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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:increased endoplasmic reticulum stress
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Accession:MP:0020354 term browser browse the term
Definition:increase in in the accumulation of misfolded or unfolded proteins in the endoplasmic reticulum lumen; this accumulation may be stimulated by genetic or enviromental factors
Synonyms:exact_synonym: increased ER stress

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increased endoplasmic reticulum stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tg thyroglobulin IAGP DNA:missense mutation:cds:p.G2320R (rat) RGD PMID:11089535 RGD:730133 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Tgrdw thyroglobulin; rdw mutant IAGP compared to wild type and heterozygotes RGD PMID:11089535 RGD:730133
G Wfs1 wolframin ER transmembrane glycoprotein onset
IMP RGD PMID:28860598 PMID:29976929 RGD:149735331, RGD:150519890 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602
JBrowse link
G Wfs1em1Ptsn wolframin ER transmembrane glycoprotein; ZFN induced mutant 1 onset
IMP RGD PMID:28860598 PMID:29976929 RGD:149735331, RGD:150519890

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  mammalian phenotype 5374
    cellular phenotype 175
      abnormal cell physiology 139
        abnormal endoplasmic reticulum physiology 6
          abnormal endoplasmic reticulum stress 6
            increased endoplasmic reticulum stress 6
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