesin 2 ISO PID PID:200116 NCBI chr 1:101,796,349...101,803,407
Ensembl chr 1:101,796,349...101,803,200
JBrowse link
G Cyth3 cytohesin 3 ISO PID PID:200116 NCBI chr12:12,877,559...12,907,771
Ensembl chr12:12,877,559...12,945,192
JBrowse link
G Dapp1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1 ISO PID PID:200116 NCBI chr 2:243,175,346...243,224,883
Ensembl chr 2:243,175,346...243,224,883
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase ISO PID PID:200116 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Foxo3 forkhead box O3 ISO PID PID:200116 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200116 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200116 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033
JBrowse link
G Hras HRas proto-oncogene, GTPase ISO PID PID:200116 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200116 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO PID PID:200116 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO PID PID:200116 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Itk IL2-inducible T-cell kinase ISO PID PID:200116 NCBI chr10:31,431,820...31,493,413
Ensembl chr10:31,431,809...31,493,419
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO PID PID:200116 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase ISO PID PID:200116 NCBI chr 5:16,526,058...16,642,648
Ensembl chr 5:16,526,058...16,642,648
JBrowse link
G Nras NRAS proto-oncogene, GTPase ISO PID PID:200116 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200116 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200116 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO PID PID:200116 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO PID PID:200116 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO PID PID:200116 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200116 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200116 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO PID PID:200116 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 ISO PID PID:200116 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 ISO PID PID:200116 NCBI chr10:55,085,269...55,135,069
Ensembl chr10:55,085,259...55,135,092
JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO PID PID:200116 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Plcg2 phospholipase C, gamma 2 ISO PID PID:200116 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 ISO PID PID:200116 NCBI chr 1:201,429,716...201,481,411
Ensembl chr 1:201,429,771...201,480,877
JBrowse link
G Plekha2 pleckstrin homology domain containing A2 ISO PID PID:200116 NCBI chr16:71,725,649...71,784,432
Ensembl chr16:71,738,718...71,787,787
JBrowse link
G Pten phosphatase and tensin homolog ISO PID PID:200116 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200116 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PID PID:200116 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200116 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200116 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200116 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200116 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Yes1 YES proto-oncogene 1, Src family tyrosine kinase ISO PID PID:200116 NCBI chr 9:121,802,471...121,918,906
Ensembl chr 9:121,802,673...121,902,678
JBrowse link
G Zap70 zeta chain of T cell receptor associated protein kinase 70 ISO PID PID:200116 NCBI chr 9:43,331,149...43,353,097
Ensembl chr 9:43,331,155...43,353,113
JBrowse link
phosphatidylinositol 3-kinase signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm1 calmodulin 1 IEA KEGG rno:04070 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
JBrowse link
G Calm2 calmodulin 2 IEA KEGG rno:04070 NCBI chr 6:11,067,675...11,080,078
Ensembl chr15:65,506,874...65,507,968
JBrowse link
G Calm3 calmodulin 3 IEA KEGG rno:04070 NCBI chr 1:78,844,520...78,851,628
Ensembl chr 1:78,843,080...78,851,719
JBrowse link
G Calml3 calmodulin-like 3 IEA KEGG rno:04070 NCBI chr17:70,070,458...70,073,697
Ensembl chr17:70,072,156...70,073,530
JBrowse link
G Calml5 calmodulin-like 5 IEA KEGG rno:04070 NCBI chr17:70,044,956...70,045,886 JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase IEA KEGG rno:04070 NCBI chr 1:198,409,186...198,413,497
Ensembl chr 1:198,409,360...198,413,497
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 IEA KEGG rno:04070 NCBI chr14:9,396,511...9,456,964
Ensembl chr14:9,396,512...9,456,990
