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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:citric acid cycle pathway
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Accession:PW:0000026 term browser browse the term
Definition:The series of chemical reactions that are central to all aerobic cells and constitute the citric acid cycle. Also known as the tricarboxylic acid cycle (TCA) or Krebs cycle, it is the center of convergence for all molecular fuels.
Synonyms:related_synonym: Citric acid cycle (TCA cycle);   Krebs cycle pathway;   TCA cycle pathway;   tricarboxylic acid cycle;   tricarboxylic acid cycle pathway
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citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACLY ATP citrate lyase IEA KEGG hsa:00020 NCBI chr17:41,866,917...41,930,545
Ensembl chr17:41,866,917...41,930,542 		JBrowse link
G ACO1 aconitase 1 IEA KEGG hsa:00020 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769 		JBrowse link
G ACO2 aconitase 2 IEA
EXP
ISO 		KEGG
SMPDB
RGD		 PMID:9712727 SMP:00057 hsa:00020, RGD:2306877 NCBI chr22:41,469,117...41,528,974
Ensembl chr22:41,447,830...41,529,273 		JBrowse link
G CS citrate synthase ISO
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:9712727 SMP:00057 hsa:00020, RGD:2306877 NCBI chr12:56,271,699...56,300,330
Ensembl chr12:56,271,699...56,300,391 		JBrowse link
G DLAT dihydrolipoamide S-acetyltransferase IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr11:112,025,408...112,064,404
Ensembl chr11:112,025,033...112,064,404 		JBrowse link
G DLD dihydrolipoamide dehydrogenase TAS
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:10672230 SMP:00057 hsa:00020, RGD:2306878 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730 		JBrowse link
G DLST dihydrolipoamide S-succinyltransferase TAS
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:10672230 SMP:00057 hsa:00020, RGD:2306878 NCBI chr14:74,881,916...74,903,743
Ensembl chr14:74,881,891...74,903,743 		JBrowse link
G FH fumarate hydratase IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799 		JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 IEA KEGG hsa:00020 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074 		JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 IEA KEGG hsa:00020 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,477 		JBrowse link
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945 		JBrowse link
G IDH3B isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr20:2,658,395...2,664,216
Ensembl chr20:2,658,393...2,664,219 		JBrowse link
G IDH3G isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr  X:153,785,768...153,794,375
Ensembl chr  X:153,785,766...153,794,512 		JBrowse link
G MDH1 malate dehydrogenase 1 IEA KEGG hsa:00020 NCBI chr 2:63,588,963...63,607,197
Ensembl chr 2:63,588,609...63,607,197 		JBrowse link
G MDH2 malate dehydrogenase 2 IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr 7:76,048,106...76,067,508
Ensembl chr 7:76,048,051...76,067,508 		JBrowse link
G MPC1 mitochondrial pyruvate carrier 1 EXP SMPDB SMP:00057 NCBI chr 6:166,364,919...166,382,940
Ensembl chr 6:166,364,919...166,383,013 		JBrowse link
G OGDH oxoglutarate dehydrogenase ISO
EXP
IEA
TAS 		SMPDB
KEGG
RGD		 PMID:9712727 PMID:10672230 SMP:00057 hsa:00020, RGD:2306877, RGD:2306878 NCBI chr 7:44,606,627...44,709,066
Ensembl chr 7:44,606,572...44,709,066 		JBrowse link
G OGDHL oxoglutarate dehydrogenase L IEA KEGG hsa:00020 NCBI chr10:49,734,641...49,762,379
Ensembl chr10:49,734,641...49,762,379 		JBrowse link
G PC pyruvate carboxylase IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr11:66,848,420...66,958,383
Ensembl chr11:66,848,417...66,958,386 		JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 IEA KEGG hsa:00020 NCBI chr20:57,561,110...57,568,121
Ensembl chr20:57,561,080...57,568,121 		JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial IEA KEGG hsa:00020 NCBI chr14:24,094,171...24,104,125
Ensembl chr14:24,094,053...24,110,598 		JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr  X:19,343,927...19,361,718
Ensembl chr  X:19,343,893...19,361,718 		JBrowse link
G PDHA2 pyruvate dehydrogenase E1 subunit alpha 2 IEA KEGG hsa:00020 NCBI chr 4:95,840,093...95,841,464
Ensembl chr 4:95,840,093...95,841,464 		JBrowse link
G PDHB pyruvate dehydrogenase E1 subunit beta IEA
EXP 		KEGG
SMPDB		 SMP:00057 hsa:00020 NCBI chr 3:58,427,630...58,433,832
Ensembl chr 3:58,427,630...58,433,857 		JBrowse link
G SDHA succinate dehydrogenase complex flavoprotein subunit A TAS
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 hsa:00020, RGD:2306881 NCBI chr 5:218,320...268,746
Ensembl chr 5:218,303...257,082 		JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B TAS
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 hsa:00020, RGD:2306881 NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,664...17,054,151 		JBrowse link
G SDHC succinate dehydrogenase complex subunit C TAS
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 hsa:00020, RGD:2306881 NCBI chr 1:161,314,381...161,363,206
Ensembl chr 1:161,314,381...161,363,206 		JBrowse link
G SDHD succinate dehydrogenase complex subunit D TAS
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 hsa:00020, RGD:2306881 NCBI chr11:112,086,873...112,095,794
Ensembl chr11:112,086,824...112,120,016 		JBrowse link
G SUCLA2 succinate-CoA ligase ADP-forming subunit beta ISO
IEA 		KEGG
RGD		 PMID:17403370 hsa:00020, RGD:2306915 NCBI chr13:47,942,656...48,001,273
Ensembl chr13:47,745,736...48,037,968 		JBrowse link
G SUCLG1 succinate-CoA ligase GDP/ADP-forming subunit alpha ISO
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:17403370 SMP:00057 hsa:00020, RGD:2306915 NCBI chr 2:84,423,528...84,459,280
Ensembl chr 2:84,423,528...84,460,045 		JBrowse link
G SUCLG2 succinate-CoA ligase GDP-forming subunit beta ISO
EXP
IEA 		SMPDB
KEGG
RGD		 PMID:17403370 SMP:00057 hsa:00020, RGD:2306915 NCBI chr 3:67,360,460...67,654,612
Ensembl chr 3:67,360,460...67,654,612 		JBrowse link
altered citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FH fumarate hydratase TAS RGD PMID:17211469 RGD:6907135 NCBI chr 1:241,497,603...241,519,755
Ensembl chr 1:241,497,511...241,519,799 		JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B TAS RGD PMID:21771581 RGD:6907134 NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,664...17,054,151 		JBrowse link
G SDHD succinate dehydrogenase complex subunit D TAS RGD PMID:21771581 RGD:6907134 NCBI chr11:112,086,873...112,095,794
Ensembl chr11:112,086,824...112,120,016 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 5957
    classic metabolic pathway 1802
      energy metabolic pathway 157
        citric acid cycle pathway 31
          altered citric acid cycle pathway 3
Path 2
Term Annotations click to browse term
  pathway 5957
    regulatory pathway 3600
      homeostasis pathway 1667
        energy homeostasis pathway 436
          citric acid cycle pathway 31
            altered citric acid cycle pathway 3
paths to the root