PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: fibroblast growth factor signaling pathway
Accession: PW:0000328
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Definition: The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and it relies on the Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
Synonyms: related_synonym: FGF signaling pathway; Signaling by FGFR; fibroblast growth factor receptor signaling pathway
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Akt1
AKT serine/threonine kinase 1
ISO
PID
PID:200220
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Bglap
bone gamma-carboxyglutamate protein
ISO
PID
PID:200220
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
ISO
PID
PID:200220
NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
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Cbl
Cbl proto-oncogene
ISO
PID
PID:200220
NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:44,489,410...44,571,176
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Cdh1
cadherin 1
ISO
PID
PID:200220
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
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PID
PID:200220
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
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Ctnnd1
catenin delta 1
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PID
PID:200220
NCBI chr 3:90,090,025...90,141,247
Ensembl chr 3:69,683,313...69,734,516
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Cttn
cortactin
ISO
PID
PID:200220
NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:199,599,710...199,635,164
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Fgf1
fibroblast growth factor 1
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PID
PID:200220
NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
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Fgf17
fibroblast growth factor 17
ISO
PID
PID:200220
NCBI chr15:45,711,498...45,717,622
Ensembl chr15:45,711,998...45,717,063
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Fgf18
fibroblast growth factor 18
ISO
PID
PID:200220
NCBI chr10:18,210,240...18,241,929
Ensembl chr10:17,706,174...17,736,818
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Fgf19
fibroblast growth factor 19
ISO
PID
PID:200220
NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:200,056,644...200,060,287
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Fgf2
fibroblast growth factor 2
ISO
PID
PID:200220
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
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Fgf23
fibroblast growth factor 23
ISO
PID
PID:200220
NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:159,914,272...159,923,821
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Fgf4
fibroblast growth factor 4
ISO
PID
PID:200220
NCBI chr 1:209,453,229...209,457,085
Ensembl chr 1:200,024,056...200,025,466
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Fgf6
fibroblast growth factor 6
ISO
PID
PID:200220
NCBI chr 4:161,541,089...161,549,624
Ensembl chr 4:159,854,913...159,863,447
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Fgf8
fibroblast growth factor 8
ISO
PID
PID:200220
NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359
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Fgf9
fibroblast growth factor 9
IDA ISO
PID RGD
PMID:15231666
PID:200220, RGD:1304345
NCBI chr15:36,325,552...36,369,995
Ensembl chr15:32,210,074...32,253,309
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Fgfr1
Fibroblast growth factor receptor 1
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PID
PID:200220
NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350
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Fgfr2
fibroblast growth factor receptor 2
IMP ISO
PID RGD
PMID:15292181
PID:200220, RGD:2289848
NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626
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Fgfr3
fibroblast growth factor receptor 3
IDA
RGD
PMID:15231666
RGD:1304345
NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341
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Fgfr4
fibroblast growth factor receptor 4
ISO
PID
PID:200220
NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,461,547...9,476,242
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200220
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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Frs2
fibroblast growth factor receptor substrate 2
ISO
PID
PID:200220
NCBI chr 7:54,597,182...54,678,656
Ensembl chr 7:52,711,257...52,792,743
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Gab1
GRB2-associated binding protein 1
ISO
PID
PID:200220
NCBI chr19:44,035,693...44,143,617
Ensembl chr19:27,131,262...27,239,236
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Grb2
growth factor receptor bound protein 2
ISO
PID
PID:200220
NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309
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Hgf
hepatocyte growth factor
ISO
PID
PID:200220
NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409
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Il17rd
interleukin 17 receptor D
ISO
PID
PID:200220
NCBI chr16:2,235,172...2,489,827
Ensembl chr16:2,228,287...2,292,556
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
PID
PID:200220
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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Kl
Klotho
ISO
RGD
PMID:16436388
RGD:1581599
NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080
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Klb
klotho beta
ISO
PID
PID:200220
NCBI chr14:43,253,963...43,304,532
Ensembl chr14:42,899,510...42,950,799
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Mapk1
mitogen activated protein kinase 1
ISO
PID
PID:200220
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
ISO
PID
PID:200220
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Met
MET proto-oncogene, receptor tyrosine kinase
ISO
PID
PID:200220
NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876
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Mmp9
matrix metallopeptidase 9
ISO
PID
PID:200220
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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Ncam1
neural cell adhesion molecule 1
ISO
PID
PID:200220
NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014
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Pak4
p21 (RAC1) activated kinase 4
ISO
PID
PID:200220
NCBI chr 1:92,977,437...93,016,721
Ensembl chr 1:83,849,904...83,859,413
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Pdpk1
3-phosphoinositide dependent protein kinase-1
ISO
PID
PID:200220
NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
PID
PID:200220
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
PID
PID:200220
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
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Plau
plasminogen activator, urokinase
ISO
PID
PID:200220
NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
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Plaur
plasminogen activator, urokinase receptor
ISO
PID
PID:200220
NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595
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Plcg1
phospholipase C, gamma 1
ISO
PID
PID:200220
NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330
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Ptk2b
protein tyrosine kinase 2 beta
ISO
PID
PID:200220
NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
ISO
PID
PID:200220
NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925
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Rps6ka1
ribosomal protein S6 kinase A1
ISO
PID
PID:200220
NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:146,079,021...146,118,272
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Runx2
RUNX family transcription factor 2
ISO
PID
PID:200220
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
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Sdc2
syndecan 2
ISO
PID
PID:200220
NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081
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Shc1
SHC adaptor protein 1
ISO
PID
PID:200220
NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536
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Sos1
SOS Ras/Rac guanine nucleotide exchange factor 1
ISO
PID
PID:200220
NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107
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Spp1
secreted phosphoprotein 1
ISO
PID
PID:200220
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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Spry2
sprouty RTK signaling antagonist 2
ISO
PID
PID:200220
NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
ISO
PID
PID:200220
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
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Ssh1
slingshot protein phosphatase 1
ISO
PID
PID:200220
NCBI chr12:48,281,756...48,343,812
Ensembl chr12:42,621,135...42,683,274
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Stat1
signal transducer and activator of transcription 1
ISO
PID
PID:200220
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
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Stat5b
signal transducer and activator of transcription 5B
ISO
PID
PID:200220
NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668
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