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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal endocrine pancreas secretion
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Accession:MP:0014195 term browser browse the term
Definition:anomaly in the synthesis and/or release of any of the hormones produced by different types of cells in the islets of Langerhans of the endocrine pancreas and secreted directly into the blood stream to regulate blood glucose homeostasis; these hormones include glucagon secreted by alpha cells, insulin and amylin (also known as Islet Amyloid Polypeptide or IAPP) co-secreted by beta cells, somatostatin secreted by delta cells, gherlin secreted by epsilon cells, and pancreatic polypeptide secreted by PP cells (also known as F cells
Synonyms:exact_synonym: abnormal endocrine pancreatic secretion


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decreased insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc8 ATP binding cassette subfamily C member 8 IMP compared to wild type RGD PMID:30616503 RGD:150573710 NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510 		JBrowse link
G Abcc8em1Cgen ATP binding cassette subfamily C member 8; TALEN induced mutant 1, Cgen IMP compared to wild type RGD PMID:30616503 RGD:150573710
G Tbc1d1 TBC1 domain family member 1 induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607 NCBI chr14:43,936,820...44,135,133
Ensembl chr14:43,935,636...44,136,499 		JBrowse link
G Tbc1d1Tn(sb)1Fkh TBC1 domain family member 1; Sleeping Beauty induced mutant 1, Fkh induces IMP compared to Wild type RGD PMID:28177704 RGD:150521607
G Wfs1 wolframin ER transmembrane glycoprotein induces IMP RGD PMID:29976929 RGD:150519890 NCBI chr14:73,810,478...73,834,993
Ensembl chr14:73,810,404...73,835,602 		JBrowse link
G Wfs1em1Ptsn wolframin ER transmembrane glycoprotein; ZFN induced mutant 1 induces IMP RGD PMID:29976929 RGD:150519890
increased insulin secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glp1r glucagon-like peptide 1 receptor IDA RGD PMID:12093887 RGD:625448 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:23799078 RGD:13462048 NCBI chr 7:122,826,696...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  mammalian phenotype 5418
    endocrine/exocrine gland phenotype 394
      abnormal gland physiology 85
        abnormal pancreas physiology 67
          abnormal pancreas secretion 26
            abnormal endocrine pancreas secretion 26
              abnormal amylin secretion + 0
              abnormal glucagon secretion + 0
              abnormal insulin secretion + 26
              abnormal pancreatic ghrelin secretion 0
              abnormal pancreatic polypeptide secretion 0
              abnormal pancreatic somatostatin secretion 0
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