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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:decreased circulating hormone level
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Accession:MP:0014457 term browser browse the term
Definition:reduction in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organ
Synonyms:exact_synonym: reduced circulating hormone concentration


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decreased circulating adrenocorticotropin level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp4 dipeptidylpeptidase 4 IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422 		JBrowse link
G Dpp4DPPIV dipeptidylpeptidase 4; DPPIV mutant IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336
decreased circulating aldosterone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cfb complement factor B IMP compared to wild type SHR RGD PMID:28739975 RGD:127285403 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740 		JBrowse link
G Cfbem1Tja complement factor B, ZFN induced mutant 1, Tja IMP compared to wild type SHR RGD PMID:28739975 RGD:127285403
G Kcnj16 potassium inwardly-rectifying channel, subfamily J, member 16 IMP compared to SS/JrHsdMcwi RGD PMID:28931751 RGD:38500204 NCBI chr10:96,489,329...96,520,745
Ensembl chr10:96,460,331...96,566,075 		JBrowse link
G Kcnj16em1Mcwi potassium inwardly-rectifying channel, subfamily J, member 16; zinc finger nuclease induced mutant 1, Medical College of Wisconsin IMP compared to SS/JrHsdMcwi RGD PMID:28931751 RGD:38500204
decreased circulating anti-Mullerian hormone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor IMP RGD PMID:34256052 RGD:405878088 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Ahrem1Soar aryl hydrocarbon receptor; CRISPR/Cas9 induced mutant1, Soar IMP RGD PMID:34256052 RGD:405878088
decreased circulating corticosterone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp4 dipeptidylpeptidase 4 IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336 NCBI chr 3:67,370,794...67,452,422
Ensembl chr 3:67,370,804...67,452,422 		JBrowse link
G Dpp4DPPIV dipeptidylpeptidase 4; DPPIV mutant IAGP compared to DA/Ztm RGD PMID:19327106 RGD:41408336
G Tspo translocator protein induces IMP RGD PMID:29074640 RGD:150429771 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460 		JBrowse link
G Tspoem1Vpl translocator protein; ZFN induced mutant1, Vpl induces IMP RGD PMID:29074640 RGD:150429771
G Tspoem2Vpl translocator protein; ZFN induced mutant2, Vpl induces IMP RGD PMID:29074640 RGD:150429771
decreased circulating estradiol level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone IDA RGD PMID:12450317 RGD:704424 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:28520870 RGD:38548924 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Esr2em1Soar estrogen receptor 2; ZFN induced mutant 1, Soar IMP RGD PMID:28520870 RGD:38548924
decreased circulating follicle stimulating hormone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 IMP RGD PMID:28520870 RGD:38548924 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Esr2em1Soar estrogen receptor 2; ZFN induced mutant 1, Soar IMP RGD PMID:28520870 RGD:38548924
G Wwox WW domain-containing oxidoreductase IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974 NCBI chr19:59,338,402...60,269,323
Ensembl chr19:59,341,233...60,269,441 		JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974
decreased circulating growth hormone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ghsr growth hormone secretagogue receptor IMP DNA:missense mutation:cds:nucleotide 1027 RGD PMID:27129673 RGD:150520013 NCBI chr 2:112,196,158...112,201,666
Ensembl chr 2:112,196,767...112,201,181 		JBrowse link
G Ghsrm1Mcwi growth hormone secretagogue receptor; mutation 1, Medical College of Wisconsin IMP compared to wild type rats in response to ghrelin (CHEBI:75431) RGD PMID:27129673 RGD:150520013
decreased circulating insulin level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gja8 gap junction protein, alpha 8 IAGP RGD PMID:27871290 RGD:150429989 NCBI chr 2:187,179,668...187,181,284
Ensembl chr 2:187,175,507...187,186,167 		JBrowse link
G Gja8m1Cub gap junction protein, alpha 8; mutant 1 Cub IAGP RGD PMID:27871290 RGD:150429989
G Tbc1d1 TBC1 domain family member 1 induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607 NCBI chr14:44,289,241...44,489,246
Ensembl chr14:44,289,241...44,488,167 		JBrowse link
G Tbc1d1Tn(sb)1Fkh TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607
decreased circulating insulin-like growth factor I level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator IMP RGD PMID:29190650 RGD:151347176 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643 		JBrowse link
G Cftrem1Sage cystic fibrosis transmembrane conductance regulator; ZFN induced mutant 1 Sage IMP RGD PMID:29190650 RGD:151347176
decreased circulating leptin level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bscl2 BSCL2 lipid droplet biogenesis associated, seipin IMP RGD PMID:25934999 RGD:11085488 NCBI chr 1:215,160,764...215,172,540
Ensembl chr 1:215,160,957...215,172,536 		JBrowse link
G Bscl2m1Kyo BSCL2, seipin lipid droplet biogenesis associated; ENU induced mutant1, Kyo IMP RGD PMID:25934999 RGD:11085488
G Ghsr growth hormone secretagogue receptor IMP RGD PMID:19931319 RGD:12910109 NCBI chr 2:112,196,158...112,201,666
Ensembl chr 2:112,196,767...112,201,181 		JBrowse link
G Pmch pro-melanin-concentrating hormone IMP compared to wild-type RGD PMID:23555928 PMID:19934402 RGD:150429944, RGD:150429945 NCBI chr 7:24,399,404...24,400,720
