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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:cell death pathway
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Accession:PW:0000275 term browser browse the term
Definition:A cell death pathway represents the particular series of events leading to the demise of a whole cell or parts of its contents. It plays an essential role in cellular and tissue homeostasis. Biochemical and morphological characteristics are used in the classification of various forms of cell death. Deregulation of cell death can contribute to the development of cancer and neurodegeneration.
Synonyms:related_synonym: cell death


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altered mitochondrial autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pink1 PTEN induced kinase 1 ISO RGD PMID:24735649 RGD:10450527 NCBI chr 1:19,895,179...19,907,485 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24735649 RGD:10450527 NCBI chr 2:189,645,291...190,070,073 JBrowse link
apoptotic cell death pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 ISO RGD PMID:10646526 RGD:38596326 NCBI chr13:41,290,923...41,309,762 JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:26485208 RGD:12910856 NCBI chr 1:12,870,233...12,900,603 JBrowse link
G Smn1 survival of motor neuron 1, telomeric ISO RGD PMID:11303798 RGD:1358254 NCBI chr 3:196,465,716...196,475,682 JBrowse link
G Snca synuclein alpha ISO RGD PMID:16837598 RGD:13506279 NCBI chr 6:81,929,667...82,027,272 JBrowse link
autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp2 acid phosphatase 2, lysosomal ISO RGD PMID:18690537 RGD:4892631 NCBI chr 5:65,366,595...65,376,348 JBrowse link
G Atg10 autophagy related 10 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr 3:205,162,165...205,286,691 JBrowse link
G Atg12 autophagy related 12 ISO RGD PMID:15325588 PMID:18059433 PMID:20034776 RGD:1643329 RGD:2301217 RGD:4889529 NCBI chr15:40,311,008...40,320,469 JBrowse link
G Atg13 autophagy related 13 ISO RGD PMID:20034776 RGD:4889529 NCBI chr 5:65,819,514...65,854,600 JBrowse link
G Atg14 autophagy related 14 ISO RGD PMID:20034776 RGD:4889529 NCBI chr12:75,469,676...75,500,067 JBrowse link
G Atg16l1 autophagy related 16 like 1 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr 4:159,870,694...159,906,616 JBrowse link
G Atg16l2 autophagy related 16 like 2 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr 2:99,597,811...99,610,345 JBrowse link
G Atg3 autophagy related 3 ISO RGD PMID:15325588 PMID:17110912 PMID:20034776 RGD:1643237 RGD:1643329 RGD:4889529 NCBI chr 4:29,921,959...29,950,113 JBrowse link
G Atg4b autophagy related 4B cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr 4:165,673,101...165,704,342 JBrowse link
G Atg4c autophagy related 4C cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr 1:55,261,444...55,333,988 JBrowse link
G Atg4d autophagy related 4D cysteine peptidase ISO RGD PMID:15325588 RGD:1643329 NCBI chr 8:17,530,216...17,539,497 JBrowse link
G Atg5 autophagy related 5 ISO RGD PMID:18059433 PMID:20034776 RGD:2301217 RGD:4889529 NCBI chr18:44,036,590...44,132,959 JBrowse link
G Atg7 autophagy related 7 ISO RGD PMID:15325588 PMID:17665967 PMID:20034776 RGD:1643198 RGD:1643329 RGD:4889529 NCBI chr 6:31,808,516...31,986,019 JBrowse link
G Atg9a autophagy related 9A ISO RGD PMID:20034776 RGD:4889529 NCBI chr 4:148,540,005...148,550,701 JBrowse link
G Atg9b autophagy related 9B ISO RGD PMID:20034776 RGD:4889529 NCBI chr 6:153,577,689...153,585,402 JBrowse link
G Becn1 beclin 1 ISO RGD PMID:15325588 PMID:16697404 PMID:20034776 RGD:1643194 RGD:1643329 RGD:4889529 NCBI chr 9:60,592,779...60,608,052 JBrowse link
