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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:reactive type II pneumocyte hyperplasia
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Accession:MP:0031238 term browser browse the term
Definition:alteration to type II pneumocytes following lung injury that results in increased numbers of these cells occurring in clusters and having morphological alterations including: cuboidal shapes, increased nucleocytoplasmic ratio, enlarged nuclei, prominent nucleoli, and various alterations in their nuclear chromatin
Comment:reactive type II pneumocyte hyperplasia develops as a response to alveolar injury in various pulmonary disorders, esp. in the setting of inflammation and interstitial fibrosis and during the healing phase of diffuse alveolar damage
Synonyms:exact_synonym: reactive alveolar type II cell hyperplasia
 narrow_synonym: Type II pneumocyte hyperplasia
 xref: HP:0033328


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reactive type II pneumocyte hyperplasia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Copa coatomer protein complex subunit alpha IAGP MGI PMID:32198142 NCBI chr 1:171,909,885...171,949,899
Ensembl chr 1:171,910,096...171,949,897 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 17065
    respiratory system phenotype 1888
      abnormal respiratory system morphology 1302
        abnormal lung morphology 973
          abnormal lung epithelium morphology 161
            abnormal pulmonary alveolus epithelium morphology 100
              abnormal pulmonary alveolus epithelial cell morphology 96
                abnormal type II pneumocyte morphology 82
                  increased type II pneumocyte number 23
                    reactive type II pneumocyte hyperplasia 1
Path 2
Term Annotations click to browse term
  mammalian phenotype 17065
    respiratory system phenotype 1888
      abnormal respiratory system morphology 1302
        abnormal lung morphology 973
          abnormal pulmonary alveolar system morphology 379
            abnormal pulmonary acinus morphology 365
              abnormal pulmonary alveolus morphology 326
                abnormal pulmonary alveolus epithelium morphology 100
                  abnormal pulmonary alveolus epithelial cell morphology 96
                    abnormal type II pneumocyte morphology 82
                      increased type II pneumocyte number 23
                        reactive type II pneumocyte hyperplasia 1
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