abnormal mammary gland myoepithelium physiology - Ontology Report

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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:	abnormal mammary gland myoepithelium physiology	go back to main search page
Accession:	MP:0013779	browse the term
Definition:	any functional anomaly of the outer cell layer of the mammary gland epithelium bilayer which is located basal to the luminal (secretory) cells and adjacent to the basement membrane; basal cells (aka myoepithelial cells or MECs) are specialized epithelial cells that express smooth muscle-specific contractile and cytoskeletal properties; during lactation, MECs contract in response to oxytocin to generate the contractile force required for milk ejection; MECs are involved in all developmental stages of mammary gland morphogenesis, modulating proliferation and differentiation of luminal cells; they take part in the formation of extracellular matrix, synthesizing its components and secreting proteinases and their inhibitors; in addition, MECs are regarded as natural cancer suppressors: they secrete suppressor proteins limiting cancer growth, invasiveness, and neoangiogenesis; MECs are markedly resistant to malignant transformation and they are able to suppress the transformation of neighboring luminal cells
Synonyms:	exact_synonym:	abnormal mammary MEC physiology; abnormal mammary epithelium basal cell layer physiology; abnormal mammary epithelium basal cell physiology; abnormal mammary myoepithelial cell physiology; abnormal mammary myoepithelium physiology

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Genes (1)

Symbol

Object Name

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Mrtfa

myocardin related transcription factor A

NCBI chr15:80,896,482...81,074,937
Ensembl chr15:80,896,482...81,074,958

Term paths to the root

Path 1
Term	Annotations
mammalian phenotype	16965
integument phenotype	2836
abnormal skin adnexa physiology	244
abnormal mammary gland physiology	120
abnormal mammary gland epithelium physiology	32
abnormal mammary gland myoepithelium physiology	1
decreased mammary myoepithelial cell contraction	0
Path 2
Term	Annotations
mammalian phenotype	16965
endocrine/exocrine gland phenotype	3450
abnormal gland physiology	923
abnormal exocrine gland physiology	265
abnormal apocrine gland physiology	120
abnormal mammary gland physiology	120
abnormal mammary gland epithelium physiology	32
abnormal mammary gland myoepithelium physiology	1
decreased mammary myoepithelial cell contraction	0

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