PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html ).
Term: altered regulatory pathway
Accession: PW:0000263
browse the term
Definition: Those regulatory pathways that deviate from what their normal course should be. Aberrant regulatory pathways, alone or in combination with other pathways underlie many conditions, disorders and/or diseases.
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Ar
androgen receptor
ISO
RGD
PMID:18008377 PMID:23759327
RGD:2326139 RGD:8693397
NCBI chrNW_004955475:7,013,960...7,192,473
Ensembl chrNW_004955475:7,013,960...7,186,069
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Ncoa2
nuclear receptor coactivator 2
ISO
RGD
PMID:23759327
RGD:8693397
NCBI chrNW_004955444:9,313,748...9,587,109
Ensembl chrNW_004955444:9,313,447...9,584,913
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Ncor2
nuclear receptor corepressor 2
ISO
RGD
PMID:23759327
RGD:8693397
NCBI chrNW_004955482:4,927,482...5,031,848
Ensembl chrNW_004955482:4,942,221...5,031,904
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Fh
fumarate hydratase
ISO
RGD
PMID:17211469
RGD:6907135
NCBI chrNW_004955406:10,535,801...10,558,649
Ensembl chrNW_004955406:10,535,323...10,561,627
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Sdhb
succinate dehydrogenase complex iron sulfur subunit B
ISO
RGD
PMID:21771581
RGD:6907134
NCBI chrNW_004955527:1,769,280...1,792,496
Ensembl chrNW_004955527:1,768,940...1,792,361
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Sdhd
succinate dehydrogenase complex subunit D
ISO
RGD
PMID:21771581
RGD:6907134
NCBI chrNW_004955412:13,768,501...13,778,944
Ensembl chrNW_004955412:13,768,501...13,778,932
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Dnajc6
DnaJ heat shock protein family (Hsp40) member C6
ISO
RGD
PMID:25302295
RGD:10450553
NCBI chrNW_004955423:25,269,459...25,382,664
Ensembl chrNW_004955423:25,269,466...25,377,641
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Synj1
synaptojanin 1
ISO
RGD
PMID:25302295
RGD:10450553
NCBI chrNW_004955407:32,094,076...32,175,676
Ensembl chrNW_004955407:32,093,479...32,175,795
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Mbd4
methyl-CpG binding domain 4, DNA glycosylase
ISO
in silico assessment of loss of DNA-protein interactions and observed enhancement of DNA repair capacity (DRC) in the context of nucleotide excision repair (NER) pathway for SNP
RGD
PMID:24004570
RGD:9588971
NCBI chrNW_004955429:17,858,656...17,868,111
Ensembl chrNW_004955429:17,858,937...17,869,262
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Lep
leptin
ISO
RGD
PMID:11102451 PMID:15703762
RGD:1357910 RGD:61790
NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472
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Lepr
leptin receptor
ISO
RGD
PMID:11102451 PMID:15703762
RGD:1357910 RGD:61790
NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407
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Mc4r
melanocortin 4 receptor
ISO
RGD
PMID:15189116
RGD:1357925
NCBI chrNW_004955402:44,453,973...44,456,689
Ensembl chrNW_004955402:44,455,294...44,456,292
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Pcsk1
proprotein convertase subtilisin/kexin type 1
ISO
RGD
PMID:11874690
RGD:1357926
NCBI chrNW_004955418:16,181,809...16,224,274
Ensembl chrNW_004955418:16,181,771...16,224,603
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Pomc
proopiomelanocortin
ISO
RGD
PMID:11874690
RGD:1357926
NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386
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Vhl
von Hippel-Lindau tumor suppressor
ISO
RGD
PMID:22035299
RGD:6907133
NCBI chrNW_004955561:1,573,525...1,578,295
Ensembl chrNW_004955561:1,573,525...1,580,511
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Akt2
AKT serine/threonine kinase 2
ISO
RGD
PMID:21979934
RGD:7248543
