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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).

Term:G protein mediated signaling pathway
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Accession:PW:0000125 term browser browse the term
Definition:G-proteins act as signal transducers between activated receptors or other incoming signals and downstream effectors. They comprise the heterotrimeric G proteins downstream of G protein coupled receptors (GPCRs) and the Ras superfamily of small, monomeric G proteins. They function as molecular switches alternating between the GDP-inactive and GTP-active bound state.
Synonyms:related_synonym: heterotrimeric G protein mediated signaling pathway


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G protein mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A IDA RGD PMID:11257446 RGD:6907050 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568
JBrowse link
G F2r coagulation factor II (thrombin) receptor IMP RGD PMID:15145074 RGD:1582290 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Gnao1 G protein subunit alpha o1 IMP RGD PMID:18162464 RGD:2301999 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 IEP RGD PMID:29081032 RGD:13506833 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP RGD PMID:29081032 RGD:13506833 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Ltb4r leukotriene B4 receptor ISO RGD PMID:16043658 RGD:1581956 NCBI chr15:34,449,299...34,453,352
Ensembl chr15:34,452,116...34,453,171
JBrowse link
G Plcd1 phospholipase C, delta 1 IDA RGD PMID:8663582 RGD:2301018 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
Arf family mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap2a1 adaptor related protein complex 2 subunit alpha 1 ISO PID PID:200195 NCBI chr 1:100,896,582...100,926,443
Ensembl chr 1:100,896,947...100,926,335
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 ISO PID PID:200195 NCBI chr11:84,041,184...84,047,542
Ensembl chr11:84,041,184...84,047,546
JBrowse link
G Arf1 ADP-ribosylation factor 1 ISO PID PID:200195 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arfgap1 ADP-ribosylation factor GTPase activating protein 1 ISO PID PID:200195 NCBI chr 3:176,475,847...176,490,642
Ensembl chr 3:176,475,893...176,489,925
JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 ISO PID PID:200195 NCBI chr 1:170,464,995...170,471,138
Ensembl chr 1:170,466,395...170,471,076
JBrowse link
G Arl6 ADP-ribosylation factor like GTPase 6 ISO RGD PMID:15314642 RGD:1578724 NCBI chr11:42,858,476...42,884,324
Ensembl chr11:42,858,478...42,884,603
JBrowse link
G Asap1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO PID PID:200195 NCBI chr 7:104,670,076...104,951,090
Ensembl chr 7:104,669,672...104,801,045
JBrowse link
G Cd4 Cd4 molecule ISO PID PID:200195 NCBI chr 4:157,381,862...157,408,357
Ensembl chr 4:157,383,052...157,408,176
JBrowse link
G Clta clathrin, light chain A ISO PID PID:200195 NCBI chr 5:59,490,689...59,509,139
Ensembl chr 5:59,491,096...59,509,138
JBrowse link
G Cltb clathrin, light chain B ISO PID PID:200195 NCBI chr17:10,537,348...10,554,999
Ensembl chr17:10,537,365...10,554,989
JBrowse link
G Copa COPI coat complex subunit alpha ISO PID PID:200195 NCBI chr13:90,467,285...90,508,894
Ensembl chr13:90,467,265...90,508,932
JBrowse link
G Cyth2 cytohesin 2 ISO PID PID:200195 NCBI chr 1:101,796,349...101,803,407
Ensembl chr 1:101,796,349...101,803,200
JBrowse link
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 ISO PID PID:200195 NCBI chr 1:265,904,616...266,033,107
Ensembl chr 1:265,904,566...266,033,156
JBrowse link
G Gga3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 ISO PID PID:200195 NCBI chr10:104,137,655...104,156,576
Ensembl chr10:104,137,655...104,156,576
JBrowse link
G Git1 GIT ArfGAP 1 IDA RGD PMID:9826657 RGD:68782 NCBI chr10:62,656,000...62,664,467
Ensembl chr10:62,656,000...62,664,466
JBrowse link