JBrowse link
G Cds2 CDP-diacylglycerol synthase 2 IEA KEGG rno:04070 NCBI chr 3:124,896,657...124,935,221
Ensembl chr 3:124,896,618...124,935,226
JBrowse link
G Dgka diacylglycerol kinase, alpha IEA KEGG rno:04070 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dgkb diacylglycerol kinase, beta IEA KEGG rno:04070 NCBI chr 6:57,516,351...58,277,385
Ensembl chr 6:57,516,713...58,277,279
JBrowse link
G Dgkd diacylglycerol kinase, delta IEA KEGG rno:04070 NCBI chr 9:94,980,328...95,071,531
Ensembl chr 9:94,980,409...95,069,714
JBrowse link
G Dgkg diacylglycerol kinase, gamma IEA KEGG rno:04070 NCBI chr11:81,971,585...82,165,111
Ensembl chr11:81,972,219...82,163,165
JBrowse link
G Dgki diacylglycerol kinase, iota IEA KEGG rno:04070 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473
JBrowse link
G Dgkq diacylglycerol kinase, theta IEA KEGG rno:04070 NCBI chr14:2,069,409...2,083,370
Ensembl chr14:2,069,409...2,083,370
JBrowse link
G Dgkz diacylglycerol kinase zeta IEA KEGG rno:04070 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Impa1 inositol monophosphatase 1 IEA KEGG rno:04070 NCBI chr 2:93,675,203...93,696,355
Ensembl chr 2:93,675,203...93,696,232
JBrowse link
G Impa2 inositol monophosphatase 2 IEA KEGG rno:04070 NCBI chr18:63,016,577...63,050,123
Ensembl chr18:63,016,577...63,047,781
JBrowse link
G Inpp1 inositol polyphosphate-1-phosphatase IEA KEGG rno:04070 NCBI chr 9:53,544,602...53,574,303
Ensembl chr 9:53,546,018...53,574,690
JBrowse link
G Inpp4a inositol polyphosphate-4-phosphatase type I A IEA KEGG rno:04070 NCBI chr 9:43,889,887...44,006,593
Ensembl chr 9:43,889,473...44,004,325
JBrowse link
G Inpp4b inositol polyphosphate-4-phosphatase type II B IEA KEGG rno:04070 NCBI chr19:29,592,889...30,341,528
Ensembl chr19:29,597,905...29,968,424
JBrowse link
G Inpp5a inositol polyphosphate-5-phosphatase A IEA KEGG rno:04070 NCBI chr 1:211,732,163...211,920,844
Ensembl chr 1:211,732,713...211,921,099
JBrowse link
G Inpp5b inositol polyphosphate-5-phosphatase B IEA KEGG rno:04070 NCBI chr 5:142,731,767...142,796,305
Ensembl chr 5:142,731,767...142,796,305
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D IEA KEGG rno:04070 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771
JBrowse link
G Inpp5j inositol polyphosphate-5-phosphatase J IEA KEGG rno:04070 NCBI chr14:83,730,861...83,742,016
Ensembl chr14:83,730,862...83,741,969
JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K IEA KEGG rno:04070 NCBI chr10:63,775,639...63,796,879
Ensembl chr10:63,776,378...63,795,899
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 IEA KEGG rno:04070 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Ippk inositol-pentakisphosphate 2-kinase IEA KEGG rno:04070 NCBI chr17:15,604,148...15,643,312
Ensembl chr17:15,604,145...15,643,489
JBrowse link
G Itpk1 inositol-tetrakisphosphate 1-kinase IEA KEGG rno:04070 NCBI chr 6:126,448,920...126,582,188
Ensembl chr 6:126,450,139...126,582,134
JBrowse link
G Itpka inositol-trisphosphate 3-kinase A IEA KEGG rno:04070 NCBI chr 3:111,545,007...111,553,605
Ensembl chr 3:111,545,007...111,553,604
JBrowse link
G Itpkb inositol-trisphosphate 3-kinase B IEA KEGG rno:04070 NCBI chr13:98,615,287...98,710,426
Ensembl chr13:98,615,287...98,708,149
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 IEA KEGG rno:04070 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 IEA KEGG rno:04070 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G Itpr3 inositol 1,4,5-trisphosphate receptor, type 3 IEA KEGG rno:04070 NCBI chr20:5,645,894...5,711,702
Ensembl chr20:5,646,097...5,711,702
JBrowse link
G Ocrl OCRL, inositol polyphosphate-5-phosphatase IEA KEGG rno:04070 NCBI chr  X:134,742,226...134,793,411
Ensembl chr  X:134,742,356...134,792,618
JBrowse link
G Pi4k2a phosphatidylinositol 4-kinase type 2 alpha IEA KEGG rno:04070 NCBI chr 1:261,337,594...261,362,509
Ensembl chr 1:261,337,594...261,362,509
JBrowse link
G Pi4k2b phosphatidylinositol 4-kinase type 2 beta IEA KEGG rno:04070 NCBI chr14:60,567,968...60,594,821
Ensembl chr14:60,567,967...60,594,844
JBrowse link
G Pi4ka phosphatidylinositol 4-kinase alpha IEA KEGG rno:04070 NCBI chr11:87,858,323...87,975,549
Ensembl chr11:87,858,453...87,973,422
JBrowse link
G Pi4kb phosphatidylinositol 4-kinase beta IEA KEGG rno:04070 NCBI chr 2:196,139,724...196,172,055
Ensembl chr 2:196,139,755...196,171,713
JBrowse link
G Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha IEA KEGG rno:04070 NCBI chr 1:185,210,922...185,326,314
