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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.

Term:abnormal Langerhans cell number
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Accession:MP:0013411 term browser browse the term
Definition:anomaly in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus



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decreased Langerhans cell number term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:30249809 RGD:41404725 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Csf1rtm(EGFP)Tset colony stimulating factor 1 receptor; target mutant, Tset IMP RGD PMID:30249809 RGD:41404725

Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 5400
    immune system phenotype 499
      abnormal immune system morphology 191
        abnormal immune system cell morphology 151
          abnormal professional antigen presenting cell morphology 36
            abnormal dendritic cell morphology 3
              abnormal myeloid dendritic cell morphology 3
                abnormal Langerhans cell morphology 3
                  abnormal Langerhans cell number 3
                    decreased Langerhans cell number + 3
                    increased Langerhans cell number 0
Path 2
Term Annotations click to browse term
  mammalian phenotype 5400
    hematopoietic system phenotype 247
      abnormal hematopoietic system morphology/development 227
        abnormal hematopoietic cell morphology 183
          abnormal leukocyte morphology 151
            abnormal myeloid leukocyte morphology 67
              abnormal phagocyte morphology 44
                abnormal mononuclear phagocyte morphology 39
                  abnormal myeloid dendritic cell morphology 3
                    abnormal Langerhans cell morphology 3
                      abnormal Langerhans cell number 3
                        decreased Langerhans cell number + 3
                        increased Langerhans cell number 0
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