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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:altered signaling pathway
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Accession:PW:0000264 term browser browse the term
Definition:Those signaling pathways that deviate from what their normal course should be. Aberrant signaling pathways, alone or in combination with other pathways underlie many conditions, disorders and/or diseases.


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altered androgen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor ISO RGD PMID:18008377, PMID:23759327 RGD:2326139, RGD:8693397 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701
JBrowse link
altered ephrin - ephrin receptor bidirectional signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna1 ephrin A1 ISS Present in gastrointestinal, liver and kidney cancers. RGD PMID:15561600 RGD:1304509 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Efna2 ephrin A2 ISS RGD PMID:15561600 RGD:1304509 NCBI chr 7:12,382,636...12,393,266
Ensembl chr 7:12,382,636...12,393,266
JBrowse link
G Efna3 ephrin A3 ISS Present in neurobalstoma, neural cancers and leukemia. RGD PMID:15561600 RGD:1304509 NCBI chr 2:188,636,304...188,645,302
Ensembl chr 2:188,637,852...188,645,196
JBrowse link
G Efnb1 ephrin B1 ISS Present in neuroblastoma, leukemia and lung cancer RGD PMID:15561600 RGD:1304509 NCBI chr  X:68,891,227...68,904,034
Ensembl chr  X:68,891,227...68,904,038
JBrowse link
G Efnb3 ephrin B3 ISS Present in neuroblastomas and neural cancers RGD PMID:15561600 RGD:1304509 NCBI chr10:56,161,431...56,168,819
Ensembl chr10:56,161,432...56,167,426
JBrowse link
G Epha3 Eph receptor A3 ISS Present in neuroblastomas, neural cancers, leukemias and lymphomas. RGD PMID:15561600 RGD:1304509 NCBI chr11:421,253...783,037
Ensembl chr11:421,135...782,954
JBrowse link
G Epha7 Eph receptor A7 ISS RGD PMID:15561600 RGD:1304509 NCBI chr 5:43,602,744...43,761,198
Ensembl chr 5:43,603,043...43,757,549
JBrowse link
altered epidermal growth factor/neuregulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egf epidermal growth factor ISO RGD PMID:19506583 RGD:5490965 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Egfr epidermal growth factor receptor ISO RGD PMID:20519133, PMID:19506583, PMID:20951313 RGD:5133241, RGD:5490965, RGD:5133242 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 ISO RGD PMID:19078924, PMID:21277552 RGD:4143515, RGD:5133243 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Tgfa transforming growth factor alpha ISO RGD PMID:19506583 RGD:5490965 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
altered Erk5 MAPK signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Map2k5 mitogen activated protein kinase kinase 5 ISO RGD PMID:16376520 RGD:2298532 NCBI chr 8:68,055,976...68,282,656
Ensembl chr 8:68,055,972...68,282,590
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 ISO RGD PMID:16376520 RGD:2298532 NCBI chr10:47,768,592...47,775,130
Ensembl chr10:47,766,680...47,775,055
JBrowse link
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Braf B-Raf proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425, PMID:21277552, PMID:20951313, PMID:18098337 RGD:2293882, RGD:5133243, RGD:5133242, RGD:2298531 NCBI chr 4:67,389,331...67,520,549
Ensembl chr 4:67,396,192...67,520,356
JBrowse link
G Kras KRAS proto-oncogene, GTPase TAS
ISO
RGD PMID:16112461, PMID:18772397, PMID:19506583, PMID:20951313, PMID:19078924 RGD:2306732, RGD:5490966, RGD:5490965, RGD:5133242, RGD:4143515 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 ISO RGD PMID:20951313, PMID:21277552 RGD:5133242, RGD:5133243 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase ISO RGD PMID:17126425 RGD:2293882 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
altered Hedgehog signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Boc BOC cell adhesion associated, oncogene regulated ISO RGD PMID:18772397 RGD:5490966 NCBI chr11:61,084,216...61,159,220
Ensembl chr11:61,083,757...61,158,838
JBrowse link
G Dhh desert hedgehog signaling molecule IMP RGD PMID:11118005 RGD:634737 NCBI chr 7:140,575,288...140,580,783
Ensembl chr 7:140,575,288...140,580,783
JBrowse link
G Gli1 GLI family zinc finger 1 ISO RGD PMID:21186299, PMID:18772397 RGD:5491005, RGD:5490966 NCBI chr 7:70,620,794...70,633,171
Ensembl chr 7:70,620,766...70,630,338
JBrowse link
G Gli3 GLI family zinc finger 3 ISS
ISO
RGD PMID:15328011, PMID:18772397 RGD:1303367, RGD:5490966 NCBI chr17:52,294,942...52,569,036
Ensembl chr17:52,294,942...52,569,036
JBrowse link
G Lrp2 LDL receptor related protein 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 3:55,665,153...55,822,484
Ensembl chr 3:55,665,145...55,822,551
JBrowse link
G Ptch1 patched 1 ISS RGD PMID:9422511 RGD:704355 NCBI chr17:1,032,242...1,085,885
Ensembl chr17:1,029,048...1,093,873
JBrowse link
