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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal histamine level
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Accession:MP:0030754 term browser browse the term
Definition:anomaly in the amount of histamine, an amine derived from the decarboxylation of histidine that is involved in local immune responses, in regulating physiological function in the gut, and that acts as a neurotransmitter for the brain, spinal cord, and uterus; histamine is involved in the inflammatory response and has a central role as a mediator of itching


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abnormal circulating histamine level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kit KIT proto-oncogene receptor tyrosine kinase IAGP MGI PMID:23624557 NCBI chr 5:75,735,647...75,817,382
Ensembl chr 5:75,735,576...75,817,382 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 IAGP MGI PMID:12151598 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
decreased circulating histamine level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab44 RAB44, member RAS oncogene family IAGP MGI PMID:32238914 NCBI chr17:29,333,102...29,367,966
Ensembl chr17:29,333,119...29,367,954 		JBrowse link
decreased histamine level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp9 matrix metallopeptidase 9 IAGP MGI PMID:16684893 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Prss57 protease, serine 57 IAGP MGI PMID:33214666 NCBI chr10:79,617,308...79,630,523
Ensembl chr10:79,617,308...79,626,795 		JBrowse link
increased circulating histamine level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rabgef1 RAB guanine nucleotide exchange factor (GEF) 1 IAGP MGI PMID:15235600 NCBI chr 5:130,200,644...130,243,178
Ensembl chr 5:130,200,639...130,243,183 		JBrowse link
increased histamine level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnmt histamine N-methyltransferase IAGP MGI PMID:29162912 NCBI chr 2:23,892,923...23,939,756
Ensembl chr 2:23,892,922...23,939,406 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 16438
    homeostasis/metabolism phenotype 7531
      abnormal homeostasis 6701
        abnormal histamine physiology 9
          abnormal histamine level 7
            abnormal circulating histamine level + 4
            decreased histamine level + 3
            increased histamine level + 2
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