Ensembl chr 7:24,399,404...24,400,720 		JBrowse link
G Pmchm1Hubr pro-melanin-concentrating hormone; ENU induced mutant1, Hubr IMP compared to wild-type RGD PMID:23555928 PMID:19934402 RGD:150429944, RGD:150429945
decreased circulating levels of thyroid hormone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tg thyroglobulin IAGP RGD PMID:10760744 RGD:13605608 NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:100,307,349...100,314,539
Ensembl chr 7:100,307,349...100,314,539 		JBrowse link
G Tgrdw thyroglobulin; rdw mutant IAGP RGD PMID:10760744 RGD:13605608
decreased circulating luteinizing hormone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr2 estrogen receptor 2 IMP RGD PMID:28520870 RGD:38548924 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Esr2em1Soar estrogen receptor 2; ZFN induced mutant 1, Soar IMP RGD PMID:28520870 RGD:38548924
G Kiss1 KiSS-1 metastasis-suppressor IMP RGD PMID:25582792 RGD:10059342 NCBI chr13:47,327,159...47,332,759
Ensembl chr13:47,327,004...47,332,906 		JBrowse link
G Kiss1tm1Nips KiSS-1 metastasis-suppressor; targeted mutant 1, Nips IMP RGD PMID:25582792 RGD:10059342
G Wwox WW domain-containing oxidoreductase IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974 NCBI chr19:59,338,402...60,269,323
Ensembl chr19:59,341,233...60,269,441 		JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974
decreased circulating progesterone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone IDA RGD PMID:12450317 RGD:704424 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386 		JBrowse link
G Esr2 estrogen receptor 2 IMP RGD PMID:29580824 RGD:38548925 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G Esr2em1Soar estrogen receptor 2; ZFN induced mutant 1, Soar IMP compared to wild type RGD PMID:29580824 RGD:38548925
decreased circulating prolactin level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:23799078 RGD:13462048 NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:124,706,080...124,867,239 		JBrowse link
G Lrrk2em1Sage leucine-rich repeat kinase 2; zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs IMP RGD PMID:23799078 RGD:13462048
decreased circulating testosterone level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhh desert hedgehog signaling molecule IMP RGD PMID:21062903 RGD:38548923 NCBI chr 7:131,929,857...131,935,352
Ensembl chr 7:131,929,857...131,935,352 		JBrowse link
G Tspo translocator protein IMP RGD PMID:29074640 RGD:150429771 NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:116,600,210...116,610,460 		JBrowse link
G Tspoem1Vpl translocator protein; ZFN induced mutant1, Vpl IMP RGD PMID:29074640 RGD:150429771
G Tspoem2Vpl translocator protein; ZFN induced mutant2, Vpl IMP RGD PMID:29074640 RGD:150429771
G Wwox WW domain-containing oxidoreductase IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974 NCBI chr19:59,338,402...60,269,323
Ensembl chr19:59,341,233...60,269,441 		JBrowse link
G Wwoxlde WW domain-containing oxidoreductase; lde mutant IAGP compared to wild type and heterozygotes RGD PMID:18676360 RGD:150429974
decreased circulating thyroxine level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tshr thyroid stimulating hormone receptor IMP RGD PMID:29507327 RGD:150521601 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010 		JBrowse link
G Tshrem1Mlit thyroid stimulating hormone receptor; CRISPR/Cas9 induced mutant 1, Mlit IMP RGD PMID:29507327 RGD:150521601
decreased circulating triiodothyronine level term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tshr thyroid stimulating hormone receptor IMP RGD PMID:29507327 RGD:150521601 NCBI chr 6:116,072,321...116,206,009
Ensembl chr 6:116,072,281...116,206,010 		JBrowse link
G Tshrem1Mlit thyroid stimulating hormone receptor; CRISPR/Cas9 induced mutant 1, Mlit IMP RGD PMID:29507327 RGD:150521601
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5432
    homeostasis/metabolism phenotype 1429
      abnormal homeostasis 1330
        abnormal hormone level 324
          abnormal circulating hormone level 293
            decreased circulating hormone level 85
              decreased circulating adrenaline level 0
              decreased circulating angiotensin II level 0
              decreased circulating anti-Mullerian hormone level 3
              decreased circulating antidiuretic hormone level 1
              decreased circulating atrial natriuretic factor 0
              decreased circulating dihydrotestosterone level 0
              decreased circulating erythropoietin level 0
              decreased circulating estrogen level + 5
              decreased circulating gastric inhibitory polypeptide level 0
              decreased circulating gastrin level 0
              decreased circulating ghrelin level 0
              decreased circulating glucagon level 0
              decreased circulating glucocorticoid level + 13
              decreased circulating gonadotropin level + 16
              decreased circulating insulin level 23
              decreased circulating insulin-like growth factor I level 3
              decreased circulating leptin level 11
              decreased circulating levels of thyroid hormone + 6
              decreased circulating mineralocorticoid level + 6
              decreased circulating noradrenaline level 0
              decreased circulating osteocalcin level 0
              decreased circulating parathyroid hormone level 0
              decreased circulating pituitary hormone level + 22
              decreased circulating progesterone level 5
              decreased circulating testosterone level 10
paths to the root