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Pathways

PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).

Term:altered regulatory pathway
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Accession:PW:0000263 term browser browse the term
Definition:Those regulatory pathways that deviate from what their normal course should be. Aberrant regulatory pathways, alone or in combination with other pathways underlie many conditions, disorders and/or diseases.


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altered androgen signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor ISO RGD PMID:18008377 PMID:23759327 RGD:2326139 RGD:8693397 NCBI chr  X:57,380,587...57,553,613
Ensembl chr  X:57,380,611...57,546,776
JBrowse link
G NCOA2 nuclear receptor coactivator 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr 8:65,855,232...66,151,733
Ensembl chr 8:65,855,235...66,040,947
JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:23759327 RGD:8693397 NCBI chr11:119,675,363...119,917,059
Ensembl chr11:119,676,345...119,917,000
JBrowse link
altered citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FH fumarate hydratase ISO RGD PMID:17211469 RGD:6907135 NCBI chr25:78,576,931...78,599,998
Ensembl chr25:78,575,300...78,599,972
JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B ISO RGD PMID:21771581 RGD:6907134 NCBI chr20:115,537,880...115,571,150
Ensembl chr20:115,538,026...115,571,142
JBrowse link
G SDHD succinate dehydrogenase complex subunit D ISO RGD PMID:21771581 RGD:6907134 NCBI chr 1:103,443,666...103,452,681 JBrowse link
altered clathrin-dependent synaptic vesicle endocytosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJC6 DnaJ heat shock protein family (Hsp40) member C6 ISO RGD PMID:25302295 RGD:10450553 NCBI chr20:67,661,187...67,824,822
Ensembl chr20:67,660,680...67,809,086
JBrowse link
G SYNJ1 synaptojanin 1 ISO RGD PMID:25302295 RGD:10450553 NCBI chr 2:59,421,561...59,523,076
Ensembl chr 2:59,422,110...59,523,176
JBrowse link
altered DNA modification pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MBD4 methyl-CpG binding domain 4, DNA glycosylase ISO in silico assessment of loss of DNA-protein interactions and observed enhancement of DNA repair capacity (DRC) in the context of nucleotide excision repair (NER) pathway for SNP RGD PMID:24004570 RGD:9588971 NCBI chr22:51,616,840...51,626,232
Ensembl chr22:51,616,803...51,626,224
JBrowse link
altered energy homeostasis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LEP leptin ISO RGD PMID:11102451 PMID:15703762 RGD:1357910 RGD:61790 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220
JBrowse link
G LEPR leptin receptor ISO RGD PMID:11102451 PMID:15703762 RGD:1357910 RGD:61790 NCBI chr20:67,454,205...67,567,524
Ensembl chr20:67,454,334...67,524,229
JBrowse link
G MC4R melanocortin 4 receptor ISO RGD PMID:15189116 RGD:1357925 NCBI chr18:19,380,054...19,386,412
Ensembl chr18:19,380,849...19,381,847
JBrowse link
G PCSK1 proprotein convertase subtilisin/kexin type 1 ISO RGD PMID:11874690 RGD:1357926 NCBI chr 4:90,246,413...90,289,148
Ensembl chr 4:90,248,598...90,289,089
JBrowse link
G POMC proopiomelanocortin ISO RGD PMID:11874690 RGD:1357926 NCBI chr14:82,491,296...82,499,289
Ensembl chr14:82,494,323...82,499,447
JBrowse link
altered G1/S transition pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN2A cyclin dependent kinase inhibitor 2A ISO RGD PMID:18772397 RGD:5490966
altered hypoxia inducible factor pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VHL von Hippel-Lindau tumor suppressor ISO RGD PMID:22035299 RGD:6907133 NCBI chr22:46,184,621...46,203,065
Ensembl chr22:46,184,756...46,204,428
JBrowse link
altered insulin responsive facilitative sugar transporter mediated glucose transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT2 AKT serine/threonine kinase 2 ISO RGD PMID:21979934 RGD:7248543 NCBI chr 6:34,688,585...34,740,458
Ensembl chr 6:34,690,462...34,720,781
JBrowse link
G TBC1D4 TBC1 domain family member 4 ISO RGD PMID:19470471 RGD:7248544 NCBI chr 3:54,384,597...54,588,842
