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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:Reelin signaling pathway
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Accession:PW:0000388 term browser browse the term
Definition:The reelin signaling pathway regulates neuronal positioning and may also play a role in synaptic plasticity. The reelin gene appears to be downregulated in schizophrenic brains but the link between the reelin pathway and the disease remains to be established.
Synonyms:related_synonym: PID:200062

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Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200062 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 ISO PID PID:200062 NCBI chr 2:187,964,100...188,022,847
Ensembl chr 2:187,977,008...188,021,377
JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200062 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cdk5 cyclin-dependent kinase 5 ISO PID PID:200062 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 ISO PID PID:200062 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein ISO PID PID:200062 NCBI chr11:87,338,606...87,356,644
Ensembl chr11:87,778,312...87,815,043
JBrowse link
G Dab1 DAB adaptor protein 1 TAS
ISO
PID PMID:12670697 PID:200062, RGD:727518 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO PID PMID:12778121 PID:200062, RGD:2324970 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 TAS RGD PMID:18237558 RGD:2325284 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A TAS
ISO
PID PMID:18237558 PID:200062, RGD:2325284 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B TAS
ISO
PID PMID:18237558 PID:200062, RGD:2325284 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO PID PID:200062 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 ISO PID PMID:15583703 PID:200062, RGD:2325851 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Lrp8 LDL receptor related protein 8 ISO PID PMID:19846452 PID:200062, RGD:2324974 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641
JBrowse link
G Lrpap1 LDL receptor related protein associated protein 1 ISO PID PID:200062 NCBI chr14:80,911,281...80,923,290
Ensembl chr14:80,911,270...80,924,831
JBrowse link
G Map1b microtubule-associated protein 1B ISO PID PID:200062 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 ISO PID PID:200062 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 ISO PID PID:200062 NCBI chr 1:221,043,119...221,056,420
Ensembl chr 1:221,043,119...221,056,417
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200062 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapt microtubule-associated protein tau ISO PID PID:200062 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200062 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO PID PMID:17330141 PID:200062, RGD:4107040 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:82,163,733...82,166,259
Ensembl chr 1:82,163,595...82,166,363
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200062 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PMID:17167084 PID:200062, RGD:4108507 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family ISO PID PID:200062 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO PID PID:200062 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G Reln reelin TAS
ISO
PID PMID:12670697 PID:200062, RGD:727518 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vldlr very low density lipoprotein receptor TAS
ISO
PID PMID:12670697 PID:200062, RGD:727518 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab1 DAB adaptor protein 1 TAS RGD PMID:12670697 RGD:727518 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Lrp8 LDL receptor related protein 8 ISO RGD PMID:19846452 RGD:2324974 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:82,163,733...82,166,259
Ensembl chr 1:82,163,595...82,166,363
JBrowse link
G Reln reelin TAS RGD PMID:12670697 RGD:727518 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vldlr very low density lipoprotein receptor ISS RGD PMID:12764038 RGD:1358468 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6103
    signaling pathway 2646
      signaling pathway pertinent to the brain and nervous system 464
        Reelin signaling pathway 32
          altered Reelin signaling pathway 11
Path 2
Term Annotations click to browse term
  pathway 6103
    signaling pathway 2646
      glycoconjugated protein signaling pathway 414
        glycoprotein signaling pathway 299
          Reelin signaling pathway 32
            altered Reelin signaling pathway 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.