Ensembl chr 1:185,210,922...185,326,314
JBrowse link
G Pik3c2b phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta IEA KEGG rno:04070 NCBI chr13:49,848,939...49,909,404
Ensembl chr13:49,850,189...49,911,202
JBrowse link
G Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma IEA KEGG rno:04070 NCBI chr 4:173,732,196...174,102,502
Ensembl chr 4:173,732,248...174,102,496
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 IEA KEGG rno:04070 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04070 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04070 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04070 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04070 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04070 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04070 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04070 NCBI chr10:55,013,686...55,078,986
Ensembl chr10:55,013,703...55,080,421
JBrowse link
G Pikfyve phosphoinositide kinase, FYVE-type zinc finger containing IEA KEGG rno:04070 NCBI chr 9:71,911,744...72,005,816
Ensembl chr 9:71,915,421...72,005,838
JBrowse link
G Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha IEA KEGG rno:04070 NCBI chr17:85,533,056...85,748,843 JBrowse link
G Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta IEA KEGG rno:04070 NCBI chr10:85,655,223...85,684,138
Ensembl chr10:85,658,324...85,684,138
JBrowse link
G Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma IEA KEGG rno:04070 NCBI chr 7:70,483,948...70,498,995
Ensembl chr 7:70,483,942...70,498,995
JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha IEA KEGG rno:04070 NCBI chr 2:196,227,669...196,270,949
Ensembl chr 2:196,227,670...196,270,826
JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta IEA KEGG rno:04070 NCBI chr 1:242,168,462...242,441,247
Ensembl chr 1:242,168,462...242,441,247
JBrowse link
G Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma IEA KEGG rno:04070 NCBI chr 7:11,267,207...11,294,291
Ensembl chr 7:11,267,218...11,294,249
JBrowse link
G Plcb1 phospholipase C beta 1 IEA KEGG rno:04070 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb2 phospholipase C, beta 2 IEA KEGG rno:04070 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Plcb3 phospholipase C beta 3 IEA KEGG rno:04070 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcb4 phospholipase C, beta 4 IEA KEGG rno:04070 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Plcd1 phospholipase C, delta 1 IEA KEGG rno:04070 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plcd3 phospholipase C, delta 3 IEA KEGG rno:04070 NCBI chr10:91,164,778...91,186,067
Ensembl chr10:91,164,812...91,186,054
JBrowse link
G Plcd4 phospholipase C, delta 4 IEA KEGG rno:04070 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
JBrowse link
G Plce1 phospholipase C, epsilon 1 IEA KEGG rno:04070 NCBI chr 1:257,156,023...257,465,440
Ensembl chr 1:257,157,264...257,466,064
JBrowse link
G Plcg1 phospholipase C, gamma 1 IEA KEGG rno:04070 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Plcg2 phospholipase C, gamma 2 IEA KEGG rno:04070 NCBI chr19:50,039,410...50,173,543
Ensembl chr19:50,045,020...50,173,220
JBrowse link
G Plcz1 phospholipase C, zeta 1 IEA KEGG rno:04070 NCBI chr 4:174,125,072...174,181,524
Ensembl chr 4:174,125,178...174,180,729
JBrowse link
G Prkca protein kinase C, alpha IEA KEGG rno:04070 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta IEA KEGG rno:04070 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcg protein kinase C, gamma IEA KEGG rno:04070 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Pten phosphatase and tensin homolog IEA KEGG rno:04070 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Sec16a SEC16 homolog A, endoplasmic reticulum export factor IEA KEGG rno:04070 NCBI chr 3:3,856,218...3,890,785
Ensembl chr 3:3,856,218...3,890,758
JBrowse link
G Synj1 synaptojanin 1 IEA KEGG rno:04070 NCBI chr11:31,105,784...31,181,573
Ensembl chr11:31,104,787...31,180,642
JBrowse link
G Synj2 synaptojanin 2 IEA KEGG rno:04070 NCBI chr 1:46,835,922...46,932,544
Ensembl chr 1:46,835,971...46,932,529
JBrowse link
phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PMID:17641274, PMID:12084817 PID:200197, RGD:2290458, RGD:625444 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 IMP
ISO