G Chmp2b charged multivesicular body protein 2B ISO RGD PMID:19535733 RGD:4892619 NCBI chr 4:76,805,368...76,830,071 JBrowse link
G Chmp3 charged multivesicular body protein 3 ISO RGD PMID:19535733 RGD:4892619 NCBI chr 6:74,567,087...74,615,545 JBrowse link
G Gabarap GABA type A receptor-associated protein ISO RGD PMID:15325588 PMID:20562859 RGD:1643329 RGD:4890444 NCBI chr 9:49,598,028...49,601,746 JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 ISO RGD PMID:20562859 RGD:4890444 NCBI chr 6:18,056,732...18,065,985 JBrowse link
G Gabarapl2 GABA type A receptor associated protein like 2 ISO RGD PMID:15325588 PMID:20562859 RGD:1643329 RGD:4890444 NCBI chr17:31,632,346...31,633,514 JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate ISO RGD PMID:19535733 RGD:4892619 NCBI chr 9:63,540,680...63,558,463 JBrowse link
G Lamp1 lysosomal associated membrane protein 1 ISO RGD PMID:18690537 PMID:20548331 RGD:4892310 RGD:4892631 NCBI chr13:70,516,414...70,532,976 JBrowse link
G Lamp2 lysosomal associated membrane protein 2 ISO RGD PMID:20548331 RGD:4892310 NCBI chr  X:101,913,626...101,950,698 JBrowse link
G Map1lc3a microtubule associated protein 1 light chain 3 alpha ISO RGD PMID:15325588 PMID:17665967 PMID:20562859 RGD:1643198 RGD:1643329 RGD:4890444 NCBI chr 5:134,631,977...134,633,706 JBrowse link
G Map1lc3b microtubule associated protein 1 light chain 3 beta ISO RGD PMID:15325588 PMID:20562859 RGD:1643329 RGD:4890444 NCBI chr17:41,253,179...41,260,892 JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 ISO RGD PMID:20034776 RGD:4889529 NCBI chr15:13,687,435...13,765,091 JBrowse link
G Pik3r4 phosphoinositide-3-kinase regulatory subunit 4 ISO RGD PMID:20034776 RGD:4889529 NCBI chr 8:96,924,882...96,979,175 JBrowse link
G Rab11a RAB11A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 8:59,024,080...59,046,420 JBrowse link
G Rab33b RAB33B, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 3:102,961,989...102,972,387 JBrowse link
G Rab5a RAB5A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 4:90,508,209...90,539,230 JBrowse link
G Rab7a RAB7A, member RAS oncogene family ISO RGD PMID:20548331 RGD:4892310 NCBI chr 6:58,276,096...58,320,896 JBrowse link
G Rb1cc1 RB1 inducible coiled-coil 1 ISO RGD PMID:20034776 RGD:4889529 NCBI chr 1:141,399,037...141,464,457 JBrowse link
G Rubcn rubicon autophagy regulator ISO RGD PMID:20034776 RGD:4889529 NCBI chr 4:17,627,756...17,673,586 JBrowse link
G Snf8 SNF8 subunit of ESCRT-II ISO RGD PMID:19535733 RGD:4892619 NCBI chr 9:58,347,892...58,360,450 JBrowse link
G Tsg101 tumor susceptibility 101 ISO RGD PMID:19535733 RGD:4892619 NCBI chr 2:152,457,588...152,486,918 JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO RGD PMID:15325588 PMID:20034776 RGD:1643329 RGD:4889529 NCBI chr16:43,533,436...43,560,100 JBrowse link
G Uvrag UV radiation resistance associated ISO RGD PMID:20034776 RGD:4889529 NCBI chr 2:97,160,014...97,417,614 JBrowse link
G Vamp3 vesicle associated membrane protein 3 ISO RGD PMID:20548331 RGD:4892310 NCBI chr 1:9,714,347...9,725,436 JBrowse link
G Vamp7 vesicle associated membrane protein 7 ISO RGD PMID:20548331 RGD:4892310 NCBI chr16:15,277,986...15,303,416 JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A ISO RGD PMID:19535733 RGD:4892619 NCBI chr17:26,756,167...26,770,097 JBrowse link
chaperone mediated autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag1 BAG cochaperone 1 ISO RGD PMID:25724482 RGD:10755685 NCBI chr 1:117,234,366...117,246,964 JBrowse link
G Ctsb cathepsin B ISO RGD PMID:24323530 RGD:10755730 NCBI chr12:61,229,068...61,249,589 JBrowse link
