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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:cholesterol biosynthetic pathway
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Accession:PW:0000454 term browser browse the term
Definition:Those metabolic reactions involved in the synthesis of cholesterol, an essential sterol component of mammalian cell membrane. Cholesterol is the precursor of all steroid hormones.
Synonyms:related_synonym: Cholesterol biosynthesis;   cholesterol biosynthetic process
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cholesterol biosynthetic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:50,100,817...50,135,095 		JBrowse link
G Cyp51 cytochrome P450, family 51 ISO
IDA 		SMPDB
RGD		 PMID:16876788 PMID:12668600 PMID:7581240 SMP:00023, RGD:2316857, RGD:2316868, RGD:2316902 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,991,613...31,010,450 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase ISO SMPDB
RGD		 PMID:16876788 PMID:12668600 SMP:00023, RGD:2316857, RGD:2316868 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936 		JBrowse link
G Dhcr7 7-dehydrocholesterol reductase ISO
IMP 		RGD PMID:16876788 PMID:12668600 PMID:9831636 RGD:2316857, RGD:2316868, RGD:2316918 NCBI chr 1:208,444,434...208,460,408
Ensembl chr 1:208,444,434...208,461,382 		JBrowse link
G Ebp EBP, cholestenol delta-isomerase ISO SMPDB
RGD		 PMID:16876788 PMID:12668600 SMP:00023, RGD:2316857, RGD:2316868 NCBI chr  X:16,971,372...16,977,782
Ensembl chr  X:16,971,405...16,977,781 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 IMP
ISO 		SMPDB
RGD		 PMID:16440058 PMID:16876788 SMP:00023, RGD:1626611, RGD:2316857 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fdps farnesyl diphosphate synthase ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 ISO SMPDB SMP:00023 NCBI chr17:55,958,750...55,982,762
Ensembl chr17:55,958,755...55,971,709 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 ISO SMPDB SMP:00023 NCBI chr13:84,702,875...84,722,810
Ensembl chr13:84,705,631...84,722,754 		JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524 		JBrowse link
G Lbr lamin B receptor ISO RGD PMID:16876788 PMID:12668600 RGD:2316857, RGD:2316868 NCBI chr13:96,071,058...96,095,709
Ensembl chr13:96,071,081...96,095,709 		JBrowse link
G Lipa lipase A, lysosomal acid type ISO SMPDB SMP:00023 NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:241,437,524...241,470,740 		JBrowse link
G Lss lanosterol synthase IMP
ISO
IDA 		SMPDB
RGD		 PMID:16440058 PMID:16876788 PMID:1429550 SMP:00023, RGD:1626611, RGD:2316857, RGD:2316919 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 ISO SMPDB SMP:00023 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mvd mevalonate diphosphate decarboxylase ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr19:67,404,911...67,414,974
Ensembl chr19:67,404,911...67,422,366 		JBrowse link
G Mvk mevalonate kinase ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503 		JBrowse link
G Nsdhl NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL ISO SMPDB
RGD		 PMID:16876788 PMID:12668600 SMP:00023, RGD:2316857, RGD:2316868 NCBI chr  X:155,817,301...155,848,224
Ensembl chr  X:155,817,340...155,848,220 		JBrowse link
G Pmvk phosphomevalonate kinase ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr 2:177,174,344...177,184,076
Ensembl chr 2:177,174,335...177,184,080 		JBrowse link
G Sc5d sterol-C5-desaturase ISO
IDA 		SMPDB
RGD		 PMID:16876788 PMID:12668600 PMID:7961720 SMP:00023, RGD:2316857, RGD:2316868, RGD:2316911 NCBI chr 8:51,526,669...51,538,277
Ensembl chr 8:51,529,346...51,538,277 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ISO SMPDB SMP:00023 NCBI chr13:71,105,178...71,147,776
Ensembl chr13:71,105,178...71,147,672 		JBrowse link
G Sqle squalene epoxidase ISO SMPDB
RGD		 PMID:16876788 SMP:00023, RGD:2316857 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 ISO SMPDB SMP:00023 NCBI chr 1:212,785,217...212,789,572
Ensembl chr 1:212,785,217...212,789,557 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1852
      lipid metabolic pathway 488
        isoprenoid metabolic pathway 95
          isoprenoid biosynthetic pathway 82
            steroid biosynthetic pathway 82
              cholesterol biosynthetic pathway 24
                altered cholesterol biosynthetic pathway 0
paths to the root