PID PMID:12089343, PMID:17641274 PID:200197, RGD:632179, RGD:2290458 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO PID PMID:17641274 PID:200197, RGD:2290458 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Bad BCL2-associated agonist of cell death ISO PID PID:200197 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Casp9 caspase 9 ISO PID PID:200197 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO PID PID:200197 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B ISO PID PID:200197 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200197 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Foxo1 forkhead box O1 ISO PID PID:200197 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 ISO PID PID:200197 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Foxo4 forkhead box O4 ISO PID PID:200197 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha ISO PID PID:200197 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200197 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO PID PID:200197 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO RGD PMID:17371235 RGD:2302068 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771
JBrowse link
G Inppl1 inositol polyphosphate phosphatase-like 1 ISO RGD PMID:17371235 RGD:2302068 NCBI chr 1:166,898,177...166,912,524
Ensembl chr 1:166,899,894...166,912,524
JBrowse link
G Insr insulin receptor IEP RGD PMID:29896241, PMID:25352008 RGD:14700925, RGD:14700927 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Kpna1 karyopherin subunit alpha 1 ISO PID PID:200197 NCBI chr11:67,652,573...67,717,180
Ensembl chr11:67,652,577...67,703,025
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200197 NCBI chr 1:15,412,603...15,613,752
Ensembl chr 1:15,412,603...15,613,746
JBrowse link
G Mapkap1 MAPK associated protein 1 ISO PID PID:200197 NCBI chr 3:13,484,952...13,701,772
Ensembl chr 3:13,484,838...13,701,757
JBrowse link
G Mlst8 MTOR associated protein, LST8 homolog ISO PID PID:200197 NCBI chr10:13,839,250...13,845,001
Ensembl chr10:13,839,250...13,845,001
JBrowse link
G Mtor mechanistic target of rapamycin kinase ISO PID PID:200197 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PMID:17641274 PID:200197, RGD:2290458 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 ISO RGD PMID:24794538 RGD:11535053 NCBI chr13:26,145,989...26,394,505
Ensembl chr13:26,172,243...26,394,505
JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 ISO RGD PMID:24794538 RGD:11535053 NCBI chr19:41,731,845...41,798,451
Ensembl chr19:41,731,646...41,798,383
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:17641274 RGD:2290458 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta ISO RGD PMID:17641274 RGD:2290458 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta ISO RGD PMID:17641274 RGD:2290458 NCBI chr 5:166,602,053...166,628,028
Ensembl chr 5:166,602,053...166,628,028
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO
IMP
RGD PMID:29666415, PMID:29323718, PMID:21665152 RGD:38599151, RGD:38599216, RGD:38599159 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO RGD PMID:17641274 RGD:2290458 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO RGD PMID:17641274 RGD:2290458 NCBI chr16:20,415,109...20,424,982
Ensembl chr16:20,416,432...20,424,980
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO RGD PMID:17641274 RGD:2290458 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha ISO RGD PMID:23454242 RGD:11535052 NCBI chr10:37,534,449...37,554,861
Ensembl chr10:37,535,871...37,554,664
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta ISO RGD PMID:23454242 RGD:11535052 NCBI chr16:62,273,276...62,294,767
Ensembl chr16:62,273,276...62,294,769
JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha ISO RGD PMID:23454242 RGD:11535052 NCBI chr 1:60,717,386...60,736,629
Ensembl chr 1:60,717,386...60,736,609
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta ISO RGD PMID:23454242 RGD:11535052 NCBI chr 8:55,279,278...55,311,768
Ensembl chr 8:55,279,373...55,301,320
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha ISO RGD PMID:23454242 RGD:11535052 NCBI chr15:43,673,958...43,733,182
Ensembl chr15:43,673,960...43,733,182
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO PID PID:200197 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO PID PID:200197 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:17641274 RGD:2290458 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO PID PID:200197 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 ISO PID PID:200197 NCBI chr 2:56,013,898...56,105,818