NCBI chrNW_004955578:950,258...1,004,438
Ensembl chrNW_004955578:967,593...1,004,438
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Tbc1d4
TBC1 domain family member 4
ISO
RGD
PMID:19470471
RGD:7248544
NCBI chrNW_004955404:31,516,727...31,691,414
Ensembl chrNW_004955404:31,622,102...31,691,517
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Abcc8
ATP binding cassette subfamily C member 8
ISO
DNA:missense mutation::A1369S
RGD
PMID:17259403
RGD:2313628
NCBI chrNW_004955414:32,216,243...32,289,028
Ensembl chrNW_004955414:32,216,196...32,289,053
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Kcnj11
potassium inwardly rectifying channel subfamily J member 11
ISO
DNA:missense mutation::p.E23K (human) polymorphisms in the gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
RGD
PMID:15565284 PMID:17259403
RGD:2313610 RGD:2313628
NCBI chrNW_004955414:32,209,426...32,212,424
Ensembl chrNW_004955414:32,210,545...32,211,717
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Ins
insulin
ISO
RGD
PMID:9809695
RGD:2313694
NCBI chrNW_004955422:13,909,408...13,910,419
Ensembl chrNW_004955422:13,909,407...13,910,419
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Insr
insulin receptor
ISO
RGD
PMID:9809695
RGD:2313694
NCBI chrNW_004955563:1,867,400...2,011,845
Ensembl chrNW_004955563:1,867,400...2,009,149
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Insr
insulin receptor
ISO
increased basal hypothalamic leptin signaling without changes in leptin receptor expression after antisense-mediated hypothalamus-specific Insr knock-down
RGD
PMID:17585961
RGD:2290473
NCBI chrNW_004955563:1,867,400...2,011,845
Ensembl chrNW_004955563:1,867,400...2,009,149
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Lep
leptin
ISO
RGD
PMID:11102451 PMID:15703762
RGD:1357910 RGD:61790
NCBI chrNW_004955479:9,266,604...9,276,568
Ensembl chrNW_004955479:9,274,516...9,279,472
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Lepr
leptin receptor
ISO
RGD
PMID:11102451 PMID:15703762 PMID:17229951
RGD:1357910 RGD:1600611 RGD:61790
NCBI chrNW_004955423:25,108,897...25,185,315
Ensembl chrNW_004955423:25,111,266...25,185,407
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Agrp
agouti related neuropeptide
ISO
RGD
PMID:15189116
RGD:1357925
NCBI chrNW_004955484:9,165,120...9,166,789
Ensembl chrNW_004955484:9,165,120...9,166,789
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Mc4r
melanocortin 4 receptor
ISO
RGD
PMID:15189116
RGD:1357925
NCBI chrNW_004955402:44,453,973...44,456,689
Ensembl chrNW_004955402:44,455,294...44,456,292
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Pcsk1
proprotein convertase subtilisin/kexin type 1
ISO
RGD
PMID:11874690 PMID:15189116
RGD:1357925 RGD:1357926
NCBI chrNW_004955418:16,181,809...16,224,274
Ensembl chrNW_004955418:16,181,771...16,224,603
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Pomc
proopiomelanocortin
ISO
RGD
PMID:11874690 PMID:15189116
RGD:1357925 RGD:1357926
NCBI chrNW_004955469:7,217,233...7,220,401
Ensembl chrNW_004955469:7,217,363...7,220,386
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Sdc1
syndecan 1
ISO
RGD
PMID:15189116
RGD:1357925
NCBI chrNW_004955469:2,762,696...2,773,697
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Mlh1
mutL homolog 1
ISO
RGD
PMID:11900875 PMID:19078924
RGD:2306714 RGD:4143515
NCBI chrNW_004955421:3,890,291...3,936,892
Ensembl chrNW_004955421:3,890,306...3,936,526
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Msh2
mutS homolog 2
ISO
RGD
PMID:11900875
RGD:2306714
NCBI chrNW_004955441:14,188,315...14,247,608
Ensembl chrNW_004955441:14,187,805...14,247,698
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Msh6
mutS homolog 6
ISO
RGD
PMID:11900875 PMID:19078924
RGD:2306714 RGD:4143515
NCBI chrNW_004955441:14,451,207...14,471,316
Ensembl chrNW_004955441:14,451,307...14,471,227
