PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: altered mitogen activated protein kinase pathway
Accession: PW:0000421
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Definition: A mitogen activated protein kinase pathway that deviates from what its normal course should be. Altered MAPK pathways have been linked to a spectrum of conditions.
Synonyms: related_synonym: altered MAPK signaling pathway
G
Map2k5
mitogen activated protein kinase kinase 5
ISO
RGD
PMID:16376520
RGD:2298532
NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
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Mapk7
mitogen-activated protein kinase 7
ISO
RGD
PMID:16376520
RGD:2298532
NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055
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Braf
B-Raf proto-oncogene, serine/threonine kinase
ISO
RGD
PMID:17126425 , PMID:21277552 , PMID:20951313 , PMID:18098337
RGD:2293882 , RGD:5133243 , RGD:5133242 , RGD:2298531
NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
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Kras
KRAS proto-oncogene, GTPase
TAS ISO
RGD
PMID:16112461 , PMID:18772397 , PMID:19506583 , PMID:20951313 , PMID:19078924
RGD:2306732 , RGD:5490966 , RGD:5490965 , RGD:5133242 , RGD:4143515
NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
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Map2k1
mitogen activated protein kinase kinase 1
ISO
RGD
PMID:20951313 , PMID:21277552
RGD:5133242 , RGD:5133243
NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
ISO
RGD
PMID:17126425
RGD:2293882
NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
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