G Ctsd cathepsin D ISO RGD PMID:24323530 PMID:25766616 RGD:10755729 RGD:10755730 NCBI chr 2:7,091,289...7,103,344 JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 ISO RGD PMID:25724482 RGD:10755685 NCBI chr17:16,655,029...16,658,727 JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 ISO RGD PMID:24281265 PMID:25724482 RGD:10755322 RGD:10755685 NCBI chr 8:72,664,717...72,668,811 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:25724482 RGD:10755685 NCBI chr 7:128,255,520...128,260,875 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 ISO RGD PMID:24281265 PMID:25724482 RGD:10755322 RGD:10755685 NCBI chr 8:35,401,907...35,405,851 JBrowse link
G Lamp2 lysosomal associated membrane protein 2 ISO RGD PMID:24281265 PMID:25724482 RGD:10755322 RGD:10755685 NCBI chr  X:101,913,626...101,950,698 JBrowse link
G St13 ST13 Hsp70 interacting protein ISO RGD PMID:25724482 RGD:10755685 NCBI chr 1:251,115,651...251,152,261 JBrowse link
G Stip1 stress induced phosphoprotein 1 ISO RGD PMID:25724482 RGD:10755685 NCBI chr 2:757,793...776,359 JBrowse link
extrinsic apoptotic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 ISO RGD PMID:17082813 RGD:2314187 NCBI chr13:41,290,923...41,309,762 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:17082813 RGD:2314187 NCBI chr 2:59,734,906...59,773,424 JBrowse link
G Casp8 caspase 8 ISO RGD PMID:17082813 RGD:2314187 NCBI chr 4:133,627,869...133,647,363 JBrowse link
G Fas Fas cell surface death receptor ISO germ cells RGD PMID:17195944 RGD:1626509 NCBI chr 2:33,897,209...33,930,625 JBrowse link
G Faslg Fas ligand ISO RGD PMID:16154149 RGD:1582433 NCBI chr10:41,080,568...41,093,454 JBrowse link
FasL mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO PID PID:200080 NCBI chr 7:130,247,175...130,267,462 JBrowse link
G Bid BH3 interacting domain death agonist ISO RGD
PID		 PMID:18090083 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 NCBI chr 6:25,844,885...25,854,347 JBrowse link
G Btk Bruton tyrosine kinase ISO PID PID:200080 NCBI chr  X:86,848,108...86,886,678 JBrowse link
G Casp3 caspase 3 ISO RGD
PID		 PMID:19239902 PID:200080 RGD:4143196 NCBI chr13:41,290,923...41,309,762 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19239902 RGD:4143196 NCBI chr 2:59,734,906...59,773,424 JBrowse link
G Casp8 caspase 8 ISO RGD
PID		 PMID:18090083 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 NCBI chr 4:133,627,869...133,647,363 JBrowse link
G Cflar CASP8 and FADD like apoptosis regulator ISO PID
RGD		 PMID:19107989 PMID:19239902 PID:200080 RGD:4143196 RGD:8662854 NCBI chr 4:133,705,160...133,753,373 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200080 NCBI chr 2:43,604,916...43,639,986 JBrowse link
G Cltc clathrin heavy chain ISO PID PID:200080 NCBI chr 9:84,023,834...84,080,666 JBrowse link
G Ezr ezrin ISO PID PID:200080 NCBI chr 2:192,379,000...192,422,154 JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:19239902 PID:200080 RGD:4143196 NCBI chr 2:5,142,335...5,145,109 JBrowse link
G Faim2 Fas apoptotic inhibitory molecule 2 ISO PID PID:200080 NCBI chr 1:272,310,308...272,336,614 JBrowse link
G Fas Fas cell surface death receptor ISO PID
RGD		 PMID:18090083 PMID:19107989 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 RGD:8662854 NCBI chr 2:33,897,209...33,930,625 JBrowse link
G Faslg Fas ligand ISO RGD
PID		 PMID:18090083 PMID:19239902 PID:200080 RGD:2314002 RGD:4143196 NCBI chr10:41,080,568...41,093,454 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200080 NCBI chr13:63,723,847...63,773,590 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200080 NCBI chr  X:128,431,077...128,451,167 JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 ISO PID PID:200080 NCBI chr 9:78,781,960...78,902,641 JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 ISO PID PID:200080 NCBI chr16:2,371,589...2,380,894 JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200080 NCBI chr 3:185,235,931...185,301,022 JBrowse link