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Pms1
PMS1 homolog 1, mismatch repair system component
ISO
RGD
PMID:11900875
RGD:2306714
NCBI chrNW_004955403:9,021,488...9,100,442
Ensembl chrNW_004955403:9,022,078...9,100,442
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Pms2
PMS1 homolog 2, mismatch repair system component
ISO
RGD
PMID:11900875
RGD:2306714
NCBI chrNW_004955460:13,762,854...13,791,462
Ensembl chrNW_004955460:13,762,955...13,790,070
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Pink1
PTEN induced kinase 1
ISO
RGD
PMID:24735649
RGD:10450527
NCBI chrNW_004955452:1,171,115...1,186,338
Ensembl chrNW_004955452:1,171,205...1,185,125
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Prkn
parkin RBR E3 ubiquitin protein ligase
ISO
RGD
PMID:24735649
RGD:10450527
NCBI chrNW_004955439:18,664,230...19,953,358
Ensembl chrNW_004955439:18,664,379...19,951,152
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Ddb1
damage specific DNA binding protein 1
ISO
RGD
PMID:22824526
RGD:7246919
NCBI chrNW_004955511:6,209,777...6,233,594
Ensembl chrNW_004955511:6,209,777...6,233,594
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Ercc2
ERCC excision repair 2, TFIIH core complex helicase subunit
ISO
RGD
PMID:22824526
RGD:7246919
NCBI chrNW_004955555:2,355,005...2,369,599
Ensembl chrNW_004955555:2,355,005...2,369,599
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Ercc3
ERCC excision repair 3, TFIIH core complex helicase subunit
ISO
RGD
PMID:22824526
RGD:7246919
NCBI chrNW_004955459:3,210,936...3,238,401
Ensembl chrNW_004955459:3,210,479...3,242,576
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Ercc4
ERCC excision repair 4, endonuclease catalytic subunit
ISO
in silico assessment of alteration of DNA-protein, protein-protein interactions and observed reduction of DNA repair capacity in the context of nucleotide excision repair pathway for SNP
RGD
PMID:22824526 PMID:24004570
RGD:7246919 RGD:9588971
NCBI chrNW_004955442:4,833,453...4,861,201
Ensembl chrNW_004955442:4,831,721...4,861,122
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Ercc5
ERCC excision repair 5, endonuclease
ISO
RGD
PMID:22824526
RGD:7246919
NCBI chrNW_004955404:8,294,506...8,321,505
Ensembl chrNW_004955404:8,294,346...8,321,112
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
ISO
RGD
PMID:22824526
RGD:7246919
NCBI chrNW_004955556:745,175...812,215
Ensembl chrNW_004955556:748,231...813,133
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Xpa
XPA, DNA damage recognition and repair factor
ISO
RGD
PMID:22824526
RGD:7246919
NCBI chrNW_004955419:27,751,042...27,774,917
Ensembl chrNW_004955419:27,751,043...27,774,917
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Xpc
XPC complex subunit, DNA damage recognition and repair factor
ISO
RGD
PMID:22824526
RGD:7246919
NCBI chrNW_004955429:16,935,901...16,968,285
Ensembl chrNW_004955429:16,935,901...16,955,845
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Ets1
ETS proto-oncogene 1, transcription factor
ISO
RGD
PMID:22713868
RGD:8663430
NCBI chrNW_004955412:29,433,730...29,602,389
Ensembl chrNW_004955412:29,432,482...29,545,580
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Mdm2
MDM2 proto-oncogene
ISO
RGD
PMID:19165225 PMID:23262034
RGD:2316186 RGD:8663434
NCBI chrNW_004955458:15,264,028...15,287,290
Ensembl chrNW_004955458:15,263,739...15,286,808
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Mdm4
MDM4 regulator of p53
ISO
RGD
PMID:23262034
RGD:8663434
NCBI chrNW_004955406:40,346,617...40,387,977
Ensembl chrNW_004955406:40,346,588...40,387,977
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Nfya
nuclear transcription factor Y subunit alpha
ISO
RGD
PMID:22713868 PMID:23263379
RGD:8663430 RGD:8663431
NCBI chrNW_004955437:7,745,182...7,770,348
Ensembl chrNW_004955437:7,744,633...7,771,035
