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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal manchette perinuclear ring morphology
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Accession:MP:0031373 term browser browse the term
Definition:any structural morphology of the ring-like portion of the manchette that surrounds the base of the elongating spermatid nucleus below the acroplaxome marginal ring and plays a key role in shaping the nucleus and the sperm head; microtubules extend from the perinuclear ring into the cytoplasm and/or basal body of the spermatid
Comment:Although the perinuclear ring is regarded as the microtubule-organizing center for the manchette, findings about the nucleation site and the direction of microtubules are inconsistent. During spermatid differentiation, the manchette moves toward the tail neck region, with constriction of the perinuclear ring, which contributes to sculpting of the sperm head in mice. {xref="PMID:33144677"}


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Term Annotations click to browse term
  mammalian phenotype 5420
    reproductive system phenotype 129
      abnormal reproductive system morphology 97
        abnormal gametogenesis 20
          abnormal spermatogenesis 16
            abnormal spermatid morphology 0
              abnormal manchette morphology 0
                abnormal manchette perinuclear ring morphology 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5420
    reproductive system phenotype 129
      abnormal reproductive system morphology 97
        abnormal gametogenesis 20
          abnormal germ cell morphology 11
            abnormal male germ cell morphology 4
              abnormal spermatid morphology 0
                abnormal manchette morphology 0
                  abnormal manchette perinuclear ring morphology 0
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