G Mapk10 mitogen-activated protein kinase 10 ISO PID PID:200080 NCBI chr11:13,027,088...13,297,722 JBrowse link
G Mapk11 mitogen-activated protein kinase 11 ISO PID PID:200080 NCBI chr 1:258,445,695...258,452,691 JBrowse link
G Mapk14 mitogen-activated protein kinase 14 ISO PID PID:200080 NCBI chr18:5,112,956...5,172,783 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200080 NCBI chr13:9,106,121...9,183,372 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO PID PID:200080 NCBI chr 9:32,516,137...32,557,472 JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase 1 ISO PID PID:200080 NCBI chr 9:1,370,263...1,439,206 JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200080 NCBI chr 3:122,534,305...122,612,749 JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO PID PID:200080 NCBI chr 8:90,377,917...90,480,574 JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO PID PID:200080 NCBI chr 1:11,092,427...11,119,538 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200080 NCBI chr 3:195,528,436...195,613,095 JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200080 NCBI chr13:13,009,782...13,018,485 JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO PID PID:200080 NCBI chr 1:39,901,346...39,970,818 JBrowse link
G Rfc1 replication factor C subunit 1 ISO PID PID:200080 NCBI chr11:22,279,164...22,352,880 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID PID:200080 NCBI chr14:52,581,837...52,608,497 JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200080 NCBI chr 2:104,390,759...104,394,682 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO PID PID:200080 NCBI chr 5:136,801,406...136,816,184 JBrowse link
G Syk spleen associated tyrosine kinase ISO PID PID:200080 NCBI chr14:70,903,375...70,973,626 JBrowse link
intrinsic apoptotic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 ISO RGD PMID:18931364 RGD:2313998 NCBI chr 1:170,071,689...170,158,638 JBrowse link
G Bad BCL2 associated agonist of cell death ISO RGD PMID:15632274 PMID:19641503 RGD:1579966 RGD:2314029 NCBI chr 2:844,289...853,573 JBrowse link
G Bak1 BCL2 antagonist/killer 1 ISO RGD PMID:17322918 PMID:18817839 RGD:2313963 RGD:2313975 NCBI chr18:6,780,175...6,788,702 JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO RGD PMID:15632274 PMID:17322918 PMID:18817839 PMID:18931364 PMID:18959742 RGD:1579966 RGD:2313963 RGD:2313975 RGD:2313998 RGD:2314140 NCBI chr 2:154,044,388...154,049,903 JBrowse link
G Bbc3 BCL2 binding component 3 ISO RGD PMID:19095966 PMID:19641503 RGD:2313994 RGD:2314029 NCBI chr 2:172,743,801...172,752,099 JBrowse link
G Bcl2a1 BCL2 related protein A1 ISO RGD PMID:17322918 RGD:2313975 NCBI chr 8:82,149,101...82,158,167 JBrowse link
G Bcl2l1 BCL2 like 1 ISO RGD PMID:15632274 PMID:17322918 PMID:18959742 RGD:1579966 RGD:2313975 RGD:2314140 NCBI chr 5:132,108,601...132,158,316 JBrowse link
G Bcl2l10 BCL2 like 10 ISO RGD PMID:17322918 RGD:2313975 NCBI chr 8:69,638,180...69,642,874 JBrowse link
G Bcl2l11 BCL2 like 11 ISO RGD PMID:19641503 RGD:2314029 NCBI chr 5:106,918,572...107,080,263 JBrowse link
G Bid BH3 interacting domain death agonist ISO RGD PMID:18090083 PMID:18931364 PMID:19641503 RGD:2313998 RGD:2314002 RGD:2314029 NCBI chr 6:25,844,885...25,854,347 JBrowse link
G Bik BCL2 interacting killer ISO RGD PMID:19641503 RGD:2314029 NCBI chr 1:252,943,683...252,962,196 JBrowse link
G Bmf Bcl2 modifying factor ISO RGD PMID:19641503 RGD:2314029 NCBI chr 5:96,681,539...96,702,154 JBrowse link
