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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered mitogen activated protein kinase pathway
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Accession:PW:0000421 term browser browse the term
Definition:A mitogen activated protein kinase pathway that deviates from what its normal course should be. Altered MAPK pathways have been linked to a spectrum of conditions.
Synonyms:related_synonym: altered MAPK signaling pathway

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altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590 		JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055 		JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425, PMID:21277552, PMID:20951313, PMID:18098337 RGD:2293882, RGD:5133243, RGD:5133242, RGD:2298531 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356 		JBrowse link
G Kras KRAS proto-oncogene, GTPase TAS
ISO		 RGD PMID:16112461, PMID:18772397, PMID:19506583, PMID:20951313, PMID:19078924 RGD:2306732, RGD:5490966, RGD:5490965, RGD:5133242, RGD:4143515 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO RGD PMID:20951313, PMID:21277552 RGD:5133242, RGD:5133243 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6106
    signaling pathway 2647
      mitogen activated protein kinase signaling pathway 300
        altered mitogen activated protein kinase pathway 6
          altered Erk5 MAPK signaling pathway 2
          altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
          altered stress-regulated MAPK signaling pathway + 0
Path 2
Term Annotations click to browse term
  pathway 6106
    signaling pathway 2647
      altered signaling pathway 116
        altered kinase mediated signaling pathway 13
          altered serine/threonine-specific kinase mediated signaling pathway 11
            altered mitogen activated protein kinase pathway 6
              altered Erk5 MAPK signaling pathway 2
              altered extracellular signal-regulated Raf/Mek/Erk signaling pathway 4
              altered stress-regulated MAPK signaling pathway + 0
paths to the root