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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal enamel development
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Accession:MP:0030544 term browser browse the term
Definition:any anomaly in the process whose specific outcome is the formation of dental enamel, the hard outer coating of the exposed portion of the tooth; amelogenesis occurs after the first establishment of dentin, via cells known as ameloblasts, and can generally be divided into two broad stages: (i) a secretory stage that involves proteins and an organic matrix forming a partially mineralized enamel and (ii) a maturation stage which completes enamel mineralization
Synonyms:exact_synonym: abnormal amelogenesis;   abnormal enamel formation



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abnormal enamel development term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf6 interferon regulatory factor 6 IAGP MGI PMID:27369589 NCBI chr 1:192,835,420...192,854,344
Ensembl chr 1:192,835,419...192,854,331
JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 IAGP MGI PMID:27369589 NCBI chr 3:128,993,527...129,013,243
Ensembl chr 3:128,993,527...129,013,240
JBrowse link
G Sp3 trans-acting transcription factor 3 IAGP MGI PMID:10675334 NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790
JBrowse link
G Tnn tenascin N IAGP MGI PMID:33552067 NCBI chr 1:159,912,599...159,981,242
Ensembl chr 1:159,912,599...159,981,150
JBrowse link
abnormal ameloblast differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl11b B cell leukemia/lymphoma 11B IAGP MGI PMID:19251658 NCBI chr12:107,876,662...107,970,404
Ensembl chr12:107,876,662...107,969,861
JBrowse link
G Hras Harvey rat sarcoma virus oncogene IAGP MGI PMID:24057668 NCBI chr 7:140,769,847...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Irx1 Iroquois homeobox 1 IAGP MGI PMID:28746823 NCBI chr13:72,106,351...72,111,842
Ensembl chr13:72,106,040...72,111,842
JBrowse link
G Prrx1 paired related homeobox 1 IAGP MGI PMID:9876178 NCBI chr 1:163,072,688...163,142,714
Ensembl chr 1:163,072,688...163,141,279
JBrowse link
G Prrx2 paired related homeobox 2 IAGP MGI PMID:9876178 NCBI chr 2:30,735,076...30,771,263
Ensembl chr 2:30,724,984...30,771,263
JBrowse link
G Rnf146 ring finger protein 146 IAGP MGI PMID:28581440 NCBI chr10:29,220,172...29,238,438
Ensembl chr10:29,220,172...29,238,438
JBrowse link
G Tnn tenascin N IAGP MGI PMID:33552067 NCBI chr 1:159,912,599...159,981,242
Ensembl chr 1:159,912,599...159,981,150
JBrowse link
abnormal ameloblast morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ambn ameloblastin IAGP MGI PMID:15583034 NCBI chr 5:88,603,850...88,616,390
Ensembl chr 5:88,603,850...88,616,390
JBrowse link
G Amelx amelogenin, X-linked IAGP MGI PMID:16707492 PMID:20067920 NCBI chr  X:167,959,110...167,970,205
Ensembl chr  X:167,959,110...167,970,196
JBrowse link
G Amtn amelotin IAGP MGI PMID:25715379 NCBI chr 5:88,523,967...88,533,775
Ensembl chr 5:88,523,967...88,533,775
JBrowse link
G Bcl11b B cell leukemia/lymphoma 11B IAGP MGI PMID:19251658 PMID:23727454 NCBI chr12:107,876,662...107,970,404
Ensembl chr12:107,876,662...107,969,861
JBrowse link
G Enam enamelin IAGP MGI PMID:24603688 NCBI chr 5:88,635,834...88,653,908
Ensembl chr 5:88,635,834...88,653,908
JBrowse link
G Evc2 EvC ciliary complex subunit 2 IAGP MGI PMID:26219237 NCBI chr 5:37,495,801...37,582,399
Ensembl chr 5:37,495,843...37,582,399
JBrowse link
G Fam20a FAM20A, golgi associated secretory pathway pseudokinase IAGP MGI PMID:22732358 NCBI chr11:109,563,752...109,613,989
