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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:Lewy bodies
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Accession:MP:0014065 term browser browse the term
Definition:Intracytoplasmic eosinophilic neuronal inclusions seen especially in pigmented brainstem neurons and in the cortex; brainstem Lewy bodies consist of a dense core surrounded by a halo of 10-nm-wide radiating fibrils, the primary structural component of which is alpha-synuclein; cortical Lewy bodies are also composed of alpha-synuclein fibrils, but are less defined and lack halos; Lewy bodies are seen in Parkinson disease, Lewy body dementia and other forms of dementia
Synonyms:related_synonym: Lewy body dementia
 xref: EFO:0006792;   HP:0100315


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  mammalian phenotype 5440
    nervous system phenotype 386
      abnormal nervous system morphology 222
        nervous system inclusion bodies 10
          Lewy bodies 0
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