G Gosr2 golgi SNAP receptor complex member 2 ISO PID PID:200195 NCBI chr10:91,735,772...91,756,123
Ensembl chr10:91,736,780...91,756,081
JBrowse link
G Kdelr1 KDEL endoplasmic reticulum protein retention receptor 1 ISO PID PID:200195 NCBI chr 1:101,859,346...101,870,232
Ensembl chr 1:101,859,346...101,870,232
JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha ISO PID PID:200195 NCBI chr 2:196,227,669...196,270,949
Ensembl chr 2:196,227,670...196,270,826
JBrowse link
G Pld2 phospholipase D2 ISO PID PID:200195 NCBI chr10:57,161,921...57,181,148
Ensembl chr10:57,163,174...57,179,730
JBrowse link
G Rac1 Rac family small GTPase 1 ISO PID PID:200195 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Uso1 USO1 vesicle transport factor ISO PID PID:200195 NCBI chr14:17,371,451...17,436,948
Ensembl chr14:17,371,453...17,436,897
JBrowse link
G protein mediated signaling pathway via Galpha12/Galpha13 family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:9092554 RGD:1582440 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Casr calcium-sensing receptor ISO RGD PMID:22192592 RGD:7207059 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Gna13 G protein subunit alpha 13 IMP RGD PMID:9092554 RGD:1582440 NCBI chr10:97,647,196...97,680,030
Ensembl chr10:97,647,111...97,684,730
JBrowse link
G Gnb1 G protein subunit beta 1 IMP RGD PMID:9092554 RGD:1582440 NCBI chr 5:172,914,025...172,981,403
Ensembl chr 5:172,934,990...172,979,986
JBrowse link
G Gng3 G protein subunit gamma 3 IMP RGD PMID:9092554 RGD:1582440 NCBI chr 1:225,033,921...225,035,687
Ensembl chr 1:225,033,921...225,035,687
JBrowse link
G Rgs12 regulator of G-protein signaling 12 ISO RGD PMID:12239094 RGD:7207227 NCBI chr14:80,975,239...81,069,519
Ensembl chr14:80,975,322...81,053,906
JBrowse link
G protein mediated signaling pathway via Galphai family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy5 adenylate cyclase 5 ISO RGD PMID:26468202 RGD:11041137 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adrb2 adrenoceptor beta 2 IMP RGD PMID:10577992 RGD:1559319 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Agtr2 angiotensin II receptor, type 2 TAS
ISO
RGD PMID:14657020, PMID:22949090 RGD:1566502, RGD:7401256 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Casr calcium-sensing receptor IMP RGD PMID:22192592 RGD:7207059 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:12121979, PMID:21303898 RGD:1581445, RGD:11041134 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd3 dopamine receptor D3 ISO RGD PMID:21303898 RGD:11041134 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Drd4 dopamine receptor D4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483
JBrowse link
G Gnai1 G protein subunit alpha i1 IMP
ISO
RGD PMID:12890892, PMID:23759942 RGD:1642020, RGD:8549590 NCBI chr 4:13,405,136...13,486,866
Ensembl chr 4:13,405,136...13,485,883
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:22949090, PMID:24831693, PMID:23759942 RGD:7401256, RGD:11041136, RGD:8549590 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Gnai3 G protein subunit alpha i3 ISO RGD PMID:22949090 RGD:7401256 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749
JBrowse link
G Gnao1 G protein subunit alpha o1 ISO RGD PMID:24831693 RGD:11041136 NCBI chr19:11,513,201...11,669,578
Ensembl chr19:11,513,201...11,669,578
JBrowse link
G Hcrtr2 hypocretin receptor 2 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 8:83,307,684...83,421,612
Ensembl chr 8:83,307,684...83,421,612
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IMP RGD PMID:16242672 RGD:1626474 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 IMP RGD PMID:16242672 RGD:1626474 NCBI chr 2:252,090,634...252,159,221
Ensembl chr 2:252,090,669...252,159,903
JBrowse link
G Oxtr oxytocin receptor ISO
IMP
