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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:increased susceptibility to malignant hyperthermia
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Accession:MP:0020214 term browser browse the term
Definition:increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine
Synonyms:exact_synonym: susceptible to malignant hyperpyrexia;   susceptible to malignant hyperthermia susceptibility;   susceptible to malignant hyperthermia syndrome


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increased susceptibility to malignant hyperthermia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htt huntingtin IAGP MGI PMID:11709539 NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878 		JBrowse link
G Ryr1 ryanodine receptor 1, skeletal muscle IAGP MGI PMID:17122579 PMID:22139840 PMID:30236258 PMID:34257294 NCBI chr 7:28,702,765...28,824,599
Ensembl chr 7:28,702,769...28,824,604 		JBrowse link
Term paths to the root
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  mammalian phenotype 16239
    homeostasis/metabolism phenotype 7359
      abnormal homeostasis 6528
        abnormal adaptive thermogenesis 129
          increased susceptibility to malignant hyperthermia 2
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