PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: fibroblast growth factor signaling pathway
Accession: PW:0000328
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Definition: The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and it relies on the Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
Synonyms: related_synonym: FGF signaling pathway; Signaling by FGFR; fibroblast growth factor receptor signaling pathway
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AKT1
AKT serine/threonine kinase 1
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PID
PID:200220
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CAMK2A
calcium/calmodulin dependent protein kinase II alpha
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PID
PID:200220
NCBI chr 2:151,248,356...151,353,907
Ensembl chr 2:151,248,358...151,308,706
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CBL
Cbl proto-oncogene
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PID
PID:200220
NCBI chr 9:46,416,937...46,512,855
Ensembl chr 9:46,416,938...46,512,834
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CDH1
cadherin 1
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PID
PID:200220
NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986
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CDH2
cadherin 2
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PID
PID:200220
NCBI chr 6:112,396,713...112,629,073
Ensembl chr 6:112,396,721...112,628,432
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CTNND1
catenin delta 1
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PID
PID:200220
NCBI chr 2:13,143,604...13,209,251
Ensembl chr 2:13,154,338...13,209,250
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CTTN
cortactin
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PID
PID:200220
NCBI chr 2:3,031,103...3,060,796
Ensembl chr 2:3,031,103...3,060,813
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FGF1
fibroblast growth factor 1
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PID
PID:200220
NCBI chr 2:144,133,846...144,241,345
Ensembl chr 2:144,133,392...144,241,323
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FGF17
fibroblast growth factor 17
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PID
PID:200220
NCBI chr14:6,310,840...6,315,465
Ensembl chr14:6,309,735...6,315,882
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FGF18
fibroblast growth factor 18
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PID
PID:200220
NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791
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FGF19
fibroblast growth factor 19
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PID
PID:200220
NCBI chr 2:3,583,027...3,586,985
Ensembl chr 2:3,582,828...3,587,752
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FGF2
fibroblast growth factor 2
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PID
PID:200220
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
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FGF23
fibroblast growth factor 23
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PID
PID:200220
NCBI chr 5:66,028,591...66,038,078
Ensembl chr 5:66,028,776...66,038,740
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FGF4
fibroblast growth factor 4
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PID
PID:200220
NCBI chr 2:3,527,113...3,529,011
Ensembl chr 2:3,526,914...3,529,874
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FGF6
fibroblast growth factor 6
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PID
PID:200220
NCBI chr 5:65,975,807...65,990,035
Ensembl chr 5:65,975,838...65,990,029
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FGF8
fibroblast growth factor 8
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PID
PID:200220
NCBI chr14:112,808,215...112,814,225
Ensembl chr14:112,808,162...112,814,248
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FGF9
fibroblast growth factor 9
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RGD PID
PMID:15231666
PID:200220 RGD:1304345
NCBI chr11:1,554,648...1,581,938
Ensembl chr11:1,554,763...1,582,408
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FGFR1
fibroblast growth factor receptor 1
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PID
PID:200220
NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724
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FGFR2
fibroblast growth factor receptor 2
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RGD PID
PMID:15292181
PID:200220 RGD:2289848
NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425
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FGFR3
fibroblast growth factor receptor 3
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RGD
PMID:15231666
RGD:1304345
NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964
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FGFR4
fibroblast growth factor receptor 4
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PID
PID:200220
NCBI chr 2:80,841,536...80,853,791
Ensembl chr 2:80,841,536...80,853,796
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FOS
Fos proto-oncogene, AP-1 transcription factor subunit
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PID
PID:200220
NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
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FRS2
fibroblast growth factor receptor substrate 2
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PID
PID:200220
NCBI chr 5:33,725,432...33,852,952
Ensembl chr 5:33,725,444...33,849,953
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GAB1
GRB2 associated binding protein 1
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PID
PID:200220
NCBI chr 8:84,257,958...84,391,511
Ensembl chr 8:84,257,965...84,391,914
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GRB2
growth factor receptor bound protein 2
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PID
PID:200220
NCBI chr12:5,940,723...6,009,095
Ensembl chr12:5,940,647...6,010,835
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HGF
hepatocyte growth factor
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PID
PID:200220
NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564
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IL17RD
interleukin 17 receptor D
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PID
PID:200220
NCBI chr13:38,935,631...39,006,721
Ensembl chr13:38,939,316...39,006,690
