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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:fibroblast growth factor signaling pathway
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Accession:PW:0000328 term browser browse the term
Definition:The family of fibroblast growth factors (FGF) comprises 22 ligands classified into seven phylogenetic subfamilies and three groups by mode of action: the intracellular intracrine and the extracellular paracrine or canonical and endocrine or hormone-like groups. The paracrine subfamilies signal via the fibroblast growth factor receptors (FGFR), receptor tyrosine kinases (RTK). The endocrine subfamily is FGFR-dependent but the affinity towards the receptors is low and it relies on the Klotho family of transmembrane proteins. The intracrine subfamily is FGFR-independent. Overall, the pathway plays important roles during embryonic and postnatal development, neuromodulation, mineral metabolism and homeostasis. Deregulation of the pathway has been associated with neoplastic and metabolic diseases.
Synonyms:related_synonym: FGF signaling pathway;   Signaling by FGFR;   fibroblast growth factor receptor signaling pathway



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fibroblast growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200220 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bglap bone gamma-carboxyglutamate protein ISO PID PID:200220 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO PID PID:200220 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Cbl Cbl proto-oncogene ISO PID PID:200220 NCBI chr 8:53,384,656...53,468,067
Ensembl chr 8:44,489,410...44,571,176
JBrowse link
G Cdh1 cadherin 1 ISO PID PID:200220 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 ISO PID PID:200220 NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Ctnnd1 catenin delta 1 ISO PID PID:200220 NCBI chr 3:90,090,025...90,141,247
Ensembl chr 3:69,683,313...69,734,516
JBrowse link
G Cttn cortactin ISO PID PID:200220 NCBI chr 1:209,029,048...209,064,577
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Fgf1 fibroblast growth factor 1 ISO PID PID:200220 NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf17 fibroblast growth factor 17 ISO PID PID:200220 NCBI chr15:45,711,498...45,717,622
Ensembl chr15:45,711,998...45,717,063
JBrowse link
G Fgf18 fibroblast growth factor 18 ISO PID PID:200220 NCBI chr10:18,210,240...18,241,929
Ensembl chr10:17,706,174...17,736,818
JBrowse link
G Fgf19 fibroblast growth factor 19 ISO PID PID:200220 NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Fgf2 fibroblast growth factor 2 ISO PID PID:200220 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf23 fibroblast growth factor 23 ISO PID PID:200220 NCBI chr 4:161,600,439...161,609,991
Ensembl chr 4:159,914,272...159,923,821
JBrowse link
G Fgf4 fibroblast growth factor 4 ISO PID PID:200220 NCBI chr 1:209,453,229...209,457,085
Ensembl chr 1:200,024,056...200,025,466
JBrowse link
G Fgf6 fibroblast growth factor 6 ISO PID PID:200220 NCBI chr 4:161,541,089...161,549,624
Ensembl chr 4:159,854,913...159,863,447
JBrowse link
G Fgf8 fibroblast growth factor 8 ISO PID PID:200220 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Fgf9 fibroblast growth factor 9 IDA
ISO
PID
RGD
PMID:15231666 PID:200220, RGD:1304345 NCBI chr15:36,325,552...36,369,995
Ensembl chr15:32,210,074...32,253,309
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 ISO PID PID:200220 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 IMP
ISO
PID
RGD
PMID:15292181 PID:200220, RGD:2289848 NCBI chr 1:194,175,703...194,280,914
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 IDA RGD PMID:15231666 RGD:1304345 NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO PID PID:200220 NCBI chr17:9,466,686...9,481,423
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200220 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 ISO PID PID:200220 NCBI chr 7:54,597,182...54,678,656
Ensembl chr 7:52,711,257...52,792,743
JBrowse link
G Gab1 GRB2-associated binding protein 1 ISO PID PID:200220 NCBI chr19:44,035,693...44,143,617
Ensembl chr19:27,131,262...27,239,236
JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO PID PID:200220 NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Hgf hepatocyte growth factor ISO PID PID:200220 NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Il17rd interleukin 17 receptor D ISO PID PID:200220 NCBI chr16:2,235,172...2,489,827
Ensembl chr16:2,228,287...2,292,556
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO PID PID:200220 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kl Klotho ISO RGD PMID:16436388 RGD:1581599 NCBI chr12:5,326,003...5,367,016
Ensembl chr12:490,399...530,080
JBrowse link
G Klb klotho beta ISO PID PID:200220 NCBI chr14:43,253,963...43,304,532
Ensembl chr14:42,899,510...42,950,799
JBrowse link
G Mapk1 mitogen activated protein kinase 1 ISO PID PID:200220 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 ISO PID PID:200220 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase ISO PID PID:200220 NCBI chr 4:46,756,823...46,864,041
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO PID PID:200220 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Ncam1 neural cell adhesion molecule 1 ISO PID PID:200220 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Pak4 p21 (RAC1) activated kinase 4 ISO PID PID:200220 NCBI chr 1:92,977,437...93,016,721
Ensembl chr 1:83,849,904...83,859,413
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO PID PID:200220 NCBI chr10:13,610,000...13,687,226
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO PID PID:200220 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200220 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plau plasminogen activator, urokinase ISO PID PID:200220 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor ISO PID PID:200220 NCBI chr 1:89,181,363...89,196,308
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcg1 phospholipase C, gamma 1 ISO PID PID:200220 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta ISO PID PID:200220 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 ISO PID PID:200220 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 ISO PID PID:200220 NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Runx2 RUNX family transcription factor 2 ISO PID PID:200220 NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sdc2 syndecan 2 ISO PID PID:200220 NCBI chr 7:66,012,405...66,125,101
Ensembl chr 7:64,127,110...64,241,081
JBrowse link
G Shc1 SHC adaptor protein 1 ISO PID PID:200220 NCBI chr 2:177,135,649...177,147,257
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 ISO PID PID:200220 NCBI chr 6:20,286,117...20,363,350
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Spp1 secreted phosphoprotein 1 ISO PID PID:200220 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 ISO PID PID:200220 NCBI chr15:89,106,809...89,111,926
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200220 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Ssh1 slingshot protein phosphatase 1 ISO PID PID:200220 NCBI chr12:48,281,756...48,343,812
Ensembl chr12:42,621,135...42,683,274
JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200220 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat5b signal transducer and activator of transcription 5B ISO PID PID:200220 NCBI chr10:86,205,148...86,276,178
Ensembl chr10:85,705,670...85,775,668
JBrowse link

Term paths to the root
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  pathway 6091
    signaling pathway 2635
      growth factor signaling pathway 523
        fibroblast growth factor signaling pathway 56
          altered fibroblast growth factor signaling pathway + 0
          endocrine fibroblast growth factor signaling pathway + 0
          intracrine fibroblast growth factor signaling pathway + 0
          paracrine fibroblast growth factor signaling pathway + 0
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