Ensembl chr 3:54,386,342...54,464,531
JBrowse link
altered insulin secretion pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC8 ATP binding cassette subfamily C member 8 ISO DNA:missense mutation::A1369S RGD PMID:17259403 RGD:2313628 NCBI chr 1:47,494,861...47,578,818
Ensembl chr 1:47,494,959...47,578,882
JBrowse link
G KCNJ11 potassium inwardly rectifying channel subfamily J member 11 ISO polymorphisms in the gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:missense mutation::p.E23K (human)
RGD PMID:15565284 PMID:17259403 RGD:2313610 RGD:2313628 NCBI chr 1:47,582,519...47,586,466
Ensembl chr 1:47,583,629...47,584,801
JBrowse link
altered insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin ISO RGD PMID:9809695 RGD:2313694 NCBI chr 1:1,965,128...1,969,090 JBrowse link
G INSR insulin receptor ISO RGD PMID:9809695 RGD:2313694 NCBI chr 6:6,625,951...6,803,610
Ensembl chr 6:6,630,777...6,803,592
JBrowse link
altered leptin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INSR insulin receptor ISO increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down RGD PMID:17585961 RGD:2290473 NCBI chr 6:6,625,951...6,803,610
Ensembl chr 6:6,630,777...6,803,592
JBrowse link
G LEP leptin ISO RGD PMID:11102451 PMID:15703762 RGD:1357910 RGD:61790 NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220
JBrowse link
G LEPR leptin receptor ISO RGD PMID:11102451 PMID:15703762 PMID:17229951 RGD:1357910 RGD:1600611 RGD:61790 NCBI chr20:67,454,205...67,567,524
Ensembl chr20:67,454,334...67,524,229
JBrowse link
altered melanocortin system pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGRP agouti related neuropeptide ISO RGD PMID:15189116 RGD:1357925 NCBI chr 5:59,972,728...59,974,728
Ensembl chr 5:59,973,922...59,974,660
JBrowse link
G MC4R melanocortin 4 receptor ISO RGD PMID:15189116 RGD:1357925 NCBI chr18:19,380,054...19,386,412
Ensembl chr18:19,380,849...19,381,847
JBrowse link
G PCSK1 proprotein convertase subtilisin/kexin type 1 ISO RGD PMID:11874690 PMID:15189116 RGD:1357925 RGD:1357926 NCBI chr 4:90,246,413...90,289,148
Ensembl chr 4:90,248,598...90,289,089
JBrowse link
G POMC proopiomelanocortin ISO RGD PMID:11874690 PMID:15189116 RGD:1357925 RGD:1357926 NCBI chr14:82,491,296...82,499,289
Ensembl chr14:82,494,323...82,499,447
JBrowse link
G SDC1 syndecan 1 ISO RGD PMID:15189116 RGD:1357925 NCBI chr14:87,499,732...87,523,122
Ensembl chr14:87,499,574...87,525,026
JBrowse link
altered mismatch repair pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLH1 mutL homolog 1 ISO RGD PMID:11900875 PMID:19078924 RGD:2306714 RGD:4143515 NCBI chr15:2,364,537...2,418,379
Ensembl chr15:2,364,738...2,418,393
JBrowse link
G MSH2 mutS homolog 2 ISO RGD PMID:11900875 RGD:2306714 NCBI chr14:59,730,101...59,802,857
Ensembl chr14:59,729,789...59,802,819
JBrowse link
G MSH6 mutS homolog 6 ISO RGD PMID:11900875 PMID:19078924 RGD:2306714 RGD:4143515 NCBI chr14:59,375,602...59,400,252
Ensembl chr14:59,375,691...59,400,174
JBrowse link
G PMS1 PMS1 homolog 1, mismatch repair system component ISO RGD PMID:11900875 RGD:2306714 NCBI chr10:75,305,129...75,392,193
Ensembl chr10:75,311,887...75,392,590
JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component ISO RGD PMID:11900875 RGD:2306714 NCBI chr28:15,174,359...15,209,962
Ensembl chr28:15,172,100...15,209,852
JBrowse link
altered mitochondrial autophagy pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PINK1 PTEN induced kinase 1 ISO RGD PMID:24735649 RGD:10450527 NCBI chr20:111,902,135...111,919,082
Ensembl chr20:111,902,765...111,919,069
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:24735649 RGD:10450527 NCBI chr13:88,856,056...90,329,379 JBrowse link
altered nucleotide excision repair pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDB1 damage specific DNA binding protein 1 ISO RGD PMID:22824526 RGD:7246919 NCBI chr 1:12,508,712...12,543,127
Ensembl chr 1:12,508,443...12,544,913
JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit ISO RGD PMID:22824526 RGD:7246919 NCBI chr 6:38,804,296...38,823,229
