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MAMMALIAN PHENOTYPE - ANNOTATIONS

The Mouse Adult Gross Anatomy Ontology and Mammalian Phenotype Ontology are downloaded weekly from the Mouse Genome Informatics databases at Jackson Laboratories (ftp://ftp.informatics.jax.org/pub/reports/index.html). For more information about these ontologies, see the MGI Publications Page at http://www.informatics.jax.org/mgihome/other/publications.shtml.
Term:abnormal sebocyte differentiation
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Accession:MP:0013376 term browser browse the term
Definition:abnormal formation or arrest of differentiation of the sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation; these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection; sebocyte differentiation is defined by increasing accumulation of lipid droplets, the major component of sebum
Synonyms:exact_synonym: abnormal acinar cell of sebaceous gland differentiation;   abnormal sebaceous epithelial cell differentiation


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abnormal sebocyte differentiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha IAGP MGI PMID:20352127 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta IAGP MGI PMID:20352127 NCBI chr 2:167,530,835...167,532,352
Ensembl chr 2:167,530,835...167,532,338 		JBrowse link
G Far2 fatty acyl CoA reductase 2 IAGP MGI PMID:30372477 NCBI chr 6:147,948,914...148,084,256
Ensembl chr 6:147,948,757...148,084,256 		JBrowse link
G Krt10 keratin 10 IAGP MGI PMID:15679119 NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  mammalian phenotype 16534
    integument phenotype 2651
      abnormal skin adnexa morphology 1478
        abnormal skin adnexa development 246
          abnormal sebocyte differentiation 4
Path 2
Term Annotations click to browse term
  mammalian phenotype 16534
    endocrine/exocrine gland phenotype 3375
      abnormal gland morphology 3139
        abnormal exocrine gland morphology 1081
          abnormal holocrine gland morphology 114
            abnormal sebaceous gland morphology 114
              abnormal sebocyte morphology 16
                abnormal sebocyte differentiation 4
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