Ensembl chr 2:56,052,643...56,101,803
JBrowse link
G Sfn stratifin ISO PID PID:200197 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Slc2a4 solute carrier family 2 member 4 ISO PID PID:200197 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200197 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 ISO PID PID:200197 NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta ISO PID PID:200197 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon ISO PID PID:200197 NCBI chr10:63,884,338...63,921,709
Ensembl chr10:63,884,338...63,921,709
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma ISO PID PID:200197 NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta ISO PID PID:200197 NCBI chr14:83,053,041...83,062,424
Ensembl chr14:83,053,041...83,062,424
JBrowse link
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta ISO PID PID:200197 NCBI chr 6:43,463,294...43,493,816
Ensembl chr 6:43,463,294...43,493,816
JBrowse link
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta ISO PID PID:200197 NCBI chr 7:75,573,553...75,598,295
Ensembl chr 7:75,574,967...75,597,276
JBrowse link
protein kinase A (PKA) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 ISO RGD PMID:18948702 RGD:2312469 NCBI chr14:87,311,970...87,429,880
Ensembl chr14:87,312,203...87,421,659
JBrowse link
G Adcy10 adenylate cyclase 10 ISO RGD PMID:18948702 RGD:2312469 NCBI chr13:83,701,952...83,787,010
Ensembl chr13:83,721,300...83,787,018
JBrowse link
G Adcy2 adenylate cyclase 2 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 1:37,043,071...37,698,390
Ensembl chr 1:37,507,276...37,698,390
JBrowse link
G Adcy3 adenylate cyclase 3 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 6:28,570,941...28,648,848
Ensembl chr 6:28,571,351...28,650,148
JBrowse link
G Adcy4 adenylate cyclase 4 ISO RGD PMID:18948702 RGD:2312469 NCBI chr15:34,453,917...34,469,779
Ensembl chr15:34,453,915...34,469,746
JBrowse link
G Adcy5 adenylate cyclase 5 ISO RGD PMID:18948702 RGD:2312469 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy6 adenylate cyclase 6 ISO
IDA
RGD PMID:18948702, PMID:15579502 RGD:2312469, RGD:2313211 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcy7 adenylate cyclase 7 ISO RGD PMID:18948702 RGD:2312469 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Adcy8 adenylate cyclase 8 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Adcy9 adenylate cyclase 9 ISO RGD PMID:18948702 RGD:2312469 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Akap1 A-kinase anchoring protein 1 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr10:76,151,013...76,183,987
Ensembl chr10:76,151,038...76,166,276
JBrowse link
G Akap10 A-kinase anchoring protein 10 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr10:48,150,902...48,210,074
Ensembl chr10:48,150,902...48,210,074
JBrowse link
G Akap11 A-kinase anchoring protein 11 ISO
IMP
RGD PMID:14715913, PMID:18385542, PMID:19319965 RGD:2312475, RGD:2312637, RGD:2312477 NCBI chr15:60,722,138...60,766,673
Ensembl chr15:60,722,160...60,766,579
JBrowse link
G Akap12 A-kinase anchoring protein 12 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581
JBrowse link
G Akap13 A-kinase anchoring protein 13 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 1:137,089,558...137,315,272
Ensembl chr 1:137,014,272...137,315,272
JBrowse link
G Akap14 A-kinase anchoring protein 14 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:123,773,430...123,788,898
Ensembl chr  X:123,773,430...123,788,898
JBrowse link
G Akap2 A-kinase anchoring protein 2 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 5:74,874,245...74,985,789
Ensembl chr 5:74,874,306...74,982,401
JBrowse link
G Akap3 A-kinase anchoring protein 3 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 4:159,399,686...159,425,512
Ensembl chr 4:159,403,501...159,425,629
JBrowse link
G Akap4 A-kinase anchoring protein 4 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr  X:16,296,027...16,306,078
Ensembl chr  X:16,296,735...16,306,078
JBrowse link
G Akap5 A-kinase anchoring protein 5 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 6:99,356,509...99,361,909
Ensembl chr 6:99,356,509...99,361,909
JBrowse link
G Akap6 A-kinase anchoring protein 6 ISO
IMP
RGD PMID:14715913, PMID:11296225, PMID:19319965 RGD:2312475, RGD:68716, RGD:2312477 NCBI chr 6:73,553,111...73,991,992
Ensembl chr 6:73,553,210...73,990,534
JBrowse link
G Akap7 A-kinase anchoring protein 7 ISO
IMP
