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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:altered growth factor signaling pathway
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Accession:PW:0000298 term browser browse the term
Definition:Those growth factor mediated signaling pathways that deviate from what their normal course should be. Aberrant growth factor mediated pathways, alone or in combination with other pathways underlie various diseases.

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altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor ISO RGD PMID:19506583 RGD:5490965 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:20519133, PMID:19506583, PMID:20951313 RGD:5133241, RGD:5490965, RGD:5133242 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19078924, PMID:21277552 RGD:4143515, RGD:5133243 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Tgfa transforming growth factor alpha ISO RGD PMID:19506583 RGD:5490965 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344 		JBrowse link
altered scatter factor/hepatocyte growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:20519133, PMID:19506583, PMID:21277552, PMID:20951313 RGD:5133241, RGD:5490965, RGD:5133243, RGD:5133242 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665 		JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544, PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544, PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544, PMID:19506583, PMID:18772397, PMID:18662538 RGD:2306282, RGD:5490965, RGD:5490966, RGD:2308865 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199 		JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409, PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO RGD PMID:18313409, PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO RGD PMID:18313409, PMID:19506583, PMID:18772397, PMID:17613544, PMID:18662538 RGD:2299005, RGD:5490965, RGD:5490966, RGD:2306282, RGD:2308865 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494 		JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599 		JBrowse link
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
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