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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal manganese homeostasis
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Accession:MP:0030592 term browser browse the term
Definition:anomaly in the processes involved in the maintenance of an internal steady state of manganese ions within an organism or cell; manganese ions function as cofactors for a large variety of enzymes with many functions; while the element is a required trace mineral for all known living organisms, it also acts as a neurotoxin in larger amounts
Synonyms:exact_synonym: abnormal manganese ion homeostasis


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increased circulating manganese level term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cp ceruloplasmin IMP RGD PMID:31560858 RGD:38549582 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075 		JBrowse link
G Cpem1Ang ceruloplasmin; CRISPR/Cas9 induced mutant1, Ang IMP RGD PMID:31560858 RGD:38549582
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  mammalian phenotype 5373
    homeostasis/metabolism phenotype 1397
      abnormal homeostasis 1299
        abnormal mineral homeostasis 53
          abnormal manganese homeostasis 3
            abnormal manganese level + 3
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