RGD PMID:14715913, PMID:17901878, PMID:19319965 RGD:2312475, RGD:2312630, RGD:2312477 NCBI chr 1:21,129,213...21,263,850
Ensembl chr 1:21,141,970...21,263,850
JBrowse link
G Akap8 A-kinase anchoring protein 8 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 7:14,323,298...14,339,953
Ensembl chr 7:14,324,104...14,351,918
JBrowse link
G Akap9 A-kinase anchoring protein 9 ISO RGD PMID:14715913, PMID:19319965 RGD:2312475, RGD:2312477 NCBI chr 4:27,195,346...27,331,582
Ensembl chr 4:27,195,346...27,331,582
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:15911134 RGD:5131271 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Ezr ezrin ISO RGD PMID:14715913 RGD:2312475 NCBI chr 1:47,287,872...47,331,412
Ensembl chr 1:47,287,874...47,331,412
JBrowse link
G Pde10a phosphodiesterase 10A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde11a phosphodiesterase 11A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 3:62,818,502...63,211,843
Ensembl chr 3:62,818,502...63,211,845
JBrowse link
G Pde1a phosphodiesterase 1A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094
JBrowse link
G Pde1b phosphodiesterase 1B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 7:145,117,951...145,147,711
Ensembl chr 7:145,117,951...145,145,376
JBrowse link
G Pde1c phosphodiesterase 1C ISO RGD PMID:17376027 RGD:2312479 NCBI chr 4:86,359,762...86,925,044
Ensembl chr 4:86,359,820...86,630,543
JBrowse link
G Pde2a phosphodiesterase 2A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pde3a phosphodiesterase 3A ISO RGD PMID:17376027, PMID:17376027 RGD:2312479, RGD:2312479 NCBI chr 4:175,431,904...175,703,844
Ensembl chr 4:175,431,904...175,700,238
JBrowse link
G Pde3b phosphodiesterase 3B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:183,892,841...184,078,071
Ensembl chr 1:183,892,841...184,078,071
JBrowse link
G Pde4a phosphodiesterase 4A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4c phosphodiesterase 4C ISO RGD PMID:17376027 RGD:2312479 NCBI chr16:20,442,305...20,466,386
Ensembl chr16:20,442,609...20,460,959
Ensembl chr16:20,442,609...20,460,959
JBrowse link
G Pde4d phosphodiesterase 4D ISO
IMP
RGD PMID:17376027, PMID:11296225 RGD:2312479, RGD:68716 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde7a phosphodiesterase 7A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde7b phosphodiesterase 7B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:15,889,845...16,203,909
Ensembl chr 1:15,893,533...16,203,909
JBrowse link
G Pde8a phosphodiesterase 8A ISO RGD PMID:17376027 RGD:2312479 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pde8b phosphodiesterase 8B ISO RGD PMID:17376027 RGD:2312479 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr 2:252,602,197...252,691,886
Ensembl chr 2:252,605,307...252,691,886
JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr10:97,940,705...97,959,199
Ensembl chr10:97,940,705...97,957,336
JBrowse link
G Prkar1b protein kinase cAMP-dependent type I regulatory subunit beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr12:17,614,536...17,713,567
Ensembl chr12:17,614,632...17,712,373
JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha ISO RGD PMID:14715913 RGD:2312475 NCBI chr 8:117,486,085...117,548,768
Ensembl chr 8:117,486,083...117,546,370
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta ISO RGD PMID:14715913 RGD:2312475 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383
JBrowse link
protein kinase C (PKC) signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btk Bruton tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr  X:105,360,922...105,390,580
Ensembl chr  X:105,360,922...105,390,580
JBrowse link
G Cdc37 cell division cycle 37, HSP90 cochaperone ISO RGD PMID:19934406 RGD:5131489 NCBI chr 8:22,160,922...22,173,797
Ensembl chr 8:22,154,067...22,173,804
JBrowse link
G Copb1 COPI coat complex subunit beta 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr 1:183,695,480...183,729,569
Ensembl chr 1:183,695,481...183,729,569
JBrowse link
G Fscn1 fascin actin-bundling protein 1 ISO RGD PMID:15380937 RGD:5131492 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:19934406 RGD:5131489 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase ISO RGD PMID:15380937 RGD:5131492 NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
JBrowse link
G Ldb3 LIM domain binding 3 ISO RGD PMID:18491053, PMID:15380937 RGD:5131491, RGD:5131492 NCBI chr16:10,878,348...10,943,016
Ensembl chr16:10,878,334...10,941,501