G Shh sonic hedgehog signaling molecule ISO RGD PMID:19506583 RGD:5490965 NCBI chr 4:718,538...727,691
Ensembl chr 4:718,538...727,691
JBrowse link
G Smo smoothened, frizzled class receptor ISS RGD PMID:9422511 RGD:704355 NCBI chr 4:57,019,941...57,041,779
Ensembl chr 4:57,019,941...57,042,770
JBrowse link
altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vhl von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chr 4:145,580,869...145,587,835
Ensembl chr 4:145,580,799...145,587,845
JBrowse link
altered insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 ISO RGD PMID:9809695 RGD:2313694 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insr insulin receptor ISO RGD PMID:9809695 RGD:2313694 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
altered insulin-like growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Igf1 insulin-like growth factor 1 IEP RGD PMID:15996002 RGD:1580474 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
altered integrin mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ilk integrin-linked kinase ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Itga1 integrin subunit alpha 1 IMP RGD PMID:10536667 RGD:1302875 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itga11 integrin subunit alpha 11 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:67,566,874...67,683,973
Ensembl chr 8:67,615,635...67,683,973
JBrowse link
G Itga4 integrin subunit alpha 4 IMP
ISO
RGD PMID:11782963, PMID:18772397 RGD:1302879, RGD:5490966 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itga5 integrin subunit alpha 5 ISS RGD PMID:10536667 RGD:1302875 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itga8 integrin subunit alpha 8 IMP RGD PMID:10504498 RGD:633055 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itga9 integrin subunit alpha 9 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 8:127,271,029...127,576,709
Ensembl chr 8:127,271,289...127,572,988
JBrowse link
G Itgb1 integrin subunit beta 1 ISS RGD PMID:9633916 RGD:1302874 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
altered Jak-Stat signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 ISS RGD PMID:12032773 RGD:1357939 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jak3 Janus kinase 3 ISS RGD PMID:12032773 RGD:1357939 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668
JBrowse link
altered leptin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Insr insulin receptor IMP increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down RGD PMID:17585961 RGD:2290473 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Lep leptin TAS RGD PMID:11102451 RGD:61790 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lepr leptin receptor TAS
ISO
RGD PMID:11102451, PMID:17229951 RGD:61790, RGD:1600611 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221
JBrowse link
G Lepr_v2 leptin receptor, variant 2 ISO RGD PMID:17578380 RGD:2290292
altered melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide ISO RGD PMID:15189116 RGD:1357925 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Mc4r melanocortin 4 receptor ISS RGD PMID:15189116 RGD:1357925 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Pcsk1 proprotein convertase subtilisin/kexin type 1 ISS
ISO
RGD PMID:11874690, PMID:15189116 RGD:1357926, RGD:1357925 NCBI chr 2:91,450,162...91,497,091
Ensembl chr 2:91,450,162...91,497,091
JBrowse link
G Pomc proopiomelanocortin ISS
ISO
RGD PMID:15189116, PMID:11874690 RGD:1357925, RGD:1357926 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Sdc1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
JBrowse link
altered Notch signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll1 delta like canonical Notch ligand 1 ISS paper on the human protein which may be involved in disease RGD PMID:10079256 RGD:1304492 NCBI chr 1:57,318,621...57,326,732
Ensembl chr 1:57,318,708...57,327,379
JBrowse link
G Dll3 delta like canonical Notch ligand 3 ISS paper mentions mutations and diseases, deletion in mice RGD PMID:12141422 RGD:1304493 NCBI chr 1:85,485,875...85,493,683
Ensembl chr 1:85,485,289...85,493,685
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:10964583 RGD:1304484 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Jag2 jagged canonical Notch ligand 2 ISS RGD PMID:10079256 RGD:1304492 NCBI chr 6:137,711,144...137,733,331
Ensembl chr 6:137,711,155...137,733,026
JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:11900468 RGD:724389 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch4 notch receptor 4 ISS RGD PMID:10964583 RGD:1304484 NCBI chr20:4,329,794...4,353,868
Ensembl chr20:4,329,811...4,353,785
JBrowse link
G Numb NUMB, endocytic adaptor protein ISS RGD PMID:15492044 RGD:1334451 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345
JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:148,722,864...148,749,743
Ensembl chr 3:148,722,955...148,747,208
