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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:citric acid cycle pathway
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Accession:PW:0000026 term browser browse the term
Definition:The series of chemical reactions that are central to all aerobic cells and constitute the citric acid cycle. Also known as the tricarboxylic acid cycle (TCA) or Krebs cycle, it is the center of convergence for all molecular fuels.
Synonyms:related_synonym: Citric acid cycle (TCA cycle);   Krebs cycle pathway;   TCA cycle pathway;   tricarboxylic acid cycle;   tricarboxylic acid cycle pathway
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citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase IEA KEGG mmu:00020 NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826 		JBrowse link
G Aco1 aconitase 1 IEA KEGG mmu:00020 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Aco2 aconitase 2, mitochondrial IEA
ISO 		KEGG
SMPDB
RGD		 PMID:9712727 SMP:00057 mmu:00020, RGD:2306877 NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334 		JBrowse link
G Cs citrate synthase ISO
IEA 		SMPDB
KEGG
RGD		 PMID:9712727 SMP:00057 mmu:00020, RGD:2306877 NCBI chr10:128,173,596...128,198,351
Ensembl chr10:128,173,603...128,198,348 		JBrowse link
G Csl citrate synthase like IEA KEGG mmu:00020 NCBI chr10:99,593,567...99,595,346
Ensembl chr10:99,593,568...99,595,520 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr 9:50,545,933...50,571,080
Ensembl chr 9:50,545,933...50,571,080 		JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO
IEA 		SMPDB
KEGG
RGD		 PMID:10672230 SMP:00057 mmu:00020, RGD:2306878 NCBI chr12:31,381,561...31,401,470
Ensembl chr12:31,381,276...31,401,452 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase ISO
IEA 		SMPDB
KEGG
RGD		 PMID:10672230 SMP:00057 mmu:00020, RGD:2306878 NCBI chr12:85,157,597...85,180,865
Ensembl chr12:85,157,607...85,181,619 		JBrowse link
G Fh1 fumarate hydratase 1 IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201 		JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble IEA KEGG mmu:00020 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial IEA KEGG mmu:00020 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr 9:54,493,795...54,511,946
Ensembl chr 9:54,493,618...54,511,945 		JBrowse link
G Idh3b isocitrate dehydrogenase 3 (NAD+) beta IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr 2:130,121,229...130,126,371
Ensembl chr 2:130,121,229...130,126,467 		JBrowse link
G Idh3g isocitrate dehydrogenase 3 (NAD+), gamma IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr  X:72,822,569...72,830,471
Ensembl chr  X:72,822,569...72,830,503 		JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) IEA KEGG mmu:00020 NCBI chr11:21,506,692...21,521,934
Ensembl chr11:21,506,692...21,522,367 		JBrowse link
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr 5:135,807,503...135,819,240
Ensembl chr 5:135,807,334...135,819,252 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 ISO SMPDB SMP:00057 NCBI chr17:8,502,590...8,516,499
Ensembl chr17:8,501,736...8,516,493 		JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) ISO
IEA 		SMPDB
KEGG
RGD		 PMID:9712727 PMID:10672230 SMP:00057 mmu:00020, RGD:2306877, RGD:2306878 NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642 		JBrowse link
G Ogdhl oxoglutarate dehydrogenase-like IEA KEGG mmu:00020 NCBI chr14:32,043,941...32,070,108
Ensembl chr14:32,043,976...32,070,108 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic IEA KEGG mmu:00020 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IEA KEGG mmu:00020 NCBI chr14:55,777,721...55,787,477
Ensembl chr14:55,777,723...55,788,699 		JBrowse link
G Pcx pyruvate carboxylase IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr19:4,560,500...4,671,780
Ensembl chr19:4,560,500...4,671,780 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 alpha 1 IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr  X:158,905,215...158,921,426
Ensembl chr  X:158,905,205...158,921,409 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 alpha 2 IEA KEGG mmu:00020 NCBI chr 3:140,915,765...140,918,116
Ensembl chr 3:140,915,765...140,918,116 		JBrowse link
G Pdhb pyruvate dehydrogenase (lipoamide) beta IEA
ISO 		KEGG
SMPDB		 SMP:00057 mmu:00020 NCBI chr14:14,296,470...14,303,782
Ensembl chr14:14,296,748...14,303,777 		JBrowse link
G Sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 mmu:00020, RGD:2306881 NCBI chr13:74,470,374...74,498,359
Ensembl chr13:74,470,373...74,498,399 		JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 mmu:00020, RGD:2306881 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504 		JBrowse link
G Sdhc succinate dehydrogenase complex, subunit C, integral membrane protein ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 mmu:00020, RGD:2306881 NCBI chr 1:170,956,726...170,978,209
Ensembl chr 1:170,954,734...170,978,172 		JBrowse link
G Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 mmu:00020, RGD:2306881 NCBI chr 9:50,507,640...50,515,149
Ensembl chr 9:50,507,657...50,515,112 		JBrowse link
G Sucla2 succinate-Coenzyme A ligase, ADP-forming, beta subunit ISO
IEA 		KEGG
RGD		 PMID:17403370 mmu:00020, RGD:2306915 NCBI chr14:73,790,226...73,833,584
Ensembl chr14:73,762,759...73,833,582 		JBrowse link
G Suclg1 succinate-CoA ligase, GDP-forming, alpha subunit ISO
IEA 		SMPDB
KEGG
RGD		 PMID:17403370 SMP:00057 mmu:00020, RGD:2306915 NCBI chr 6:73,225,488...73,253,890
Ensembl chr 6:73,225,365...73,253,894 		JBrowse link
G Suclg2 succinate-Coenzyme A ligase, GDP-forming, beta subunit ISO
IEA 		SMPDB
KEGG
RGD		 PMID:17403370 SMP:00057 mmu:00020, RGD:2306915 NCBI chr 6:95,449,992...95,695,799
Ensembl chr 6:95,449,990...95,695,781 		JBrowse link
altered citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fh1 fumarate hydratase 1 ISO RGD PMID:17211469 RGD:6907135 NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201 		JBrowse link
G Sdhb succinate dehydrogenase complex, subunit B, iron sulfur (Ip) ISO RGD PMID:21771581 RGD:6907134 NCBI chr 4:140,688,582...140,706,509
Ensembl chr 4:140,688,514...140,706,504 		JBrowse link
G Sdhd succinate dehydrogenase complex, subunit D, integral membrane protein ISO RGD PMID:21771581 RGD:6907134 NCBI chr 9:50,507,640...50,515,149
Ensembl chr 9:50,507,657...50,515,112 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6074
    classic metabolic pathway 1857
      energy metabolic pathway 179
        citric acid cycle pathway 32
          altered citric acid cycle pathway 3
Path 2
Term Annotations click to browse term
  pathway 6074
    regulatory pathway 3686
      homeostasis pathway 1721
        energy homeostasis pathway 457
          citric acid cycle pathway 32
            altered citric acid cycle pathway 3
paths to the root