G Bnip1 BCL2 interacting protein 1 ISO RGD PMID:12714334 PMID:19641503 RGD:2314029 RGD:634759 NCBI chr 9:4,655,981...4,668,445 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO RGD PMID:14972662 PMID:19641503 RGD:2314028 RGD:2314029 NCBI chr 2:62,913,006...62,930,228 JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO RGD PMID:19641503 RGD:2314029 NCBI chr12:57,487,450...57,510,400 JBrowse link
G Bok BCL2 family apoptosis regulator BOK ISO RGD PMID:9356461 PMID:17322918 RGD:2313975 RGD:70678 NCBI chr 4:165,611,574...165,622,485 JBrowse link
G Casp3 caspase 3 ISO RGD PMID:17082813 PMID:17869439 PMID:18090083 PMID:18817839 PMID:18931364 RGD:2313963 RGD:2313998 RGD:2314002 RGD:2314187 RGD:2314390 NCBI chr13:41,290,923...41,309,762 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:17082813 RGD:2314187 NCBI chr 2:59,734,906...59,773,424 JBrowse link
G Casp9 caspase 9 ISO RGD PMID:17082813 PMID:17869439 PMID:18090083 PMID:18817839 PMID:18931364 RGD:2313963 RGD:2313998 RGD:2314002 RGD:2314187 RGD:2314390 NCBI chr 1:16,337,170...16,355,659 JBrowse link
G Fas Fas cell surface death receptor ISO germ cells RGD PMID:17195944 RGD:1626509 NCBI chr 2:33,897,209...33,930,625 JBrowse link
G Hrk harakiri, BCL2 interacting protein ISO RGD PMID:10075695 PMID:17428807 PMID:19641503 RGD:2290488 RGD:2314029 RGD:70327 NCBI chr16:35,658,305...35,658,581 JBrowse link
G Htra2 HtrA serine peptidase 2 ISO RGD PMID:16978742 RGD:2314385 NCBI chr 6:63,170,554...63,173,711 JBrowse link
G LOC116903823 cytochrome c, somatic ISO RGD PMID:18817839 PMID:18931364 RGD:2313963 RGD:2313998 NCBI chr 6:90,515,515...90,517,245 JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member ISO RGD PMID:9356461 PMID:17322918 RGD:2313975 RGD:70678 NCBI chr 3:61,612,607...61,617,028 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO RGD PMID:18959742 PMID:19641503 RGD:2314029 RGD:2314140 NCBI chr15:64,808,452...64,813,433 JBrowse link
G Xiap X-linked inhibitor of apoptosis ISO RGD PMID:17869439 RGD:2314390 NCBI chr  X:108,899,568...108,940,797 JBrowse link
mitochondrial autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambra1 autophagy and beclin 1 regulator 1 ISO RGD PMID:23065344 RGD:10401098 NCBI chr 5:65,873,993...66,062,789 JBrowse link
G Atg7 autophagy related 7 ISO RGD PMID:25840011 RGD:10400888 NCBI chr 6:31,808,516...31,986,019 JBrowse link
G Becn1 beclin 1 ISO RGD PMID:23065344 RGD:10401098 NCBI chr 9:60,592,779...60,608,052 JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO RGD PMID:23065344 PMID:25840011 RGD:10400888 RGD:10401098 NCBI chr 2:62,913,006...62,930,228 JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO RGD PMID:23065344 PMID:25840011 RGD:10400888 RGD:10401098 NCBI chr12:57,487,450...57,510,400 JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 ISO RGD PMID:25840011 RGD:10400888 NCBI chr 5:131,563,975...131,610,422 JBrowse link
G Csnk2a2 casein kinase 2 alpha 2 ISO RGD PMID:25840011 RGD:10400888 NCBI chr17:2,296,822...2,335,984 JBrowse link
G Csnk2b casein kinase 2 beta ISO RGD PMID:25840011 RGD:10400888 NCBI chr18:7,716,267...7,720,575 JBrowse link
G Fundc1 FUN14 domain containing 1 ISO RGD PMID:25840011 RGD:10400888 NCBI chr  X:4,663,804...4,679,310 JBrowse link
G Optn optineurin ISO RGD PMID:25995186 RGD:10401790 NCBI chr14:11,368,481...11,413,630 JBrowse link
G Parl presenilin associated rhomboid like ISO RGD PMID:25526784 RGD:10402124 NCBI chr 4:5,117,004...5,141,758 JBrowse link
G Pgam5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase ISO RGD PMID:25840011 RGD:10400888 NCBI chr16:44,087,747...44,094,698 JBrowse link