JBrowse link
altered Notch signaling pathway involving promoters term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 ISS RGD PMID:12548545 RGD:1334460 NCBI chr 2:95,320,147...95,322,701
Ensembl chr 2:95,320,283...95,322,696
JBrowse link
altered Notch signaling pathway involving the macromolecules modifying the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Numb NUMB, endocytic adaptor protein ISS In humans, loss of Numb regulation over Notch is involved in breast cancer. RGD PMID:15492044 RGD:1334451 NCBI chr 6:107,279,917...107,325,345
Ensembl chr 6:107,279,920...107,325,345
JBrowse link
G Pofut1 protein O-fucosyltransferase 1 ISS RGD PMID:14570055 RGD:1334453 NCBI chr 3:148,722,864...148,749,743
Ensembl chr 3:148,722,955...148,747,208
JBrowse link
G Psen2 presenilin 2 ISO C. elegans transgenics expressing human wild-type and mutant PSEN2 RGD PMID:16474849 RGD:2302525 NCBI chr13:98,513,600...98,539,347
Ensembl chr13:98,513,570...98,530,724
JBrowse link
altered Notch signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dll3 delta like canonical Notch ligand 3 ISS RGD PMID:12141422 RGD:1304493 NCBI chr 1:85,485,875...85,493,683
Ensembl chr 1:85,485,289...85,493,685
JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISS RGD PMID:15057910 RGD:1334443 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770
JBrowse link
G Notch1 notch receptor 1 ISS RGD PMID:15472075 RGD:1334450 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025
JBrowse link
G Notch3 notch receptor 3 ISS RGD PMID:14667809 RGD:1334442 NCBI chr 7:14,138,495...14,189,688
Ensembl chr 7:14,138,495...14,189,688
JBrowse link
altered p53 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ets1 ETS proto-oncogene 1, transcription factor ISO RGD PMID:22713868 RGD:8663430 NCBI chr 8:33,756,634...33,879,625
Ensembl chr 8:33,816,386...33,879,625
JBrowse link
G Mdm2 MDM2 proto-oncogene ISO RGD PMID:19165225, PMID:23262034 RGD:2316186, RGD:8663434 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mdm4 MDM4 regulator of p53 ISO RGD PMID:23262034 RGD:8663434 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO RGD PMID:23263379 RGD:8663431 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Nfya nuclear transcription factor Y subunit alpha ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 9:14,551,752...14,577,002
Ensembl chr 9:14,551,758...14,576,967
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 7:27,081,667...27,097,481
Ensembl chr 7:27,081,667...27,097,479
JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 5:139,687,442...139,760,154
Ensembl chr 5:139,687,448...139,749,050
JBrowse link
G Pin1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:22713868 RGD:8663430 NCBI chr 8:21,669,236...21,680,615
Ensembl chr 8:21,669,236...21,680,615
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Tp53 tumor protein p53 ISO DNA:mutations:exon RGD PMID:19165225, PMID:23759327, PMID:22713868, PMID:23263379, PMID:18772397, PMID:20951313, PMID:19078924 RGD:2316186, RGD:8693397, RGD:8663430, RGD:8663431, RGD:5490966, RGD:5133242, RGD:4143515 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 ISO RGD PMID:23263379, PMID:22713868 RGD:8663431, RGD:8663430 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:22713868 RGD:8663430 NCBI chr 7:139,344,452...139,394,138
Ensembl chr 7:139,342,063...139,394,166
JBrowse link
altered phosphatidylinositol 3-kinase signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:23759327 RGD:8693397 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:23759327 RGD:8693397 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
altered phosphatidylinositol 3-kinase-Akt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 ISO RGD PMID:18955974, PMID:21277552 RGD:2313763, RGD:5133243 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:18955974, PMID:15166380, PMID:19506583 RGD:2313763, RGD:2313408, RGD:5490965 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 ISO RGD PMID:18955974 RGD:2313763 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO RGD PMID:18955974, PMID:21277552, PMID:20951313, PMID:19078924 RGD:2313763, RGD:5133243, RGD:5133242, RGD:4143515 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:18955974, PMID:19506583, PMID:20951313, PMID:19078924, PMID:18008377 RGD:2313763, RGD:5490965, RGD:5133242, RGD:4143515, RGD:2326139 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
altered Reelin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dab1 DAB adaptor protein 1 TAS RGD PMID:12670697 RGD:727518 NCBI chr 5:123,154,360...124,279,170
Ensembl chr 5:123,905,166...124,280,115
JBrowse link
G Fyn FYN proto-oncogene, Src family tyrosine kinase ISO RGD PMID:12778121 RGD:2324970 NCBI chr20:44,436,354...44,630,316
Ensembl chr20:44,436,403...44,630,317
JBrowse link