RGD PMID:12826328, PMID:9575824 RGD:1579893, RGD:2304227 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:12239094, PMID:21303898 RGD:7207227, RGD:11041134 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rgs5 regulator of G-protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr13:87,966,820...88,002,831
Ensembl chr13:87,966,758...88,003,035
JBrowse link
G Rgs7 regulator of G-protein signaling 7 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:93,095,659...93,534,452
Ensembl chr13:93,095,200...93,307,199
JBrowse link
G Rgs7bp regulator of G-protein signaling 7 binding protein ISO RGD PMID:21303898 RGD:11041134 NCBI chr 2:35,072,081...35,619,085
Ensembl chr 2:35,077,504...35,104,963
JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO RGD PMID:21303898 RGD:11041134 NCBI chr10:97,509,971...97,582,188
Ensembl chr10:97,509,971...97,582,188
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 IMP RGD PMID:11557736 RGD:1581747 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G protein mediated signaling pathway via Galphaq family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A ISS RGD PMID:11454900 RGD:1559318 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B ISS RGD PMID:11454900 RGD:1559318 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D ISS RGD PMID:11454900 RGD:1559318 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Agtr1a angiotensin II receptor, type 1a IMP RGD PMID:11906170, PMID:12446719 RGD:70819, RGD:629553 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:14624682 RGD:1579891 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO
IDA
RGD PMID:14624682, PMID:19047484 RGD:1579891, RGD:2312649 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
JBrowse link
G Bdkrb1 bradykinin receptor B1 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bdkrb2 bradykinin receptor B2 ISO RGD PMID:16177542 RGD:7401223 NCBI chr 6:129,399,468...129,429,676
Ensembl chr 6:129,399,468...129,429,676
JBrowse link
G Casr calcium-sensing receptor IMP RGD PMID:22192592, PMID:12239094 RGD:7207059, RGD:7207227 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 ISO RGD PMID:23841840 RGD:8549585 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Drd1 dopamine receptor D1 ISO D1-D2 heterodimer RGD PMID:25671228 RGD:11041142 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 ISO D1-D2 heterodimer RGD PMID:25671228 RGD:11041142 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:25671228 RGD:11041142 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Ghsr growth hormone secretagogue receptor TAS RGD PMID:15788704 RGD:1642818 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:14624682, PMID:23759942, PMID:11395409 RGD:1579891, RGD:8549590, RGD:5131495 NCBI chr 7:11,033,400...11,047,284
Ensembl chr 7:11,033,317...11,047,437
JBrowse link
G Gna14 G protein subunit alpha 14 ISO RGD PMID:11395409, PMID:23759942 RGD:5131495, RGD:8549590 NCBI chr 1:235,165,775...235,347,986
Ensembl chr 1:235,166,718...235,347,937
JBrowse link
G Gna15 G protein subunit alpha 15 IMP
ISO
RGD PMID:9685675, PMID:11395409 RGD:728647, RGD:5131495 NCBI chr 7:11,054,249...11,075,152
Ensembl chr 7:11,054,333...11,077,251
JBrowse link
G Gnaq G protein subunit alpha q IMP
ISO
RGD PMID:12890892, PMID:23759942, PMID:11395409, PMID:14624682 RGD:1642020, RGD:8549590, RGD:5131495, RGD:1579891 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Hcrtr1 hypocretin receptor 1 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 5:148,346,029...148,355,404
Ensembl chr 5:148,346,031...148,355,406
JBrowse link
G Hcrtr2 hypocretin receptor 2 IDA RGD PMID:12890892 RGD:1642020 NCBI chr 8:83,307,684...83,421,612
Ensembl chr 8:83,307,684...83,421,612
JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 IMP RGD PMID:16504475 RGD:1626471 NCBI chr 5:75,557,038...75,678,067
Ensembl chr 5:75,557,042...75,676,584
JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 IMP RGD PMID:16504475 RGD:1626471 NCBI chr 2:252,090,634...252,159,221
Ensembl chr 2:252,090,669...252,159,903
JBrowse link
G Oxtr oxytocin receptor ISO
IMP
