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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:type 2 diabetes mellitus pathway
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Accession:PW:0000208 term browser browse the term
Definition:Diabetes mellitus is characterized by abnormally high levels of glucose in the blood. Hereditary and environmental factors are likely contributors but the exact mechanisms are not well understood. Type 2 diabetes mellitus, characterized by insulin resistance, involves alterations in insulin secretion and signaling and impaired glucose homeostasis pathways.
Synonyms:exact_synonym: NIDDM pathway;   T2D pathway;   non-insulin-dependent diabetes mellitus pathway
 related_synonym: KEGG:04930;   type II diabetes mellitus pathway
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type 2 diabetes mellitus pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 ISO
IEA 		DNA:missense mutation::A1369S (human) KEGG
RGD		 PMID:17259403 rno:04930, RGD:2313628 NCBI chr 1:105,734,992...105,816,272
Ensembl chr 1:105,734,992...105,815,982 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing IEA KEGG rno:04930 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:91,226,180...91,240,169 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO RGD PMID:15166380 RGD:2313408 NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A IEA KEGG rno:04930 NCBI chr19:40,425,560...40,724,810
Ensembl chr19:40,425,560...40,724,599 		JBrowse link
G Cacna1b calcium voltage-gated channel subunit alpha1 B IEA KEGG rno:04930 NCBI chr 3:27,779,133...27,944,292
Ensembl chr 3:27,779,166...27,944,285 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C IEA KEGG rno:04930 NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:153,436,427...154,051,762 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D IEA KEGG rno:04930 NCBI chr16:5,233,682...5,527,549
Ensembl chr16:5,233,690...5,674,692 		JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E IEA KEGG rno:04930 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G IEA KEGG rno:04930 NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,851,896...79,919,634 		JBrowse link
G Gck glucokinase IEA KEGG rno:04930 NCBI chr14:84,999,019...85,041,098
Ensembl chr14:84,999,020...85,040,949 		JBrowse link
G Hk1 hexokinase 1 IEA KEGG rno:04930 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814 		JBrowse link
G Hk2 hexokinase 2 IEA KEGG rno:04930 NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:116,792,258...116,841,275 		JBrowse link
G Hk3 hexokinase 3 IEA KEGG rno:04930 NCBI chr17:9,602,119...9,620,038
Ensembl chr17:9,605,016...9,620,037 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:04930 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911 		JBrowse link
G Ins1 insulin 1 IEA KEGG rno:04930 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682 		JBrowse link
G Ins2 insulin 2 ISO
IEA 		KEGG
RGD		 PMID:9809695 rno:04930, RGD:2313694 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805 		JBrowse link
G Insr insulin receptor ISO
IEA 		KEGG
RGD		 PMID:9809695 rno:04930, RGD:2313694 NCBI chr12:5,991,135...6,129,275
Ensembl chr12:5,981,835...6,128,803 		JBrowse link
G Irs1 insulin receptor substrate 1 IEA KEGG rno:04930 NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:90,993,519...91,054,538 		JBrowse link
G Irs2 insulin receptor substrate 2 IEA KEGG rno:04930 NCBI chr16:85,190,310...85,214,543
Ensembl chr16:85,190,111...85,214,543 		JBrowse link
G Irs3 insulin receptor substrate 3 IEA KEGG rno:04930 NCBI chr12:24,689,930...24,692,068
Ensembl chr12:24,689,909...24,692,068 		JBrowse link
G Irs4 insulin receptor substrate 4 IEA KEGG rno:04930 NCBI chr  X:110,132,490...110,148,473
Ensembl chr  X:110,132,405...110,149,088 		JBrowse link
G Kcnj11 potassium inwardly-rectifying channel, subfamily J, member 11 ISO
IEA 		polymorphisms in the human gene are linked to altered insulin secretion; E23K polymorphism appears to confer susceptibility to diabetes type-2 in Caucasian population
DNA:missense mutation::p.E23K (human) 		KEGG
RGD		 PMID:15565284 PMID:17259403 rno:04930, RGD:2313610, RGD:2313628 NCBI chr 1:105,727,473...105,731,167
Ensembl chr 1:105,727,570...105,731,169 		JBrowse link
G Mafa MAF bZIP transcription factor A IEA KEGG rno:04930 NCBI chr 7:109,313,021...109,315,813
Ensembl chr 7:109,313,121...109,315,760 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA KEGG rno:04930 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04930 NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,802,295...7,094,100 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:04930 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04930 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04930 NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEA KEGG rno:04930 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 IEA KEGG rno:04930 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha IEA KEGG rno:04930 NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04930 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:108,474,019...108,579,331 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04930 NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:165,377,994...165,403,968 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IEA KEGG rno:04930 NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:34,612,946...34,626,347 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04930 NCBI chr16:18,699,389...18,708,045
Ensembl chr16:18,699,448...18,709,665 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04930 NCBI chr 5:134,936,790...135,009,303
Ensembl chr 5:134,934,857...135,007,762 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04930 NCBI chr10:53,631,469...53,699,550
Ensembl chr10:53,631,476...53,699,539 		JBrowse link
G Pklr pyruvate kinase L/R IEA KEGG rno:04930 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644 		JBrowse link
G Prkcd protein kinase C, delta IEA KEGG rno:04930 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839 		JBrowse link
G Prkce protein kinase C, epsilon IEA KEGG rno:04930 NCBI chr 6:13,718,050...14,204,931
Ensembl chr 6:13,718,050...14,204,288 		JBrowse link
G Prkcz protein kinase C, zeta IEA KEGG rno:04930 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:171,101,774...171,212,674 		JBrowse link
G Slc2a2 solute carrier family 2 member 2 IEA KEGG rno:04930 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 IEA KEGG rno:04930 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 IEA KEGG rno:04930 NCBI chr10:5,389,574...5,391,265
Ensembl chr10:5,389,334...5,391,847 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 IEA KEGG rno:04930 NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:31,874,463...31,930,423 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 IEA KEGG rno:04930 NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,690,976...103,704,825 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 IEA KEGG rno:04930 NCBI chr15:23,003,130...23,017,615
Ensembl chr15:23,002,883...23,022,499 		JBrowse link
G Tnf tumor necrosis factor IEA KEGG rno:04930 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      cardiovascular system disease pathway 254
        metabolic syndrome X pathway 49
          type 2 diabetes mellitus pathway 48
Path 2
Term Annotations click to browse term
  pathway 6091
    disease pathway 1954
      nutritional and metabolic disease pathway 709
        metabolic disease pathway 666
          glucose metabolism disease pathway 148
            diabetes mellitus pathway 134
              type 2 diabetes mellitus pathway 48
paths to the root