G Itga3 integrin subunit alpha 3 ISO RGD PMID:15583703 RGD:2325851 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itgb1 integrin subunit beta 1 ISO RGD PMID:15583703 RGD:2325851 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Lrp8 LDL receptor related protein 8 ISO RGD PMID:19846452 RGD:2324974 NCBI chr 5:127,404,348...127,476,636
Ensembl chr 5:127,404,450...127,476,641
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 ISO RGD PMID:17330141 RGD:4107040 NCBI chr10:61,456,144...61,577,412
Ensembl chr10:61,456,145...61,577,412
JBrowse link
G Pafah1b2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 8:50,256,969...50,310,043
Ensembl chr 8:50,259,248...50,277,797
JBrowse link
G Pafah1b3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 ISO RGD PMID:17330141 RGD:4107040 NCBI chr 1:82,163,733...82,166,259
Ensembl chr 1:82,163,595...82,166,363
JBrowse link
G Reln reelin TAS RGD PMID:12670697 RGD:727518 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO RGD PMID:18237558 RGD:2325284 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Vldlr very low density lipoprotein receptor ISS RGD PMID:12764038 RGD:1358468 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
altered scatter factor/hepatocyte growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:20519133, PMID:19506583, PMID:21277552, PMID:20951313 RGD:5133241, RGD:5490965, RGD:5133243, RGD:5133242 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
altered transforming growth factor-beta Smad dependent signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad2 SMAD family member 2 ISO RGD PMID:17613544, PMID:18662538 RGD:2306282, RGD:2308865 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:17613544, PMID:18772397 RGD:2306282, RGD:5490966 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 ISO RGD PMID:17613544, PMID:19506583, PMID:18772397, PMID:18662538 RGD:2306282, RGD:5490965, RGD:5490966, RGD:2308865 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Smad7 SMAD family member 7 ISO RGD PMID:18662538 RGD:2308865 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Tgfb1 transforming growth factor, beta 1 ISO RGD PMID:18313409, PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 ISO RGD PMID:18313409, PMID:17613544 RGD:2299005, RGD:2306282 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 ISO RGD PMID:18313409, PMID:19506583, PMID:18772397, PMID:17613544, PMID:18662538 RGD:2299005, RGD:5490965, RGD:5490966, RGD:2306282, RGD:2308865 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flt4 Fms related receptor tyrosine kinase 4 ISS RGD PMID:15563310 RGD:1334463 NCBI chr10:35,078,782...35,120,296
Ensembl chr10:35,078,726...35,121,599
JBrowse link
G Kdr kinase insert domain receptor IMP RGD PMID:18221855 RGD:2292019 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Vegfa vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
altered visual phototransduction pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:20212494 RGD:8547536 NCBI chr14:38,155,771...38,171,107
Ensembl chr14:38,155,759...38,171,010
JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 ISO RGD PMID:20212494 RGD:8547536 NCBI chr19:10,142,440...10,206,618
Ensembl chr19:10,142,496...10,206,681
JBrowse link
G Guca1b guanylate cyclase activator 1B ISO RGD PMID:20212494 RGD:8547536 NCBI chr 9:15,621,083...15,629,017
Ensembl chr 9:15,621,083...15,629,017
JBrowse link
G Pde6a phosphodiesterase 6A ISO RGD PMID:20212494 RGD:8547536 NCBI chr18:56,544,652...56,617,480
Ensembl chr18:56,544,652...56,617,480
JBrowse link
G Pde6b phosphodiesterase 6B ISO RGD PMID:20212494 RGD:8547536 NCBI chr14:2,328,690...2,371,913
Ensembl chr14:2,328,750...2,371,883
JBrowse link
G Pde6g phosphodiesterase 6G ISO RGD PMID:20212494 RGD:8547536 NCBI chr10:109,620,499...109,625,214
Ensembl chr10:109,620,980...109,622,745
JBrowse link
G Rho rhodopsin ISO RGD PMID:20212494 RGD:8547536 NCBI chr 4:147,832,136...147,837,298
Ensembl chr 4:147,832,136...147,837,298
JBrowse link
G Sag S-antigen visual arrestin ISO RGD PMID:20212494 RGD:8547536 NCBI chr 9:94,926,901...94,972,162
Ensembl chr 9:94,928,489...94,972,027
JBrowse link
altered Wnt signaling, canonical pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO RGD PMID:18432252 RGD:2293188 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Axin1 axin 1 ISO RGD PMID:18432252 RGD:2293188
G Axin2 axin 2 ISO RGD PMID:18432252 RGD:2293188 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Ctnnb1 catenin beta 1 ISO RGD PMID:18432252, PMID:19078924 RGD:2293188, RGD:4143515 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Lrp5 LDL receptor related protein 5 ISO RGD PMID:18432252 RGD:2293188 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO RGD PMID:18772397 RGD:5490966 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514
JBrowse link
G Wnt9a Wnt family member 9A ISO RGD PMID:18772397 RGD:5490966 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393
JBrowse link

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.