RGD PMID:14624682, PMID:9575824 RGD:1579891, RGD:2304227 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G Plcb1 phospholipase C beta 1 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb2 phospholipase C, beta 2 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:110,497,760...110,517,563
Ensembl chr 3:110,498,114...110,517,163
JBrowse link
G Plcb3 phospholipase C beta 3 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcb4 phospholipase C, beta 4 ISO RGD PMID:11395409 RGD:5131495 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Pth1r parathyroid hormone 1 receptor IDA
ISO
RGD PMID:9054374, PMID:19395963, PMID:21777186 RGD:7207455, RGD:7207470, RGD:7207465 NCBI chr 8:118,984,531...119,012,803
Ensembl chr 8:118,988,053...119,012,671
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:12588881, PMID:12239094 RGD:5133418, RGD:7207227 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:12239094 RGD:7207227 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rgs5 regulator of G-protein signaling 5 ISO RGD PMID:21393447 RGD:7207228 NCBI chr13:87,966,820...88,002,831
Ensembl chr13:87,966,758...88,003,035
JBrowse link
G protein mediated signaling pathway via Galphas family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 ISO RGD PMID:18948702 RGD:2312469 NCBI chr14:87,311,970...87,429,880
Ensembl chr14:87,312,203...87,421,659
JBrowse link
G Adcy2 adenylate cyclase 2 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 1:37,043,071...37,698,390
Ensembl chr 1:37,507,276...37,698,390
JBrowse link
G Adcy3 adenylate cyclase 3 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 6:28,570,941...28,648,848
Ensembl chr 6:28,571,351...28,650,148
JBrowse link
G Adcy4 adenylate cyclase 4 ISO RGD PMID:18948702 RGD:2312469 NCBI chr15:34,453,917...34,469,779
Ensembl chr15:34,453,915...34,469,746
JBrowse link
G Adcy5 adenylate cyclase 5 ISO
IDA
RGD PMID:18948702, PMID:26468202, PMID:17010343 RGD:2312469, RGD:11041137, RGD:2315004 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy6 adenylate cyclase 6 ISO
IDA
RGD PMID:18948702, PMID:17010343, PMID:15579502 RGD:2312469, RGD:2315004, RGD:2313211 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcy7 adenylate cyclase 7 ISO RGD PMID:18948702 RGD:2312469 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Adcy8 adenylate cyclase 8 ISO RGD PMID:18948702 RGD:2312469 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Adcy9 adenylate cyclase 9 ISO RGD PMID:18948702 RGD:2312469 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
G Adrb1 adrenoceptor beta 1 TAS RGD PMID:10577992 RGD:1559319 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 TAS RGD PMID:10577992 RGD:1559319 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 ISO RGD PMID:8011597 RGD:1559323 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Avpr1b arginine vasopressin receptor 1B IDA RGD PMID:19047484 RGD:2312649 NCBI chr13:48,367,307...48,378,831
Ensembl chr13:48,367,307...48,378,831
JBrowse link
G Avpr2 arginine vasopressin receptor 2 ISO RGD PMID:14624682 RGD:1579891 NCBI chr  X:156,889,006...156,892,707
Ensembl chr  X:156,889,410...156,891,213
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 ISO RGD PMID:16484629 RGD:5147387 NCBI chr10:92,191,473...92,233,662
Ensembl chr10:92,191,718...92,232,645
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 ISO RGD PMID:16484629 RGD:5147387 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Drd1 dopamine receptor D1 ISO RGD PMID:21303898 RGD:11041134 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd5 dopamine receptor D5 ISO RGD PMID:21303898 RGD:11041134 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Gcgr glucagon receptor IDA RGD PMID:17010343 RGD:2315004 NCBI chr10:109,707,863...109,716,253
Ensembl chr10:109,707,962...109,716,128
JBrowse link
G Gnal G protein subunit alpha L ISO RGD PMID:24144882 RGD:11041135 NCBI chr18:62,805,406...62,946,133
Ensembl chr18:62,805,410...62,944,630
