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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal mammary gland myoepithelium physiology
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Accession:MP:0013779 term browser browse the term
Definition:any functional anomaly of the outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane; basal cells (aka myoepithelial cells or MECs) are specialized epithelial cells that express smooth muscle-specific contractile and cytoskeletal properties; during lactation, MECs contract in response to oxytocin to generate the contractile force required for milk ejection; MECs are involved in all developmental stages of mammary gland morphogenesis, modulating proliferation and differentiation of luminal cells; they take part in the formation of extracellular matrix, synthesizing its components and secreting proteinases and their inhibitors; in addition, MECs are regarded as natural cancer suppressors: they secrete suppressor proteins limiting cancer growth, invasiveness, and neoangiogenesis; MECs are markedly resistant to malignant transformation and they are able to suppress the transformation of neighboring luminal cells
Synonyms:exact_synonym: abnormal mammary MEC physiology;   abnormal mammary epithelium basal cell layer physiology;   abnormal mammary epithelium basal cell physiology;   abnormal mammary myoepithelial cell physiology;   abnormal mammary myoepithelium physiology


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Path 1
Term Annotations click to browse term
  mammalian phenotype 1
    integument phenotype 0
      abnormal skin adnexa physiology 0
        abnormal mammary gland physiology 0
          abnormal mammary gland epithelium physiology 0
            abnormal mammary gland myoepithelium physiology 0
              decreased mammary myoepithelial cell contraction 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 1
    endocrine/exocrine gland phenotype 0
      abnormal gland physiology 0
        abnormal exocrine gland physiology 0
          abnormal apocrine gland physiology 0
            abnormal mammary gland physiology 0
              abnormal mammary gland epithelium physiology 0
                abnormal mammary gland myoepithelium physiology 0
                  decreased mammary myoepithelial cell contraction 0
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