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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal tear film morphology
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Accession:MP:0014131 term browser browse the term
Definition:any alteration in the structure, biochemical composition, or stability of the thin acellular fluid layer that adheres to the most superficial layer of the corneal epithelium and lubricates and protects the ocular surface; the film is generally composed of three layers: (i) an inner mucous layer, secreted largely by the conjunctival goblet cells with contributions from the lacrimal glands, which coats the cornea, provides a hydrophobic layer, and allows for even distribution of the tear film; (ii) a middle aqueous layer, secreted by the lacrimal glands, which keeps the corneal surface moist, and provides a mechanism for oxygenation and nutrient exchange with the avascular anterior corneal tissue; and (iii) an outer lipid layer, secreted principally by the Meibomian (tarsal) glands although lipid tear elements also are contributed by the Harderian glands; tear film lipids form a monolayer on the tear surface, and function by enhancing the surface tension which supports the integrity of the tear film against collapse due to gravity and also slows down the loss of the tear film by evaporation; in addition , the lipid layer provides a glassy, smooth interface between the air and the transparent cornea
Synonyms:exact_synonym: abnormal precorneal film morphology



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abnormal tear film morphology term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Awat1 acyl-CoA wax alcohol acyltransferase 1 IAGP MGI PMID:34113821 NCBI chr  X:99,615,853...99,621,812
Ensembl chr  X:99,615,857...99,621,811
JBrowse link
G Awat2 acyl-CoA wax alcohol acyltransferase 2 IAGP MGI PMID:32851726 PMID:34113821 NCBI chr  X:99,445,827...99,537,885
Ensembl chr  X:99,445,827...99,486,323
JBrowse link
G Far2 fatty acyl CoA reductase 2 IAGP MGI PMID:35238077 NCBI chr 6:147,948,914...148,084,256
Ensembl chr 6:147,948,757...148,084,256
JBrowse link

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Term Annotations click to browse term
  mammalian phenotype 16979
    vision/eye phenotype 3151
      abnormal eye morphology 2991
        abnormal ocular surface morphology 93
          abnormal tear film morphology 3
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