JBrowse link
G Gnas GNAS complex locus IDA
IMP
ISO
RGD PMID:15297467, PMID:17010343, PMID:15687107, PMID:15579502, PMID:14624682, PMID:18948702 RGD:1580407, RGD:2315004, RGD:1625210, RGD:2313211, RGD:1579891, RGD:2312469 NCBI chr 3:172,374,957...172,434,988
Ensembl chr 3:172,374,957...172,428,483
Ensembl chr 3:172,374,957...172,428,483
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 ISO RGD PMID:19767412 RGD:5128698 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Grk2 G protein-coupled receptor kinase 2 TAS RGD PMID:1403099 RGD:632163 NCBI chr 1:219,536,220...219,544,329
Ensembl chr 1:219,536,220...219,544,328
JBrowse link
G Grk3 G protein-coupled receptor kinase 3 TAS RGD PMID:1403099 RGD:632163 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor IDA RGD PMID:8440169 RGD:2292602 NCBI chr 6:12,493,182...12,554,482
Ensembl chr 6:12,493,943...12,554,439
JBrowse link
G Mc1r melanocortin 1 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mc2r melanocortin 2 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
JBrowse link
G Mc3r melanocortin 3 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr 3:170,252,901...170,253,998
Ensembl chr 3:170,252,901...170,253,998
JBrowse link
G Mc4r melanocortin 4 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:62,612,838...62,614,725
Ensembl chr18:62,612,838...62,614,725
JBrowse link
G Mc5r melanocortin 5 receptor ISO RGD PMID:20852827 RGD:5144213 NCBI chr18:64,113,659...64,118,700
Ensembl chr18:64,114,933...64,116,524
JBrowse link
G Pth1r parathyroid hormone 1 receptor ISO RGD PMID:21777186, PMID:19395963 RGD:7207465, RGD:7207470 NCBI chr 8:118,984,531...119,012,803
Ensembl chr 8:118,988,053...119,012,671
JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rgs7 regulator of G-protein signaling 7 ISO RGD PMID:21303898 RGD:11041134 NCBI chr13:93,095,659...93,534,452
Ensembl chr13:93,095,200...93,307,199
JBrowse link
G Rgs7bp regulator of G-protein signaling 7 binding protein ISO RGD PMID:21303898 RGD:11041134 NCBI chr 2:35,072,081...35,619,085
Ensembl chr 2:35,077,504...35,104,963
JBrowse link
G Rgs9 regulator of G-protein signaling 9 ISO RGD PMID:21303898 RGD:11041134 NCBI chr10:97,509,971...97,582,188
Ensembl chr10:97,509,971...97,582,188
JBrowse link
G Snx13 sorting nexin 13 ISO RGD PMID:17173929 RGD:4140388 NCBI chr 6:54,487,626...54,591,716
Ensembl chr 6:54,488,038...54,588,778
JBrowse link
Rab family mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actr2 actin related protein 2 IMP RGD PMID:20739464 RGD:10054052 NCBI chr14:104,338,486...104,375,840
Ensembl chr14:104,340,434...104,375,649
JBrowse link
G Actr3 actin related protein 3 IMP RGD PMID:20739464 RGD:10054052 NCBI chr13:41,695,520...41,738,622
Ensembl chr13:41,695,183...41,738,658
JBrowse link
G Arpc1a actin related protein 2/3 complex, subunit 1A ISO RGD PMID:20739464 RGD:10054052 NCBI chr12:11,272,609...11,294,084
Ensembl chr12:11,272,609...11,294,058
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B ISO RGD PMID:20739464 RGD:10054052 NCBI chr12:11,252,300...11,265,849
Ensembl chr12:11,252,296...11,265,865
JBrowse link
G Arpc2 actin related protein 2/3 complex, subunit 2 IMP RGD PMID:20739464 RGD:10054052 NCBI chr 9:81,518,163...81,548,871
Ensembl chr 9:81,518,176...81,548,871
JBrowse link
G Arpc3 actin related protein 2/3 complex, subunit 3 ISO RGD PMID:20739464 RGD:10054052 NCBI chr12:39,653,951...39,667,817
Ensembl chr12:39,653,953...39,667,849
JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 ISO RGD PMID:20739464 RGD:10054052 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984
JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 ISO RGD PMID:20739464 RGD:10054052 NCBI chr13:70,174,970...70,183,879
Ensembl chr13:70,174,936...70,183,879
JBrowse link
G Cfl1 cofilin 1 IMP RGD PMID:20739464 RGD:10054052 NCBI chr 1:220,869,805...220,873,337
Ensembl chr 1:220,869,805...220,873,337
JBrowse link