Ensembl chr 6:38,801,423...38,823,073
JBrowse link
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO RGD PMID:22824526 RGD:7246919 NCBI chr10:2,926,410...2,963,802
Ensembl chr10:2,926,350...2,963,823
JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit ISO in silico assessment of alteration of DNA-protein, protein-protein interactions and observed reduction of DNA repair capacity in the context of nucleotide excision repair pathway for SNP RGD PMID:22824526 PMID:24004570 RGD:7246919 RGD:9588971 NCBI chr 5:13,378,282...13,410,307
Ensembl chr 5:13,378,401...13,406,541
JBrowse link
G ERCC5 ERCC excision repair 5, endonuclease ISO RGD PMID:22824526 RGD:7246919 NCBI chr 3:81,406,103...81,441,422
Ensembl chr 3:81,405,872...81,436,040
JBrowse link
G ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit ISO RGD PMID:22824526 RGD:7246919 NCBI chr 4:57,048,262...57,128,338
Ensembl chr 4:57,045,018...57,128,307
JBrowse link
G XPA XPA, DNA damage recognition and repair factor ISO RGD PMID:22824526 RGD:7246919 NCBI chr12:41,711,872...41,735,024
Ensembl chr12:41,711,943...41,725,698
JBrowse link
G XPC XPC complex subunit, DNA damage recognition and repair factor ISO RGD PMID:22824526 RGD:7246919 NCBI chr22:50,088,019...50,121,584
Ensembl chr22:50,085,353...50,121,542
JBrowse link
altered p53 signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ETS1 ETS proto-oncogene 1, transcription factor ISO RGD PMID:22713868 RGD:8663430 NCBI chr 1:119,588,476...119,736,623
Ensembl chr 1:119,588,448...119,652,299
JBrowse link
G MDM2 MDM2 proto-oncogene ISO RGD PMID:19165225 PMID:23262034 RGD:2316186 RGD:8663434 NCBI chr11:64,434,203...64,465,490
Ensembl chr11:64,434,261...64,469,890
JBrowse link
G MDM4 MDM4 regulator of p53 ISO RGD PMID:23262034 RGD:8663434 NCBI chr25:24,797,238...24,843,034
Ensembl chr25:24,797,278...24,833,485
JBrowse link
G MRE11 MRE11 double strand break repair nuclease ISO RGD PMID:23263379 RGD:8663431 NCBI chr 1:85,615,448...85,694,247
Ensembl chr 1:85,610,819...85,694,269
JBrowse link
G NFYA nuclear transcription factor Y subunit alpha ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chr17:31,057,059...31,084,036
Ensembl chr17:31,059,630...31,077,926
JBrowse link
G NFYB nuclear transcription factor Y subunit beta ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chr11:99,320,263...99,341,289
Ensembl chr11:99,319,390...99,329,726
JBrowse link
G NFYC nuclear transcription factor Y subunit gamma ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chr20:92,152,410...92,232,501
Ensembl chr20:92,152,141...92,189,107
JBrowse link
G PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 ISO RGD PMID:22713868 RGD:8663430 NCBI chr 6:8,920,860...8,935,943
Ensembl chr 6:8,920,785...8,936,033
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chr19:24,364,725...24,439,851
Ensembl chr19:24,364,911...24,440,014
JBrowse link
G TP53 tumor protein p53 ISO RGD PMID:18772397 PMID:19078924 PMID:19165225 PMID:20951313 PMID:22713868 More... RGD:2316186 RGD:4143515 RGD:5133242 RGD:5490966 RGD:8663430 RGD:8663431 RGD:8693397 NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223
JBrowse link
G TP63 tumor protein p63 ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chr15:83,861,489...84,126,675 JBrowse link
G TP73 tumor protein p73 ISO RGD PMID:22713868 PMID:23263379 RGD:8663430 RGD:8663431 NCBI chr20:127,958,002...128,035,792
Ensembl chr20:127,958,809...128,013,691
JBrowse link
G VDR vitamin D receptor ISO RGD PMID:22713868 RGD:8663430 NCBI chr11:44,062,198...44,126,295
Ensembl chr11:44,065,457...44,166,684
JBrowse link
altered retinoid cycle metabolic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA4 ATP binding cassette subfamily A member 4 ISO RGD PMID:20212494 RGD:8547536 NCBI chr20:39,140,288...39,271,169
Ensembl chr20:39,140,922...39,267,638
JBrowse link
G LRAT lecithin retinol acyltransferase ISO RGD PMID:20212494 RGD:8547536 NCBI chr 7:101,297,114...101,304,675
Ensembl chr 7:101,297,691...101,302,520
JBrowse link
