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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (https://rgd.mcw.edu/rgdweb/contact/contactus.html).
Term:citric acid cycle pathway
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Accession:PW:0000026 term browser browse the term
Definition:The series of chemical reactions that are central to all aerobic cells and constitute the citric acid cycle. Also known as the tricarboxylic acid cycle (TCA) or Krebs cycle, it is the center of convergence for all molecular fuels.
Synonyms:related_synonym: Citric acid cycle (TCA cycle);   Krebs cycle pathway;   TCA cycle pathway;   tricarboxylic acid cycle;   tricarboxylic acid cycle pathway
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citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase IEA KEGG rno:00020 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320 		JBrowse link
G Aco1 aconitase 1 IEA KEGG rno:00020 NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Aco2 aconitase 2 IEA
ISO
IDA 		KEGG
SMPDB
RGD		 PMID:9712727 SMP:00057 rno:00020, RGD:2306877 NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:113,385,646...113,428,261 		JBrowse link
G Cs citrate synthase IEA
ISO
IDA 		KEGG
SMPDB
RGD		 PMID:9712727 SMP:00057 rno:00020, RGD:2306877 NCBI chr 7:1,348,389...1,374,624
Ensembl chr 7:758,345...791,421 		JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr 8:59,875,537...59,900,947
Ensembl chr 8:50,978,051...51,004,479
Ensembl chr 1:50,978,051...51,004,479 		JBrowse link
G Dld dihydrolipoamide dehydrogenase ISO
IEA 		SMPDB
KEGG
RGD		 PMID:10672230 SMP:00057 rno:00020, RGD:2306878 NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase ISO
IEA 		SMPDB
KEGG
RGD		 PMID:10672230 SMP:00057 rno:00020, RGD:2306878 NCBI chr 6:110,489,576...110,512,841
Ensembl chr 6:104,758,631...104,783,296 		JBrowse link
G Fh fumarate hydratase ISO SMPDB SMP:00057 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 IEA KEGG rno:00020 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 IEA KEGG rno:00020 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:134,029,772...134,058,025 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr 8:63,867,882...63,887,223
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr 3:137,934,971...137,940,275
Ensembl chr 3:117,481,845...117,486,982 		JBrowse link
G Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr  X:156,666,573...156,675,482
Ensembl chr  X:151,515,247...151,524,171 		JBrowse link
G Mdh1 malate dehydrogenase 1 IEA KEGG rno:00020 NCBI chr14:99,831,934...99,847,227
Ensembl chr14:95,630,306...95,645,925 		JBrowse link
G Mdh2 malate dehydrogenase 2 IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr12:26,530,886...26,543,841
Ensembl chr12:20,894,262...20,907,271 		JBrowse link
G Mpc1 mitochondrial pyruvate carrier 1 ISO SMPDB SMP:00057 NCBI chr 1:54,985,305...54,996,979
Ensembl chr 1:52,437,741...52,449,400 		JBrowse link
G Ogdh oxoglutarate dehydrogenase IDA
ISO
IEA 		SMPDB
KEGG
RGD		 PMID:9712727 PMID:10672230 SMP:00057 rno:00020, RGD:2306877, RGD:2306878 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Ogdhl oxoglutarate dehydrogenase L IEA KEGG rno:00020 NCBI chr16:7,584,666...7,610,705
Ensembl chr16:7,578,367...7,604,386 		JBrowse link
G Pc pyruvate carboxylase IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:201,804,267...201,898,380 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEA KEGG rno:00020 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IEA KEGG rno:00020 NCBI chr15:32,997,853...33,006,691
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr  X:38,509,158...38,522,986
Ensembl chr  X:34,700,409...34,714,311 		JBrowse link
G Pdha2 pyruvate dehydrogenase E1 subunit alpha 2 IEA KEGG rno:00020 NCBI chr 2:232,545,550...232,547,098 JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta IEA
ISO 		KEGG
SMPDB		 SMP:00057 rno:00020 NCBI chr15:19,182,789...19,188,731
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 rno:00020, RGD:2306881 NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 rno:00020, RGD:2306881 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 rno:00020, RGD:2306881 NCBI chr13:86,077,133...86,098,025
Ensembl chr13:83,544,652...83,566,253 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D ISO
IEA 		SMPDB
KEGG
RGD		 PMID:16143825 SMP:00057 rno:00020, RGD:2306881 NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
G Sucla2 succinate-CoA ligase ADP-forming subunit beta IDA
IEA 		KEGG
RGD		 PMID:17403370 rno:00020, RGD:2306915 NCBI chr15:55,161,894...55,215,031
Ensembl chr15:48,752,312...48,805,138 		JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha IDA
ISO
IEA 		SMPDB
KEGG
RGD		 PMID:17403370 SMP:00057 rno:00020, RGD:2306915 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600 		JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta IDA
ISO
IEA 		SMPDB
KEGG
RGD		 PMID:17403370 SMP:00057 rno:00020, RGD:2306915 NCBI chr 4:129,623,833...129,893,937
Ensembl chr 4:128,067,033...128,337,170 		JBrowse link
altered citric acid cycle pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fh fumarate hydratase ISO RGD PMID:17211469 RGD:6907135 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B ISO RGD PMID:21771581 RGD:6907134 NCBI chr 5:158,547,775...158,568,589
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D ISO RGD PMID:21771581 RGD:6907134 NCBI chr 8:59,841,090...59,850,641
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6091
    classic metabolic pathway 1852
      energy metabolic pathway 166
        citric acid cycle pathway 31
          altered citric acid cycle pathway 3
Path 2
Term Annotations click to browse term
  pathway 6091
    regulatory pathway 3866
      homeostasis pathway 1773
        energy homeostasis pathway 431
          citric acid cycle pathway 31
            altered citric acid cycle pathway 3
paths to the root