G Pink1 PTEN induced kinase 1 ISO RGD PMID:23065344 PMID:25840011 PMID:25995186 RGD:10400888 RGD:10401098 RGD:10401790 NCBI chr 1:19,895,179...19,907,485 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:23065344 PMID:25840011 PMID:25995186 RGD:10400888 RGD:10401098 RGD:10401790 NCBI chr 2:189,645,291...190,070,073 JBrowse link
G Sqstm1 sequestosome 1 ISO RGD PMID:23065344 PMID:25995186 RGD:10401098 RGD:10401790 NCBI chr 9:32,865,939...32,877,232 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:25840011 RGD:10400888 NCBI chr 5:136,801,406...136,816,184 JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 ISO RGD PMID:25526784 RGD:10402124 NCBI chr 6:153,060,026...153,066,199 JBrowse link
G Ube2l3 ubiquitin conjugating enzyme E2 L3 ISO RGD PMID:25995186 RGD:10401790 NCBI chr 4:2,436,946...2,475,581 JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 ISO RGD PMID:25840011 RGD:10400888 NCBI chr16:43,533,436...43,560,100 JBrowse link
G Usp15 ubiquitin specific peptidase 15 ISO RGD PMID:25995186 RGD:10401790 NCBI chr 1:201,512,856...201,604,859 JBrowse link
G Usp30 ubiquitin specific peptidase 30 ISO RGD PMID:25995186 RGD:10401790 NCBI chr16:39,845,271...39,869,261 JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO RGD PMID:25995186 RGD:10401790 NCBI chr 5:105,555,495...105,593,457 JBrowse link
Trail mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist ISO RGD PMID:17403612 PMID:19961901 RGD:4143170 RGD:4143171 NCBI chr 6:25,844,885...25,854,347 JBrowse link
G Casp3 caspase 3 ISO RGD PMID:17403612 PMID:19961901 RGD:4143170 RGD:4143171 NCBI chr13:41,290,923...41,309,762 JBrowse link
G Casp7 caspase 7 ISO RGD PMID:19961901 RGD:4143171 NCBI chr 2:59,734,906...59,773,424 JBrowse link
G Casp8 caspase 8 ISO RGD
PID		 PMID:17403612 PMID:19961901 PID:200068 RGD:4143170 RGD:4143171 NCBI chr 4:133,627,869...133,647,363 JBrowse link
G Cflar CASP8 and FADD like apoptosis regulator ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068 RGD:4143170 RGD:4143171 NCBI chr 4:133,705,160...133,753,373 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO PID PID:200068 NCBI chr 2:43,604,916...43,639,986 JBrowse link
G Dap3 death associated protein 3 ISO PID PID:200068 NCBI chr 3:64,737,250...64,756,451 JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:17403612 PMID:19961901 PID:200068 RGD:4143170 RGD:4143171 NCBI chr 2:5,142,335...5,145,109 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO PID PID:200068 NCBI chr13:63,723,847...63,773,590 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID PID:200068 NCBI chr  X:128,431,077...128,451,167 JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 ISO PID PID:200068 NCBI chr 9:45,295,943...45,392,383 JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200068 NCBI chr 3:185,235,931...185,301,022 JBrowse link
G Mapk1 mitogen-activated protein kinase 1 ISO PID PID:200068 NCBI chr 4:2,258,527...2,323,147 JBrowse link
G Mapk3 mitogen-activated protein kinase 3 ISO PID PID:200068 NCBI chr 2:75,131,760...75,138,057 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 ISO PID PID:200068 NCBI chr13:9,106,121...9,183,372 JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO PID PID:200068 NCBI chr 3:122,534,305...122,612,749 JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta ISO PID PID:200068 NCBI chr 8:90,377,917...90,480,574 JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta ISO PID PID:200068 NCBI chr 1:11,092,427...11,119,538 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 ISO PID PID:200068 NCBI chr 3:195,528,436...195,613,095 JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 ISO PID PID:200068 NCBI chr13:13,009,782...13,018,485 JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 ISO PID PID:200068 NCBI chr 1:39,901,346...39,970,818 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO PID PID:200068 NCBI chr14:52,581,837...52,608,497 JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200068 NCBI chr 2:104,390,759...104,394,682 JBrowse link