G Dennd1c DENN domain containing 1C ISO RGD PMID:24598362 RGD:10053653 NCBI chr 9:9,976,015...9,982,349
Ensembl chr 9:9,970,209...9,982,295
JBrowse link
G Dennd4a DENN domain containing 4A ISO RGD PMID:24598362 RGD:10053653 NCBI chr 8:70,293,355...70,406,675
Ensembl chr 8:70,317,586...70,406,751
JBrowse link
G Dennd4b DENN domain containing 4B ISO RGD PMID:24598362 RGD:10053653 NCBI chr 2:189,626,922...189,642,732
Ensembl chr 2:189,629,297...189,642,183
JBrowse link
G Dennd4c DENN domain containing 4C ISO RGD PMID:24598362 RGD:10053653 NCBI chr 5:105,100,081...105,195,634
Ensembl chr 5:105,114,433...105,193,988
JBrowse link
G Gdi2 GDP dissociation inhibitor 2 TAS RGD PMID:8188702 RGD:61604 NCBI chr17:70,299,177...70,325,864
Ensembl chr17:70,299,183...70,325,855
JBrowse link
G Limk1 LIM domain kinase 1 IMP RGD PMID:20739464 RGD:10054052 NCBI chr12:25,036,630...25,070,538
Ensembl chr12:25,036,605...25,070,539
JBrowse link
G Rab10 RAB10, member RAS oncogene family ISO RGD PMID:17629673, PMID:24598362, PMID:18171431, PMID:18570632 RGD:2302395, RGD:10053653, RGD:2306494, RGD:2302397 NCBI chr 6:27,668,387...27,721,120
Ensembl chr 6:27,668,403...27,721,120
JBrowse link
G Rab11a RAB11a, member RAS oncogene family ISO RGD PMID:17629673, PMID:18171431, PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr 8:70,192,975...70,215,719
Ensembl chr 8:70,192,975...70,215,719
JBrowse link
G Rab13 RAB13, member RAS oncogene family TAS RGD PMID:24598362 RGD:10053653 NCBI chr 2:189,581,209...189,586,358
Ensembl chr 2:189,581,644...189,586,338
JBrowse link
G Rab14 RAB14, member RAS oncogene family ISO RGD PMID:17629673, PMID:18171431, PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr 3:14,373,270...14,395,357
Ensembl chr 3:14,373,275...14,395,362
JBrowse link
G Rab2a RAB2A, member RAS oncogene family ISO RGD PMID:17629673, PMID:18171431, PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr 5:21,632,654...21,696,721
Ensembl chr 5:21,632,926...21,695,519
JBrowse link
G Rab3ip RAB3A interacting protein ISO RGD PMID:24598362 RGD:10053653 NCBI chr 7:59,927,486...59,971,518
Ensembl chr 7:59,928,426...59,957,232
JBrowse link
G Rab4a RAB4A, member RAS oncogene family ISO RGD PMID:17629673, PMID:18171431, PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr19:56,585,598...56,613,078
Ensembl chr19:56,585,767...56,613,075
JBrowse link
G Rab5a RAB5A, member RAS oncogene family ISO RGD PMID:17629673, PMID:18171431 RGD:2302395, RGD:2306494 NCBI chr 9:5,910...6,065 JBrowse link
G Rab8a RAB8A, member RAS oncogene family ISO RGD PMID:17629673, PMID:18171431, PMID:18570632 RGD:2302395, RGD:2306494, RGD:2302397 NCBI chr16:19,355,047...19,376,776
Ensembl chr16:19,355,048...19,376,776
JBrowse link
G Rab8b RAB8B, member RAS oncogene family ISO RGD PMID:18570632 RGD:2302397 NCBI chr 8:72,641,680...72,714,646
Ensembl chr 8:72,638,003...72,714,664
JBrowse link
G Ssh1 slingshot protein phosphatase 1 IMP RGD PMID:20739464 RGD:10054052 NCBI chr12:48,403,184...48,447,964
Ensembl chr12:48,403,797...48,446,977
JBrowse link
G Tbc1d1 TBC1 domain family member 1 TAS RGD PMID:24598362 RGD:10053653 NCBI chr14:45,598,753...45,797,650
Ensembl chr14:45,598,743...45,797,887
JBrowse link
G Tbc1d4 TBC1 domain family, member 4 ISO RGD PMID:17629673, PMID:18570632, PMID:18171431 RGD:2302395, RGD:2302397, RGD:2306494 NCBI chr15:85,927,978...86,105,829
Ensembl chr15:85,930,044...86,105,273
JBrowse link
Ras family mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IMP RGD PMID:15728722 RGD:1581104 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
Ras mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:9211935 RGD:1625352 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 IMP RGD PMID:9271418 RGD:1582133 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728
JBrowse link
G Hmga2 high mobility group AT-hook 2 IMP RGD PMID:11390395 RGD:1601592 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Tp73 tumor protein p73 IMP RGD PMID:17353261 RGD:2291838 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