Ensembl chr11:109,560,575...109,613,105
JBrowse link
G Hras Harvey rat sarcoma virus oncogene IAGP MGI PMID:19416908 PMID:24057668 NCBI chr 7:140,769,847...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Irf6 interferon regulatory factor 6 IAGP MGI PMID:27369589 NCBI chr 1:192,835,420...192,854,344
Ensembl chr 1:192,835,419...192,854,331
JBrowse link
G Lama3 laminin, alpha 3 IAGP MGI PMID:10366601 NCBI chr18:12,466,806...12,716,070
Ensembl chr18:12,466,876...12,716,070
JBrowse link
G Mmp20 matrix metallopeptidase 20 (enamelysin) IAGP MGI PMID:12393861 NCBI chr 9:7,628,232...7,674,969
Ensembl chr 9:7,628,232...7,674,980
JBrowse link
G Nectin1 nectin cell adhesion molecule 1 IAGP MGI PMID:18703497 PMID:21038445 NCBI chr 9:43,655,251...43,718,758
Ensembl chr 9:43,655,281...43,743,955
JBrowse link
G Nectin3 nectin cell adhesion molecule 3 IAGP MGI PMID:21038445 NCBI chr16:46,208,028...46,318,898
Ensembl chr16:46,208,069...46,318,888
JBrowse link
G Odaph odontogenesis associated phosphoprotein IAGP MGI PMID:33772937 NCBI chr 5:92,135,332...92,143,176
Ensembl chr 5:92,135,334...92,143,179
JBrowse link
G Pax9 paired box 9 IAGP MGI PMID:16236760 NCBI chr12:56,738,478...56,759,609
Ensembl chr12:56,738,552...56,759,607
JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 IAGP MGI PMID:27369589 NCBI chr 3:128,993,527...129,013,243
Ensembl chr 3:128,993,527...129,013,240
JBrowse link
G Postn periostin, osteoblast specific factor IAGP MGI PMID:16314533 PMID:16497272 NCBI chr 3:54,266,688...54,298,462
Ensembl chr 3:54,268,530...54,298,458
JBrowse link
G Prrx1 paired related homeobox 1 IAGP MGI PMID:9876178 NCBI chr 1:163,072,688...163,142,714
Ensembl chr 1:163,072,688...163,141,279
JBrowse link
G Prrx2 paired related homeobox 2 IAGP MGI PMID:9876178 NCBI chr 2:30,735,076...30,771,263
Ensembl chr 2:30,724,984...30,771,263
JBrowse link
G Pthlh parathyroid hormone-like peptide IAGP MGI PMID:9391087 PMID:9751753 NCBI chr 6:147,153,607...147,165,511
Ensembl chr 6:147,153,599...147,165,681
JBrowse link
G Shh sonic hedgehog IAGP MGI PMID:11044393 NCBI chr 5:28,661,838...28,672,099
Ensembl chr 5:28,661,813...28,672,254
JBrowse link
G Smo smoothened, frizzled class receptor IAGP MGI PMID:12403705 NCBI chr 6:29,735,496...29,761,365
Ensembl chr 6:29,735,502...29,761,364
JBrowse link
G Sp3 trans-acting transcription factor 3 IAGP MGI PMID:10675334 NCBI chr 2:72,766,774...72,810,790
Ensembl chr 2:72,766,771...72,810,790
JBrowse link
G Sp6 trans-acting transcription factor 6 IAGP MGI PMID:18297738 NCBI chr11:96,904,395...96,915,565
Ensembl chr11:96,904,220...96,915,560
JBrowse link
G Wdr72 WD repeat domain 72 IAGP MGI PMID:25008349 NCBI chr 9:74,017,613...74,190,485
Ensembl chr 9:74,017,638...74,190,590
JBrowse link
abnormal enamel mineralization term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amelx amelogenin, X-linked IAGP MGI PMID:20067920 NCBI chr  X:167,959,110...167,970,205
Ensembl chr  X:167,959,110...167,970,196
JBrowse link
G Amtn amelotin IAGP MGI PMID:25715379 NCBI chr 5:88,523,967...88,533,775
Ensembl chr 5:88,523,967...88,533,775
JBrowse link
G Cnnm4 cyclin M4 IAGP MGI PMID:24339795 NCBI chr 1:36,510,678...36,547,857
Ensembl chr 1:36,510,701...36,547,845
JBrowse link
G Enam enamelin IAGP MGI PMID:18252720 NCBI chr 5:88,635,834...88,653,908
Ensembl chr 5:88,635,834...88,653,908
JBrowse link
G Hras Harvey rat sarcoma virus oncogene IAGP MGI PMID:19416908 PMID:24057668 NCBI chr 7:140,769,847...140,773,938
Ensembl chr 7:140,769,018...140,773,918
JBrowse link
G Irf6 interferon regulatory factor 6 IAGP MGI PMID:27369589 NCBI chr 1:192,835,420...192,854,344