G RBP3 retinol binding protein 3 ISO RGD PMID:20212494 RGD:8547536 NCBI chr 9:44,111,494...44,124,352
Ensembl chr 9:44,114,562...44,123,932
JBrowse link
G RDH12 retinol dehydrogenase 12 ISO RGD PMID:20212494 RGD:8547536 NCBI chr24:44,957,854...44,971,855
Ensembl chr24:44,959,921...44,971,836
JBrowse link
G RLBP1 retinaldehyde binding protein 1 ISO RGD PMID:20212494 RGD:8547536 NCBI chr29:7,756,742...7,769,061
Ensembl chr29:7,757,158...7,765,777
JBrowse link
G RPE65 retinoid isomerohydrolase RPE65 ISO RGD PMID:20212494 RGD:8547536 NCBI chr20:64,662,777...64,684,178
Ensembl chr20:64,664,358...64,683,211
JBrowse link
altered retromer-mediated pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 ISO RGD PMID:25701813 RGD:10450845 NCBI chr15:57,727,636...57,846,469
Ensembl chr15:57,726,576...57,846,478
JBrowse link
G VPS35 VPS35 retromer complex component ISO RGD PMID:25619244 PMID:25701813 RGD:10450542 RGD:10450845 NCBI chr 5:32,509,037...32,539,371
Ensembl chr 5:32,508,580...32,539,343
JBrowse link
altered reverse cholesterol transport pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 ISO RGD PMID:11086027 RGD:1600951 NCBI chr12:34,587,123...34,734,936
Ensembl chr12:34,587,118...34,731,642
JBrowse link
altered surfactant homeostasis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA3 ATP binding cassette subfamily A member 3 ISO RGD PMID:15985750 RGD:1549859 NCBI chr 5:2,171,487...2,218,851 JBrowse link
altered SWI/SNF family mediated chromatin remodeling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTL6A actin like 6A ISO RGD PMID:23355908 RGD:8694154 NCBI chr15:9,838,609...9,863,439
Ensembl chr15:9,837,274...9,863,430
JBrowse link
G ARID1A AT-rich interaction domain 1A ISO RGD PMID:23355908 RGD:8694154 NCBI chr20:105,981,549...106,066,093
Ensembl chr20:105,981,290...106,065,672
JBrowse link
G ARID1B AT-rich interaction domain 1B ISO RGD PMID:23355908 RGD:8694154 NCBI chr13:84,351,298...84,799,691 JBrowse link
G PBRM1 polybromo 1 ISO RGD PMID:23355908 RGD:8694154 NCBI chr22:13,914,023...14,059,221
Ensembl chr22:13,913,285...14,055,254
JBrowse link
G SMARCA4 SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4 ISO RGD PMID:23355908 RGD:8694154 NCBI chr 6:9,943,162...10,044,476 JBrowse link
altered ubiquitin/proteasome degradation pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UBE2D3 ubiquitin conjugating enzyme E2 D3 ISO RGD PMID:11020223 RGD:1302873 NCBI chr 7:50,895,052...50,927,726 JBrowse link
G UBE2D4 ubiquitin conjugating enzyme E2 D4 ISO RGD PMID:11020223 RGD:1302873 NCBI chr21:14,636,512...14,665,170
Ensembl chr21:14,634,384...14,664,909
JBrowse link
G UBE2G1 ubiquitin conjugating enzyme E2 G1 ISO RGD PMID:11020223 RGD:1302873 NCBI chr16:3,743,036...3,845,567
Ensembl chr16:3,742,881...3,845,522
JBrowse link
G UBE2I ubiquitin conjugating enzyme E2 I ISO RGD PMID:11020223 RGD:1302873 NCBI chr 5:1,203,513...1,216,662
Ensembl chr 5:1,200,018...1,216,741
JBrowse link
G UBE2N ubiquitin conjugating enzyme E2 N ISO RGD PMID:11020223 RGD:1302873 NCBI chr11:88,810,505...88,842,895 JBrowse link
altered vascular endothelial growth factor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT4 fms related receptor tyrosine kinase 4 ISO RGD PMID:15563310 RGD:1334463 NCBI chr23:82,328,257...82,373,785
Ensembl chr23:82,328,258...82,357,044
JBrowse link
altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KDR kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr17:28,377,959...28,394,508 JBrowse link
altered vascular endothelial growth factor signaling pathway involving the main players term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLT4 fms related receptor tyrosine kinase 4 ISO RGD PMID:15563310 RGD:1334463 NCBI chr23:82,328,257...82,373,785
Ensembl chr23:82,328,258...82,357,044
JBrowse link
G KDR kinase insert domain receptor ISO RGD PMID:18221855 RGD:2292019 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771
JBrowse link
G VEGFA vascular endothelial growth factor A ISO RGD PMID:18221855 RGD:2292019 NCBI chr17:28,377,959...28,394,508 JBrowse link

Term paths to the root