Rheb mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rheb Ras homolog, mTORC1 binding TAS RGD PMID:15240005 RGD:1625609 NCBI chr 4:6,827,429...6,873,384
Ensembl chr 4:6,827,429...6,873,383
JBrowse link
Rho/Rac/Cdc42 mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:18306009 RGD:5129131 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Baiap2 BAR/IMD domain containing adaptor protein 2 ISO RGD PMID:24613967 RGD:10053654 NCBI chr10:109,107,326...109,187,458
Ensembl chr10:109,107,389...109,187,115
JBrowse link
G Cbl Cbl proto-oncogene ISO RGD PMID:24613967 RGD:10053654 NCBI chr 8:48,481,256...48,564,775
Ensembl chr 8:48,489,036...48,564,722
JBrowse link
G Cdc42 cell division cycle 42 IMP RGD PMID:9487126 RGD:2293350 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Crk CRK proto-oncogene, adaptor protein ISO RGD PMID:24613967 RGD:10053654 NCBI chr10:63,829,731...63,855,999
Ensembl chr10:63,829,807...63,852,780
JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:114,258,773...114,347,138
Ensembl chr 1:114,258,719...114,347,137
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein IDA RGD PMID:7835339 RGD:68218 NCBI chr16:58,776,489...59,247,752
Ensembl chr16:59,077,574...59,247,754
JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:16543720 RGD:4892323 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Flna filamin A ISO RGD PMID:12239094 RGD:7207227 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Iqgap1 IQ motif containing GTPase activating protein 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:142,525,041...142,615,673
Ensembl chr 1:142,525,046...142,615,673
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IMP RGD PMID:9487126 RGD:2293350 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Limk2 LIM domain kinase 2 ISS RGD PMID:10613909 RGD:1549432 NCBI chr14:83,564,048...83,641,996
Ensembl chr14:83,573,928...83,641,892
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IMP RGD PMID:9487126 RGD:2293350 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IMP RGD PMID:9487126 RGD:2293350 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Plekhg4 pleckstrin homology and RhoGEF domain containing G4 ISO RGD PMID:24613967 RGD:10053654 NCBI chr19:37,327,395...37,345,047
Ensembl chr19:37,330,930...37,345,040
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit IMP RGD PMID:16549782 RGD:8693756 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Prex1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 3:163,329,580...163,477,822
Ensembl chr 3:163,329,975...163,477,715
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:15158121 RGD:1642626 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Rac1 Rac family small GTPase 1 IMP
ISO
RGD PMID:9487126, PMID:24613967 RGD:2293350, RGD:10053654 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 3:8,189,594...8,307,077
Ensembl chr 3:8,192,575...8,304,976
JBrowse link
G Rhoa ras homolog family member A TAS
ISO
RGD PMID:12782387, PMID:12239094 RGD:1299238, RGD:7207227 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rhoq ras homolog family member Q ISO RGD PMID:24613967 RGD:10053654 NCBI chr 6:10,533,151...10,568,582
Ensembl chr 6:10,533,151...10,568,581
JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr 1:259,373,921...259,502,108
Ensembl chr 1:259,376,933...259,484,569
JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 ISO RGD PMID:24613967 RGD:10053654 NCBI chr11:29,931,083...30,061,173
Ensembl chr11:29,933,163...30,051,103
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6103
    signaling pathway 2646
      G protein mediated signaling pathway 160
        Ras superfamily mediated signaling pathway + 79
        altered G protein mediated signaling pathway + 0
        heterotrimeric G protein mediated signaling pathway + 78
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.