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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal angiotensin II level
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Accession:MP:0031227 term browser browse the term
Definition:any anomaly in the concentration of angiotensin II, a vasoactive octapeptide produced by the action of angiotensin-converting enzyme on angiotensin I; it acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone



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  mammalian phenotype 5314
    homeostasis/metabolism phenotype 1367
      abnormal homeostasis 1274
        abnormal hormone level 309
          abnormal angiotensin II level 0
            abnormal circulating angiotensin II level + 0
            decreased angiotensin II level + 0
            increased angiotensin II level + 0
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