JBrowse link
G Pard3 par-3 family cell polarity regulator ISO RGD PMID:16525119 RGD:5132275 NCBI chr19:60,017,746...60,580,628
Ensembl chr19:60,017,746...60,580,651
JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO RGD PMID:16525119 RGD:5132275 NCBI chr19:37,668,133...37,670,450
Ensembl chr19:37,668,133...37,672,729
JBrowse link
G Pard6b par-6 family cell polarity regulator beta ISO RGD PMID:16525119 RGD:5132275 NCBI chr 3:164,822,111...164,843,395
Ensembl chr 3:164,822,111...164,843,395
JBrowse link
G Pard6g par-6 family cell polarity regulator gamma ISO RGD PMID:16525119 RGD:5132275 NCBI chr18:76,559,877...76,627,843
Ensembl chr18:76,559,811...76,628,041
JBrowse link
G Pcnt pericentrin ISO RGD PMID:15380937 RGD:5131492 NCBI chr20:12,943,523...13,038,615
Ensembl chr20:12,944,786...13,038,431
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO RGD PMID:19934406 RGD:5131489 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 IMP
ISO
RGD PMID:20819118, PMID:18511290 RGD:8693633, RGD:5131497 NCBI chr13:26,145,989...26,394,505
Ensembl chr13:26,172,243...26,394,505
JBrowse link
G Phlpp2 PH domain and leucine rich repeat protein phosphatase 2 ISO RGD PMID:18511290 RGD:5131497 NCBI chr19:41,731,845...41,798,451
Ensembl chr19:41,731,646...41,798,383
JBrowse link
G Pick1 protein interacting with PRKCA 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
G Plcb1 phospholipase C beta 1 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb2 phospholipase C, beta 2 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Plcb3 phospholipase C beta 3 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcb4 phospholipase C, beta 4 ISO RGD PMID:17524618 RGD:5131502 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Prkca protein kinase C, alpha ISO RGD PMID:19934406 RGD:5131489 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta ISO RGD PMID:19934406 RGD:5131489 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prkcd protein kinase C, delta ISO RGD PMID:19934406 RGD:5131489 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Prkce protein kinase C, epsilon ISO RGD PMID:19934406 RGD:5131489 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prkcg protein kinase C, gamma ISO RGD PMID:19934406 RGD:5131489 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636
JBrowse link
G Prkch protein kinase C, eta ISO
IMP
RGD PMID:19934406, PMID:9677361 RGD:5131489, RGD:5131657 NCBI chr 6:96,479,243...96,677,368
Ensembl chr 6:96,479,430...96,676,225
JBrowse link
G Prkci protein kinase C, iota ISO RGD PMID:19934406, PMID:16525119 RGD:5131489, RGD:5132275 NCBI chr 2:115,941,998...116,002,550
Ensembl chr 2:115,941,993...116,002,561
JBrowse link
G Prkcq protein kinase C, theta ISO RGD PMID:19934406 RGD:5131489 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Prkcz protein kinase C, zeta ISO
IMP
RGD PMID:19934406, PMID:16525119, PMID:20570724 RGD:5131489, RGD:5132275, RGD:5131661 NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
JBrowse link
G Rack1 receptor for activated C kinase 1 ISO RGD PMID:18491053 RGD:5131491 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link
G Rasa1 RAS p21 protein activator 1 IMP RGD PMID:7588705 RGD:10002727 NCBI chr 2:13,617,021...13,696,531
Ensembl chr 2:13,616,822...13,696,426
JBrowse link
sphingosine 1-phosphate signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 ISO PID PID:200085, PID:200123 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200046 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO PID PID:200046 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Cdc42 cell division cycle 42 ISO PID PID:200054 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdh5 cadherin 5 ISO PID PID:200211 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 ISO PID PID:200046 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Elk1 ETS transcription factor ELK1 ISO PID PID:200211 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 ISO PID PID:200046 NCBI chr12:9,033,993...9,205,886
Ensembl chr12:9,034,308...9,205,905
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200211 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gna11 G protein subunit alpha 11 ISO PID PID:200046, PID:200123, PID:200211 NCBI chr 7:11,033,400...11,047,284
Ensembl chr 7:11,033,317...11,047,437
JBrowse link
G Gna12 G protein subunit alpha 12 ISO PID PID:200046, PID:200054, PID:200076, PID:200123, PID:200211 NCBI chr12:15,890,202...15,971,212
