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The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories ( For more information about these ontologies, see the MGI Publications Page at

Term:abnormal circumventricular organ morphology
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Accession:MP:0013562 term browser browse the term
Definition:any structural abnormality of any of the secretory or sensory organs located in the brain region around or in relation to the ventricular system that are characterized by extensive vasculature and a lack of a normal blood brain barrier (BBB) and allow for the linkage between the central nervous system and peripheral blood flow; CVOs contain neural tissue and are an integral part of neuroendocrine function; all of the CVOs, besides the subcommissural organ, contain extensive vasculature and fenestrated capillaries which leads to a leaky BBB at the site of the organs; the lack of a BBB allows CVOs to act as an alternative route for peptides and hormones in the neural tissue to the peripheral blood stream, while still protecting it from toxic substances
Synonyms:exact_synonym: abnormal CVO morphology;   abnormal circumventricular organ of neuraxis morphology

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  mammalian phenotype 5402
    nervous system phenotype 368
      abnormal nervous system morphology 215
        abnormal brain morphology 139
          abnormal circumventricular organ morphology 0
            abnormal secretory circumventricular organ morphology + 0
            abnormal sensory circumventricular organ morphology + 0
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