G Tnfsf10 TNF superfamily member 10 ISO RGD
PID		 PMID:17403612 PMID:19385008 PMID:19961901 PID:200068 RGD:2312745 RGD:4143170 RGD:4143171 NCBI chr 3:127,369,263...127,385,999 JBrowse link
G Tradd TNFRSF1A associated via death domain ISO PID PID:200068 NCBI chr17:24,986,301...24,991,886 JBrowse link
G Traf2 TNF receptor associated factor 2 ISO PID PID:200068 NCBI chr 5:11,631,318...11,656,299 JBrowse link
tumor necrosis factor mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 ADAM metallopeptidase domain 17 ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 7:37,864,815...37,911,293 JBrowse link
G Bag4 BAG cochaperone 4 ISO RGD
PID		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr13:60,713,289...60,733,770 JBrowse link
G Casp8 caspase 8 ISO PID PID:200102 NCBI chr 4:133,627,869...133,647,363 JBrowse link
G Cav1 caveolin 1 ISO PID PID:200102 NCBI chr 6:121,625,973...121,658,196 JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex ISO RGD
PID		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 2:43,604,916...43,639,986 JBrowse link
G Cyld CYLD lysine 63 deubiquitinase ISO RGD
PID		 PMID:21119682 PMID:23312890 PID:200102 RGD:7800734 RGD:7800735 NCBI chr 4:13,964,466...14,052,542 JBrowse link
G Fadd Fas associated via death domain ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 2:5,142,335...5,145,109 JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta ISO RGD
PID		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr13:63,723,847...63,773,590 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr  X:128,431,077...128,451,167 JBrowse link
G Itch itchy E3 ubiquitin protein ligase ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 5:134,494,345...134,582,451 JBrowse link
G Madd MAP kinase activating death domain ISO PID PID:200102 NCBI chr 5:65,305,138...65,350,073 JBrowse link
G Map2k7 mitogen-activated protein kinase kinase 7 ISO PID PID:200102 NCBI chr16:2,371,589...2,380,894 JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 ISO PID PID:200102 NCBI chr 3:185,235,931...185,301,022 JBrowse link
G Map3k3 mitogen-activated protein kinase kinase kinase 3 ISO PID PID:200102 NCBI chr 9:72,961,501...73,029,339 JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 2:216,449,154...216,650,582 JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ISO PID
RGD		 PMID:21135871 PID:200102 RGD:5490225 NCBI chr 1:111,003,753...111,061,041 JBrowse link
G Map4k2 mitogen-activated protein kinase kinase kinase kinase 2 ISO PID PID:200102 NCBI chr 2:1,329,898...1,345,075 JBrowse link
G Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 ISO PID PID:200102 NCBI chr 7:12,337,138...12,506,265 JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 ISO PID PID:200102 NCBI chr 4:116,159,452...116,284,969 JBrowse link
G Map4k5 mitogen-activated protein kinase kinase kinase kinase 5 ISO PID PID:200102 NCBI chr 7:83,470,972...83,563,479 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 ISO PID PID:200102 NCBI chr 3:23,398,553...23,512,176 JBrowse link
G Nrk Nik related kinase ISO PID PID:200102 NCBI chr  X:91,416,192...91,509,624 JBrowse link
G Nsmaf neutral sphingomyelinase activation associated factor ISO PID PID:200102 NCBI chr 1:136,530,936...136,590,438 JBrowse link
G Prkci protein kinase C iota ISO PID PID:200102 NCBI chr 3:125,230,654...125,288,515 JBrowse link