Ensembl chr12:15,890,170...15,971,212
JBrowse link
G Gna13 G protein subunit alpha 13 ISO PID PID:200046, PID:200054, PID:200123, PID:200211 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gna14 G protein subunit alpha 14 ISO PID PID:200046, PID:200123, PID:200211 NCBI chr 1:235,165,775...235,347,986
Ensembl chr 1:235,166,718...235,347,937
JBrowse link
G Gna15 G protein subunit alpha 15 ISO PID PID:200046, PID:200123, PID:200211 NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251
JBrowse link
G Gnai1 G protein subunit alpha i1 ISO PID PID:200046, PID:200054, PID:200076, PID:200085, PID:200123, PID:200211 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO PID PID:200046, PID:200054, PID:200076, PID:200085, PID:200123, PID:200211 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 ISO PID PID:200046, PID:200054, PID:200076, PID:200085, PID:200123, PID:200211 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gnao1 G protein subunit alpha o1 ISO PID PID:200046, PID:200054, PID:200076, PID:200085, PID:200123, PID:200211 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Gnaq G protein subunit alpha q ISO PID PID:200046, PID:200123, PID:200211 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Gnaz G protein subunit alpha z ISO PID PID:200046, PID:200054, PID:200076, PID:200085, PID:200123, PID:200211 NCBI chr20:14,593,072...14,644,020
Ensembl chr20:14,593,819...14,620,019
JBrowse link
G Irs1 insulin receptor substrate 1 ISO PID PID:200211 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Itgav integrin subunit alpha V ISO PID PID:200046, PID:200085 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgb3 integrin subunit beta 3 ISO PID PID:200046, PID:200085 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jak2 Janus kinase 2 ISO PID PID:200046 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200211 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdr kinase insert domain receptor ISO PID PID:200085 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200046, PID:200054, PID:200085, PID:200211 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 ISO PID PID:200211 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200046, PID:200054, PID:200085, PID:200211 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200211 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO PID PID:200211 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Pdgfb platelet derived growth factor subunit B ISO PID PID:200046, PID:200085 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta ISO PID PID:200046, PID:200085 NCBI chr18:56,364,586...56,406,381
Ensembl chr18:56,364,620...56,406,381
JBrowse link
G Plcb2 phospholipase C, beta 2 ISO PID PID:200085 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO PID PID:200054, PID:200085 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO PID PID:200085 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200046, PID:200085, PID:200211 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rhoa ras homolog family member A ISO PID PID:200046, PID:200054, PID:200076, PID:200085, PID:200211 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 ISO PID PID:200046, PID:200085, PID:200123 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 ISO PID PID:200046, PID:200123, PID:200211 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 ISO PID PID:200046, PID:200123 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G S1pr4 sphingosine-1-phosphate receptor 4 ISO PID PID:200054, PID:200123 NCBI chr 7:11,077,411...11,079,687
Ensembl chr 7:11,077,411...11,079,687
JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 ISO PID PID:200054, PID:200076, PID:200123 NCBI chr 8:22,268,635...22,273,708
Ensembl chr 8:22,268,657...22,270,647
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 ISO PID PID:200123 NCBI chr20:30,699,936...30,769,178
Ensembl chr20:30,699,872...30,749,940
JBrowse link
G Sgpp1 sphingosine-1-phosphate phosphatase 1 ISO PID PID:200123 NCBI chr 6:98,675,324...98,696,492
Ensembl chr 6:98,675,326...98,695,988
JBrowse link
G Sphk1 sphingosine kinase 1 ISO PID PID:200085, PID:200123 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Sphk2 sphingosine kinase 2 ISO PID PID:200123 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200046 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vegfa vascular endothelial growth factor A ISO PID PID:200046, PID:200085 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.