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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:altered ubiquitin/proteasome degradation pathway
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Accession:PW:0000294 term browser browse the term
Definition:An ubiquitin/proteasome degradation pathway that deviates from what its normal course should be. Aberrations in the pathway have been implicated in a number of diseases. Examples include certain malignancies, disorders of the immune and inflammatory responses and neurodegeneration.


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altered ubiquitin/proteasome degradation pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Snca synuclein alpha ISS RGD PMID:14556719 RGD:1302872 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Uba1y ubiquitin-activating enzyme, Chr Y IMP RGD PMID:11020223 RGD:1302873 NCBI chr  Y:457,617...480,306
Ensembl chr  Y:483,578...504,038 		JBrowse link
G Ube2d2b ubiquitin-conjugating enzyme E2D 2B IMP RGD PMID:11020223 RGD:1302873 NCBI chr14:2,060,926...2,062,400
Ensembl chr14:2,048,235...2,063,764 		JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 IMP RGD PMID:11020223 RGD:1302873 NCBI chr 2:223,868,397...223,899,606
Ensembl chr 2:226,540,531...226,573,144 		JBrowse link
G Ube2g1 ubiquitin-conjugating enzyme E2G 1 IMP RGD PMID:11020223 RGD:1302873 NCBI chr10:57,225,963...57,306,748
Ensembl chr10:57,724,485...57,807,853 		JBrowse link
G Ube2i ubiquitin-conjugating enzyme E2I IMP RGD PMID:11020223 RGD:1302873 NCBI chr10:14,277,749...14,294,681
Ensembl chr10:70,199,041...70,199,866
Ensembl chr10:70,199,041...70,199,866 		JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N IMP RGD PMID:11020223 RGD:1302873 NCBI chr 7:30,154,330...30,184,373 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      pathway pertinent to protein folding, sorting, modification, translocation and degradation 316
        protein degradation pathway 313
          ubiquitin, ubiquitin-like/proteasome degradation pathway 177
            ubiquitin/proteasome degradation pathway 177
              altered ubiquitin/proteasome degradation pathway 7
paths to the root