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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:reactive type II pneumocyte hyperplasia
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Accession:MP:0031238 term browser browse the term
Definition:alteration to type II pneumocytes following lung injury that results in increased numbers of these cells occurring in clusters and having morphological alterations including: cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin
Comment:reactive type II pneumocyte hyperplasia develops as a response to alveolar injury in various pulmonary disorders, esp. in the setting of inflammation and interstitial fibrosis and during the healing phase of diffuse alveolar damage
Synonyms:exact_synonym: reactive alveolar type II cell hyperplasia
 narrow_synonym: Type II pneumocyte hyperplasia
 xref: HP:0033328

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Path 1
Term Annotations click to browse term
  mammalian phenotype 0
    respiratory system phenotype 0
      abnormal respiratory system morphology 0
        abnormal lung morphology 0
          abnormal lung epithelium morphology 0
            abnormal pulmonary alveolus epithelium morphology 0
              abnormal pulmonary alveolus epithelial cell morphology 0
                abnormal type II pneumocyte morphology 0
                  increased type II pneumocyte number 0
                    reactive type II pneumocyte hyperplasia 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 0
    respiratory system phenotype 0
      abnormal respiratory system morphology 0
        abnormal lung morphology 0
          abnormal pulmonary alveolar system morphology 0
            abnormal pulmonary acinus morphology 0
              abnormal pulmonary alveolus morphology 0
                abnormal pulmonary alveolus epithelium morphology 0
                  abnormal pulmonary alveolus epithelial cell morphology 0
                    abnormal type II pneumocyte morphology 0
                      increased type II pneumocyte number 0
                        reactive type II pneumocyte hyperplasia 0
paths to the root