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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:nuclear factor, erythroid 2 like 2 signaling pathway
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Accession:PW:0000369 term browser browse the term
Definition:Nuclear factor, 2 like 2 (Nfe2l2, also known as Nrf2) signaling pathway is one of the most important regulator of antioxidant and/or electrophilic stress responses. Upon activation, Nfe2l2 induces the expression of antioxidant, xenobiotic metabolism, and cytoprotective genes, among others. Deregulation of the pathway has been associated with various conditions, including neurodegeneration and cancer.
Synonyms:exact_synonym: Nrf2 signaling pathway
 related_synonym: Nfe2l2 signaling pathway
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nuclear factor, erythroid 2 like 2 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRCA1 BRCA1 DNA repair associated TAS RGD PMID:24647116 RGD:11535066 NCBI chr17:43,044,295...43,170,327
Ensembl chr17:43,044,295...43,170,245 		JBrowse link
G BTRC beta-transducin repeat containing E3 ubiquitin protein ligase TAS RGD PMID:24647116 PMID:25937177 RGD:11535066, RGD:11535070 NCBI chr10:101,354,048...101,557,313
Ensembl chr10:101,354,033...101,557,321 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A TAS RGD PMID:24647116 RGD:11535066 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,397 		JBrowse link
G CHD6 chromodomain helicase DNA binding protein 6 TAS RGD PMID:24647116 RGD:11535066 NCBI chr20:41,402,083...41,618,377
Ensembl chr20:41,402,083...41,618,384 		JBrowse link
G CREBBP CREB binding protein TAS RGD PMID:24647116 RGD:11535066 NCBI chr16:3,725,054...3,880,713
Ensembl chr16:3,725,054...3,880,713 		JBrowse link
G CUL1 cullin 1 TAS RGD PMID:24647116 RGD:11535066 NCBI chr 7:148,697,756...148,801,110
Ensembl chr 7:148,697,914...148,801,110 		JBrowse link
G CUL3 cullin 3 TAS RGD PMID:24647116 RGD:11535066 NCBI chr 2:224,470,150...224,585,363
Ensembl chr 2:224,470,150...224,585,397 		JBrowse link
G DPP3 dipeptidyl peptidase 3 TAS RGD PMID:24647116 RGD:11535066 NCBI chr11:66,480,434...66,509,657
Ensembl chr11:66,480,013...66,509,657 		JBrowse link
G GADD45GIP1 GADD45G interacting protein 1 TAS RGD PMID:24647116 RGD:11535066 NCBI chr19:12,953,119...12,957,223
Ensembl chr19:12,953,119...12,957,223 		JBrowse link
G GSK3A glycogen synthase kinase 3 alpha TAS RGD PMID:25937177 RGD:11535070 NCBI chr19:42,230,190...42,242,602
Ensembl chr19:42,226,225...42,242,625 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta TAS RGD PMID:25937177 RGD:11535070 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta TAS RGD PMID:24647116 RGD:11535066 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 TAS
ISO 		RGD PMID:26419687 PMID:20026152 PMID:24647116 RGD:11530066, RGD:6902900, RGD:11535066 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G MAFF MAF bZIP transcription factor F TAS RGD PMID:24647116 RGD:11535066 NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,511 		JBrowse link
G MAFG MAF bZIP transcription factor G TAS RGD PMID:24647116 RGD:11535066 NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735 		JBrowse link
G MAFK MAF bZIP transcription factor K TAS RGD PMID:24647116 RGD:11535066 NCBI chr 7:1,530,702...1,543,043
Ensembl chr 7:1,530,702...1,543,043 		JBrowse link
G NCOA3 nuclear receptor coactivator 3 TAS RGD PMID:24647116 RGD:11535066 NCBI chr20:47,501,887...47,656,872
Ensembl chr20:47,501,887...47,656,877 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 TAS RGD PMID:26419687 PMID:25937177 PMID:24647116 RGD:11530066, RGD:11535070, RGD:11535066 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 ISO RGD PMID:31889292 PMID:31432116 RGD:21201308, RGD:25823187 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PALB2 partner and localizer of BRCA2 TAS RGD PMID:24647116 RGD:11535066 NCBI chr16:23,603,165...23,641,310
Ensembl chr16:23,603,160...23,641,321 		JBrowse link
G PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase TAS RGD PMID:24647116 RGD:11535066 NCBI chr12:132,710,842...132,722,734
Ensembl chr12:132,710,819...132,722,734 		JBrowse link
G PTEN phosphatase and tensin homolog TAS RGD PMID:25937177 RGD:11535070 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G RBX1 ring-box 1 TAS RGD PMID:24647116 RGD:11535066 NCBI chr22:40,951,378...40,973,309
Ensembl chr22:40,951,347...40,973,309 		JBrowse link
G RNF4 ring finger protein 4 TAS RGD PMID:24647116 RGD:11535066 NCBI chr 4:2,469,106...2,515,857
Ensembl chr 4:2,462,220...2,515,857 		JBrowse link
G SIAH2 siah E3 ubiquitin protein ligase 2 TAS RGD PMID:24647116 RGD:11535066 NCBI chr 3:150,741,125...150,763,169
Ensembl chr 3:150,741,125...150,763,477 		JBrowse link
G SKP1 S-phase kinase associated protein 1 TAS RGD PMID:24647116 RGD:11535066 NCBI chr 5:134,148,935...134,176,950
Ensembl chr 5:134,148,935...134,176,964 		JBrowse link
G SQSTM1 sequestosome 1 TAS RGD PMID:24647116 RGD:11535066 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    regulatory pathway 3600
      cellular detoxification pathway 81
        nuclear factor, erythroid 2 like 2 signaling pathway 27
          altered nuclear factor, erythroid 2 like 2 signaling pathway 0
Path 2
Term Annotations click to browse term
  pathway 5957
    regulatory pathway 3600
      pathway pertinent to DNA replication and repair, cell cycle, maintenance of genomic integrity, RNA and protein biosynthesis 1637
        transcription pathway 1053
          transcription pathway via transcription factor mediated signaling 448
            nuclear factor, erythroid 2 like 2 signaling pathway 27
              altered nuclear factor, erythroid 2 like 2 signaling pathway 0
paths to the root