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JUN
Jun proto-oncogene, AP-1 transcription factor subunit
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PID
PID:200220
NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636
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KL
klotho
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RGD
PMID:16436388
RGD:1581599
NCBI chr11:9,427,236...9,479,251
Ensembl chr11:9,427,037...9,479,228
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KLB
klotho beta
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PID
PID:200220
NCBI chr 8:30,653,434...30,696,123
Ensembl chr 8:30,653,572...30,691,349
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MAPK1
mitogen-activated protein kinase 1
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PID
PID:200220
NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513
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MAPK3
mitogen-activated protein kinase 3
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PID
PID:200220
NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
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MET
MET proto-oncogene, receptor tyrosine kinase
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PID
PID:200220
NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512
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MMP9
matrix metallopeptidase 9
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PID
PID:200220
NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
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NCAM1
neural cell adhesion molecule 1
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PID
PID:200220
NCBI chr 9:40,628,602...40,960,605
Ensembl chr 9:40,628,631...40,960,591
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PAK4
p21 (RAC1) activated kinase 4
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PID
PID:200220
NCBI chr 6:47,869,604...47,914,185
Ensembl chr 6:47,869,577...47,914,182
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PDPK1
3-phosphoinositide dependent protein kinase 1
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PID
PID:200220
NCBI chr 3:39,429,928...39,512,623
Ensembl chr 3:39,432,058...39,512,601
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PIK3CA
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
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PID
PID:200220
NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587
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PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
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PID
PID:200220
NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609
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PLAU
plasminogen activator, urokinase
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PID
PID:200220
NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
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PLAUR
plasminogen activator, urokinase receptor
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PID
PID:200220
NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418
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PLCG1
phospholipase C gamma 1
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PID
PID:200220
NCBI chr17:43,810,003...43,844,553
Ensembl chr17:43,810,048...43,844,554
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PTK2B
protein tyrosine kinase 2 beta
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PID
PID:200220
NCBI chr14:11,063,662...11,194,196
Ensembl chr14:11,064,492...11,194,192
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PTPN11
protein tyrosine phosphatase non-receptor type 11
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PID
PID:200220
NCBI chr14:39,202,165...39,292,041
Ensembl chr14:39,202,169...39,292,003
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RPS6KA1
ribosomal protein S6 kinase A1
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PID
PID:200220
NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,077...83,950,963
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RUNX2
RUNX family transcription factor 2
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PID
PID:200220
NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,532...40,460,687
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SDC2
syndecan 2
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PID
PID:200220
NCBI chr 4:40,003,618...40,129,483
Ensembl chr 4:40,001,395...40,129,697
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SHC1
SHC adaptor protein 1
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PID
PID:200220
NCBI chr 4:94,818,226...94,831,766
Ensembl chr 4:94,810,875...94,831,765
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SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1
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PID
PID:200220
NCBI chr 3:101,209,568...101,366,057
Ensembl chr 3:101,209,641...101,362,723
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SPP1
secreted phosphoprotein 1
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PID
PID:200220
NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
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SPRY2
sprouty RTK signaling antagonist 2
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PID
PID:200220
NCBI chr11:52,153,695...52,158,766
Ensembl chr11:52,153,704...52,159,156
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SRC
SRC proto-oncogene, non-receptor tyrosine kinase
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PID
PID:200220
NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860
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SSH1
slingshot protein phosphatase 1
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PID
PID:200220
NCBI chr14:41,963,946...42,030,842
Ensembl chr14:41,968,466...42,025,726
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STAT1
signal transducer and activator of transcription 1
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PID
PID:200220
NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
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STAT5B
signal transducer and activator of transcription 5B
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PID
PID:200220
NCBI chr12:20,498,103...20,574,365
Ensembl chr12:20,508,404...20,574,266
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