Ensembl chr 1:192,835,419...192,854,331
JBrowse link
G Nectin1 nectin cell adhesion molecule 1 IAGP MGI PMID:18703497 NCBI chr 9:43,655,251...43,718,758
Ensembl chr 9:43,655,281...43,743,955
JBrowse link
G Odaph odontogenesis associated phosphoprotein IAGP MGI PMID:33772937 NCBI chr 5:92,135,332...92,143,176
Ensembl chr 5:92,135,334...92,143,179
JBrowse link
G Pitx2 paired-like homeodomain transcription factor 2 IAGP MGI PMID:27369589 NCBI chr 3:128,993,527...129,013,243
Ensembl chr 3:128,993,527...129,013,240
JBrowse link
G Relt RELT tumor necrosis factor receptor IAGP MGI PMID:30506946 NCBI chr 7:100,495,054...100,512,690
Ensembl chr 7:100,495,054...100,512,653
JBrowse link
G Slc24a4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 IAGP MGI PMID:23375655 NCBI chr12:102,094,986...102,233,392
Ensembl chr12:102,094,992...102,233,350
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II IAGP MGI PMID:24278477 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428
JBrowse link
G Tnn tenascin N IAGP MGI PMID:33552067 NCBI chr 1:159,912,599...159,981,242
Ensembl chr 1:159,912,599...159,981,150
JBrowse link
G Wdr72 WD repeat domain 72 IAGP MGI PMID:25008349 NCBI chr 9:74,017,613...74,190,485
Ensembl chr 9:74,017,638...74,190,590
JBrowse link
absent Tomes' process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enam enamelin IAGP MGI PMID:24603688 NCBI chr 5:88,635,834...88,653,908
Ensembl chr 5:88,635,834...88,653,908
JBrowse link
G Smo smoothened, frizzled class receptor IAGP MGI PMID:12403705 NCBI chr 6:29,735,496...29,761,365
Ensembl chr 6:29,735,502...29,761,364
JBrowse link
ameloblast degeneration term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) IAGP MGI PMID:21051554 NCBI chr 2:26,483,069...26,494,429
Ensembl chr 2:26,483,069...26,494,429
JBrowse link
G Msx2 msh homeobox 2 IAGP MGI PMID:10742104 NCBI chr13:53,620,917...53,626,816
Ensembl chr13:53,620,920...53,627,110
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 IAGP MGI PMID:15265007 NCBI chr 2:75,505,857...75,535,007
Ensembl chr 2:75,505,857...75,534,985
JBrowse link
G Tgfb1 transforming growth factor, beta 1 IAGP MGI PMID:24056369 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502
JBrowse link
short Tomes' process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amelx amelogenin, X-linked IAGP MGI PMID:16707492 NCBI chr  X:167,959,110...167,970,205
Ensembl chr  X:167,959,110...167,970,196
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16233
    craniofacial phenotype 1570
      abnormal craniofacial morphology 1570
        abnormal craniofacial development 509
          abnormal tooth development 126
            abnormal enamel development 36
              abnormal ameloblast morphology + 32
              abnormal enamel mineralization 14
Path 2
Term Annotations click to browse term
  mammalian phenotype 16233
    skeleton phenotype 3196
      abnormal skeleton morphology 3012
        abnormal axial skeleton morphology 1719
          abnormal craniofacial bone morphology 995
            abnormal cranium morphology 979
              abnormal viscerocranium morphology 721
                abnormal jaw morphology 651
                  abnormal dental arch morphology 338
                    abnormal tooth morphology 337
                      abnormal tooth hard tissue morphology 71
                        abnormal enamel morphology 54
                          abnormal enamel development 36
                            abnormal ameloblast morphology + 32
                            abnormal enamel mineralization 14
paths to the root