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Nfyb
nuclear transcription factor Y subunit beta
ISO
RGD
PMID:22713868 PMID:23263379
RGD:8663430 RGD:8663431
NCBI chrNW_004955405:38,773,690...38,789,534
Ensembl chrNW_004955405:38,771,837...38,789,536
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Nfyc
nuclear transcription factor Y subunit gamma
ISO
RGD
PMID:22713868 PMID:23263379
RGD:8663430 RGD:8663431
NCBI chrNW_004955537:544,534...611,459
Ensembl chrNW_004955537:559,261...613,369
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Pin1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
ISO
RGD
PMID:22713868
RGD:8663430
NCBI chrNW_004955495:1,250,557...1,261,617
Ensembl chrNW_004955495:1,250,453...1,266,235
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Srebf2
sterol regulatory element binding transcription factor 2
ISO
RGD
PMID:22713868 PMID:23263379
RGD:8663430 RGD:8663431
NCBI chrNW_004955413:27,271,717...27,326,655
Ensembl chrNW_004955413:27,271,953...27,326,759
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Tp53
tumor protein p53
ISO
RGD
PMID:18772397 PMID:19078924 PMID:19165225 PMID:20951313 PMID:22713868 PMID:23263379 PMID:23759327 More...
RGD:2316186 RGD:4143515 RGD:5133242 RGD:5490966 RGD:8663430 RGD:8663431 RGD:8693397
NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928
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Tp63
tumor protein p63
ISO
RGD
PMID:22713868 PMID:23263379
RGD:8663430 RGD:8663431
NCBI chrNW_004955420:18,178,639...18,384,786
Ensembl chrNW_004955420:18,176,155...18,384,786
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Tp73
tumor protein p73
ISO
RGD
PMID:22713868 PMID:23263379
RGD:8663430 RGD:8663431
NCBI chrNW_004955486:7,914,608...7,961,992
Ensembl chrNW_004955486:7,914,440...7,952,982
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Vdr
vitamin D receptor
ISO
RGD
PMID:22713868
RGD:8663430
NCBI chrNW_004955500:6,745,725...6,798,052
Ensembl chrNW_004955500:6,745,678...6,798,048
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Abca4
ATP binding cassette subfamily A member 4
ISO
RGD
PMID:20212494
RGD:8547536
NCBI chrNW_004955423:612,098...738,702
Ensembl chrNW_004955423:612,098...736,035
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Lrat
lecithin retinol acyltransferase
ISO
RGD
PMID:20212494
RGD:8547536
NCBI chrNW_004955471:2,603,395...2,610,988
Ensembl chrNW_004955471:2,603,678...2,609,079
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Rbp3
retinol binding protein 3
ISO
RGD
PMID:20212494
RGD:8547536
NCBI chrNW_004955556:2,217,528...2,225,369
Ensembl chrNW_004955556:2,217,440...2,225,501
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Rdh12
retinol dehydrogenase 12
ISO
RGD
PMID:20212494
RGD:8547536
NCBI chrNW_004955466:2,473,145...2,485,779
Ensembl chrNW_004955466:2,473,096...2,487,623
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Rlbp1
retinaldehyde binding protein 1
ISO
RGD
PMID:20212494
RGD:8547536
NCBI chrNW_004955416:15,862,510...15,873,261
Ensembl chrNW_004955416:15,862,426...15,873,327
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Rpe65
retinoid isomerohydrolase RPE65
ISO
RGD
PMID:20212494
RGD:8547536
NCBI chrNW_004955423:23,184,326...23,208,206
Ensembl chrNW_004955423:23,183,937...23,208,282
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Dnajc13
DnaJ heat shock protein family (Hsp40) member C13
ISO
RGD
PMID:25701813
RGD:10450845
NCBI chrNW_004955501:5,980,407...6,111,424
Ensembl chrNW_004955501:5,976,182...6,093,384
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Vps35
VPS35 retromer complex component
ISO
RGD
PMID:25619244 PMID:25701813
RGD:10450542 RGD:10450845
NCBI chrNW_004955448:207,582...240,264
Ensembl chrNW_004955448:204,991...240,160
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Abca1
ATP binding cassette subfamily A member 1