G Prkcz protein kinase C zeta ISO PID PID:200102 NCBI chr 1:5,350,189...5,461,946 JBrowse link
G Rack1 receptor for activated C kinase 1 ISO PID PID:200102 NCBI chr 9:31,400,835...31,406,395 JBrowse link
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 ISO RGD PMID:23085193 RGD:7800730 NCBI chr 5:131,641,110...131,657,817 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit ISO PID PID:200102 NCBI chr 2:2,045,437...2,055,534 JBrowse link
G Rffl ring finger and FYVE like domain containing E3 ubiquitin protein ligase ISO PID PID:200102 NCBI chr 9:87,646,166...87,710,475 JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 ISO RGD
PID		 PMID:12655295 PMID:23085193 PID:200102 RGD:2292150 RGD:7800730 NCBI chr14:52,581,837...52,608,497 JBrowse link
G Rnf11 ring finger protein 11 ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 1:45,384,780...45,408,061 JBrowse link
G Rnf31 ring finger protein 31 ISO RGD PMID:23085193 RGD:7800730 NCBI chr12:69,403,147...69,415,652 JBrowse link
G Sharpin SHANK associated RH domain interactor ISO RGD PMID:23085193 RGD:7800730 NCBI chr 1:248,681,587...248,685,897 JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 ISO PID PID:200102 NCBI chr 2:104,390,759...104,394,682 JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 ISO PID PID:200102 NCBI chr18:41,180,020...41,183,272 JBrowse link
G Sqstm1 sequestosome 1 ISO PID PID:200102 NCBI chr 9:32,865,939...32,877,232 JBrowse link
G Stat1 signal transducer and activator of transcription 1 ISO PID PID:200102 NCBI chr 4:123,267,793...123,306,466 JBrowse link
G Tab1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 ISO RGD
PID		 PMID:21135871 PID:200102 RGD:5490225 NCBI chr 1:249,898,434...249,927,523 JBrowse link
G Tab2 TGF-beta activated kinase 1 (MAP3K7) binding protein 2 ISO PID
RGD		 PMID:21135871 PID:200102 RGD:5490225 NCBI chr 2:229,104,413...229,151,692 JBrowse link
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 ISO RGD PMID:21135871 RGD:5490225 NCBI chr  X:79,870,398...79,890,592 JBrowse link
G Tax1bp1 Tax1 binding protein 1 ISO RGD PMID:21119682 PMID:23312890 RGD:7800734 RGD:7800735 NCBI chr 6:88,299,917...88,355,394 JBrowse link
G Tnf tumor necrosis factor ISO PID
RGD		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr18:7,795,823...7,798,458 JBrowse link
G Tnfaip3 TNF alpha induced protein 3 ISO RGD
PID		 PMID:21119682 PMID:23312890 PID:200102 RGD:7800734 RGD:7800735 NCBI chr 2:217,827,167...217,840,707 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A ISO RGD
PID		 PMID:12655295 PMID:20967881 PID:200102 RGD:2292150 RGD:5130945 NCBI chr 6:22,540,807...22,553,712 JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO RGD
PID		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr 1:13,578,144...13,609,316 JBrowse link
G Tnik TRAF2 and NCK interacting kinase ISO PID PID:200102 NCBI chr 3:126,006,757...126,399,096 JBrowse link
G Tradd TNFRSF1A associated via death domain ISO RGD
PID		 PMID:12655295 PID:200102 RGD:2292150 NCBI chr17:24,986,301...24,991,886 JBrowse link
G Traf1 TNF receptor associated factor 1 ISO PID PID:200102 NCBI chr 5:691,768...711,646 JBrowse link
G Traf2 TNF receptor associated factor 2 ISO RGD
PID		 PMID:12655295 PMID:20967881 PMID:23085193 PID:200102 RGD:2292150 RGD:5130945 RGD:7800730 NCBI chr 5:11,631,318...11,656,299 JBrowse link
G Traf5 TNF receptor associated factor 5 ISO RGD PMID:23085193 RGD:7800730 NCBI chr10:70,082,392...70,129,712 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3798
    regulatory pathway 2365
      cell death pathway 172
        altered cell death pathway + 2
        non-programmed cell death pathway + 0
        programmed cell death pathway + 172
paths to the root