Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal fetal Leydig cell differentiation
go back to main search page
Accession:MP:0013603 term browser browse the term
Definition:atypical formation of or inability to produce the first or fetal population of Leydig cells (FLCs); in mice, FLCs arise in the testicular interstitium between E12.5 and E13.0, approximately 1 day after the appearance of Sertoli cells; Sertoli cells trigger differentiation of steroidogenic factor 1-positive (SF1-positive) progenitor cells into FLCs via paracrine regulation; the intercellular Notch signaling pathway is also involved in FLC establishment and maintenance; the FLC population increases dramatically during embryonic development despite the fact that differentiating FLCs are mitotically inactive, suggesting that expansion of FLC populations results from differentiation of progenitor cells, rather than cell division of existing FLCs; the SF1-positive cells in gonadal primordia are the primary source of FLCs but other sources such as neighboring mesonephros, migrating neural crest cells, and cells from the coelomic epithelium or interstitium are potential contributors also; at the end of fetal life and during the first 2 postnatal weeks in rodents, FLCs are gradually replaced by adult Leydig cells (ALCs)
Synonyms:exact_synonym: abnormal FLC differentiation;   abnormal foetal Leydig cell differentiation



show annotations for term's descendants           Sort by:
 
abnormal fetal Leydig cell differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhh desert hedgehog signaling molecule IMP RGD PMID:21062903 RGD:38548923 NCBI chr 7:130,050,910...130,056,406
Ensembl chr 7:130,050,910...130,056,406
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5368
    reproductive system phenotype 129
      abnormal reproductive system morphology 97
        abnormal sex gland morphology 67
          abnormal male reproductive gland morphology 58
            abnormal testis morphology 46
              abnormal testis interstitial tissue morphology 5
                abnormal Leydig cell morphology 5
                  abnormal Leydig cell differentiation 2
                    abnormal fetal Leydig cell differentiation 2
Path 2
Term Annotations click to browse term
  mammalian phenotype 5368
    reproductive system phenotype 129
      abnormal reproductive system morphology 97
        abnormal male reproductive system morphology 66
          abnormal male genitalia morphology 66
            abnormal internal male genitalia morphology 58
              abnormal testis morphology 46
                abnormal testis interstitial tissue morphology 5
                  abnormal Leydig cell morphology 5
                    abnormal Leydig cell differentiation 2
                      abnormal fetal Leydig cell differentiation 2
paths to the root