ISO
RGD
PMID:11086027
RGD:1600951
NCBI chrNW_004955419:21,553,863...21,681,626
Ensembl chrNW_004955419:21,553,835...21,681,619
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Abca3
ATP binding cassette subfamily A member 3
ISO
RGD
PMID:15985750
RGD:1549859
NCBI chrNW_004955442:14,933,550...14,989,492
Ensembl chrNW_004955442:14,933,550...14,989,492
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Actl6a
actin like 6A
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chrNW_004955420:8,745,390...8,764,993
Ensembl chrNW_004955420:8,744,597...8,764,993
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Arid1a
AT-rich interaction domain 1A
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chrNW_004955452:6,068,631...6,120,759
Ensembl chrNW_004955452:6,068,631...6,120,759
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Arid1b
AT-rich interaction domain 1B
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chrNW_004955439:5,041,111...5,454,692
Ensembl chrNW_004955439:5,043,967...5,412,741
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Pbrm1
polybromo 1
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chrNW_004955430:2,536,086...2,671,094
Ensembl chrNW_004955430:2,536,086...2,670,617
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Smarca4
SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4
ISO
RGD
PMID:23355908
RGD:8694154
NCBI chrNW_004955495:2,021,671...2,105,155
Ensembl chrNW_004955495:2,021,566...2,105,397
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Ube2d3
ubiquitin conjugating enzyme E2 D3
ISO
RGD
PMID:11020223
RGD:1302873
NCBI chrNW_004955496:5,694,471...5,727,003
Ensembl chrNW_004955496:5,697,276...5,727,003
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Ube2d4
ubiquitin conjugating enzyme E2 D4 (putative)
ISO
RGD
PMID:11020223
RGD:1302873
NCBI chrNW_004955456:7,928,715...7,952,155
Ensembl chrNW_004955456:7,924,977...7,952,155
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Ube2g1
ubiquitin conjugating enzyme E2 G1
ISO
RGD
PMID:11020223
RGD:1302873
NCBI chrNW_004955467:12,552,001...12,639,620
Ensembl chrNW_004955467:12,551,826...12,640,786
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Ube2i
ubiquitin conjugating enzyme E2 I
ISO
RGD
PMID:11020223
RGD:1302873
NCBI chrNW_004955442:15,902,026...15,913,033
Ensembl chrNW_004955442:15,901,980...15,913,037
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Ube2n
ubiquitin conjugating enzyme E2 N
ISO
RGD
PMID:11020223
RGD:1302873
NCBI chrNW_004955405:30,240,402...30,278,362
Ensembl chrNW_004955405:30,240,408...30,278,360
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Flt4
fms related receptor tyrosine kinase 4
ISO
RGD
PMID:15563310
RGD:1334463
NCBI chrNW_004955408:98,995...137,922
Ensembl chrNW_004955408:107,056...140,056
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Kdr
kinase insert domain receptor
ISO
RGD
PMID:18221855
RGD:2292019
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
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Vegfa
vascular endothelial growth factor A
ISO
RGD
PMID:18221855
RGD:2292019
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
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Flt4
fms related receptor tyrosine kinase 4
ISO
RGD
PMID:15563310
RGD:1334463
NCBI chrNW_004955408:98,995...137,922
Ensembl chrNW_004955408:107,056...140,056
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Kdr
kinase insert domain receptor
ISO
RGD
PMID:18221855
RGD:2292019
NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583
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Vegfa
vascular endothelial growth factor A
ISO
RGD
PMID:18221855
RGD:2292019
NCBI chrNW_004955437:9,527,445...9,541,908
Ensembl chrNW_004955437:9,531,362...9,542,664
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all