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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:intrinsic apoptotic pathway
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Accession:PW:0000104 term browser browse the term
Definition:The apoptotic pathway involving organelles, primarily the mitochondrion and endoplasmic reticulum (ER), and involving the pro- and anti-apoptotic members of the Bcl family of proteins, cytochrome C, formation of the apoptosome and activation of caspases.
Comment:The reference was compiled based on the information available in the cited article.
Synonyms:related_synonym: Intrinsic Pathway for Apoptosis;   intrinsic apoptotic signaling pathway
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intrinsic apoptotic pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apaf1 apoptotic peptidase activating factor 1 IEP RGD PMID:18931364 RGD:2313998 NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:27,381,855...27,466,772 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO
ISS 		RGD PMID:15632274 PMID:19641503 PMID:15632274 RGD:1579966, RGD:2314029, RGD:1579966 NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:213,562,187...213,572,034 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 IMP
ISO 		RGD PMID:18817839 PMID:17322918 RGD:2313963, RGD:2313975 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator ISO
IMP
IEP 		RGD PMID:15632274 PMID:18817839 PMID:17322918 PMID:18931364 PMID:18959742 RGD:1579966, RGD:2313963, RGD:2313975, RGD:2313998, RGD:2314140 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bax_v1 BCL2 associated X, apoptosis regulator, variant 1 ISS RGD PMID:15632274 RGD:1579966
G Bax_v2 BCL2 associated X, apoptosis regulator, variant 2 ISS RGD PMID:15632274 RGD:1579966
G Bbc3 Bcl-2 binding component 3 IDA
ISO 		RGD PMID:19095966 PMID:19641503 RGD:2313994, RGD:2314029 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666 		JBrowse link
G Bcl2 BCL2, apoptosis regulator ISO
IEP 		RGD PMID:15632274 PMID:17322918 PMID:18931364 PMID:18959742 RGD:1579966, RGD:2313975, RGD:2313998, RGD:2314140 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2a1 BCL2-related protein A1 ISO RGD PMID:17322918 RGD:2313975 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890 		JBrowse link
G Bcl2l1 Bcl2-like 1 ISO
IEP 		RGD PMID:15632274 PMID:17322918 PMID:18959742 RGD:1579966, RGD:2313975, RGD:2314140 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bcl2l10 Bcl2-like 10 ISO RGD PMID:17322918 RGD:2313975 NCBI chr 8:84,987,833...84,993,878
Ensembl chr 8:84,987,833...84,993,872 		JBrowse link
G Bcl2l11 Bcl2-like 11 ISO RGD PMID:19641503 RGD:2314029 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695 		JBrowse link
G Bcl2l2 Bcl2-like 2 IMP
ISO 		RGD PMID:18817839 PMID:17322918 RGD:2313963, RGD:2313975 NCBI chr15:32,326,686...32,337,834
Ensembl chr15:32,326,020...32,335,379 		JBrowse link
G Bid BH3 interacting domain death agonist IEP
ISO 		RGD PMID:18931364 PMID:18090083 PMID:19641503 RGD:2313998, RGD:2314002, RGD:2314029 NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:155,785,377...155,808,275 		JBrowse link
G Bik BCL2-interacting killer ISO RGD PMID:19641503 RGD:2314029 NCBI chr 7:116,552,303...116,571,317
Ensembl chr 7:116,552,303...116,571,317 		JBrowse link
G Bmf Bcl2 modifying factor ISO RGD PMID:19641503 RGD:2314029 NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:125,953,466...125,974,258 		JBrowse link
G Bnip1 BCL2 interacting protein 1 IEP
ISO 		RGD PMID:12714334 PMID:19641503 RGD:634759, RGD:2314029 NCBI chr10:16,891,317...16,903,561
Ensembl chr10:16,891,317...16,903,561 		JBrowse link
G Bnip3 BCL2 interacting protein 3 TAS
ISO 		RGD PMID:14972662 PMID:19641503 RGD:2314028, RGD:2314029 NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:203,137,778...203,154,962 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like ISO RGD PMID:19641503 RGD:2314029 NCBI chr15:45,350,081...45,373,213
Ensembl chr15:45,334,537...45,373,282 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK IDA
ISO 		RGD PMID:9356461 PMID:17322918 RGD:70678, RGD:2313975 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833 		JBrowse link
G Casp3 caspase 3 IMP
IEP
ISO 		RGD PMID:18817839 PMID:18931364 PMID:18090083 PMID:17082813 PMID:17869439 RGD:2313963, RGD:2313998, RGD:2314002, RGD:2314187, RGD:2314390 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp7 caspase 7 ISO RGD PMID:17082813 RGD:2314187 NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:265,442,676...265,482,512 		JBrowse link
G Casp9 caspase 9 IMP
IEP
ISO 		RGD PMID:18817839 PMID:18931364 PMID:18090083 PMID:17082813 PMID:17869439 RGD:2313963, RGD:2313998, RGD:2314002, RGD:2314187, RGD:2314390 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cycs cytochrome c, somatic IMP
IEP 		RGD PMID:18817839 PMID:18931364 RGD:2313963, RGD:2313998 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Fas Fas cell surface death receptor IEP germ cells RGD PMID:17195944 RGD:1626509 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104 		JBrowse link
G Hrk harakiri, BCL2 interacting protein IMP
ISO 		RGD PMID:10075695 PMID:17428807 PMID:19641503 RGD:70327, RGD:2290488, RGD:2314029 NCBI chr12:44,048,402...44,070,561
Ensembl chr12:44,048,402...44,070,561 		JBrowse link
G Htra2 HtrA serine peptidase 2 IMP RGD PMID:16978742 RGD:2314385 NCBI chr 4:117,114,631...117,117,793
Ensembl chr 4:117,114,633...117,117,793 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member IDA
ISO 		RGD PMID:9356461 PMID:17322918 RGD:70678, RGD:2313975 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 ISO
IEP 		RGD PMID:19641503 PMID:18959742 RGD:2314029, RGD:2314140 NCBI chr18:62,255,970...62,262,384
Ensembl chr18:62,255,598...62,262,382 		JBrowse link
G Xiap X-linked inhibitor of apoptosis IMP RGD PMID:17869439 RGD:2314390 NCBI chr  X:125,756,107...125,803,979
Ensembl chr  X:125,737,971...125,803,978 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      cell death pathway 243
        programmed cell death pathway 243
          apoptotic cell death pathway 162
            intrinsic apoptotic pathway 30
              altered intrinsic apoptotic pathway 0
paths to the root